moocRP: Enabling Open Learning Analytics with an Open Source Platform for Data Distribution, Analysis, and Visualization

In this paper, we address issues of transparency, modularity, and privacy with the introduction of an open source, web-based data repository and analysis tool tailored to the Massive Open Online Course community. The tool integrates data request/authorization and distribution workflow features as well as provides a simple analytics module upload format to enable reuse and replication of analytics results among instructors and researchers. We survey the evolving landscape of competing established and emerging data models, all of which are accommodated in the platform. Data model descriptions are provided to analytics authors who choose, much like with smartphone app stores, to write for any number of data models depending on their needs and the proliferation of the particular data model. Two case study examples of analytics and responsive visualizations based on different data models are described in the paper. The result is a simple but effective approach to learning analytics immediately applicable to X consortium MOOCs and beyond

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants remains unclear. Here we describe that rare coding variants in lupus-risk genes are present in most SLE patients and healthy controls. We demonstrate the functional consequences of rare and low frequency missense variants in the interacting proteins BLK and BANK1, which are present alone, or in combination, in a substantial proportion of lupus patients. The rare variants found in patients, but not those found exclusively in controls, impair suppression of IRF5 and type-I IFN in human B cell lines and increase pathogenic lymphocytes in lupus-prone mice. Thus, rare gene variants are common in SLE and likely contribute to genetic risk