Hardware/Software Co-Design of Ultra-Low Power Biomedical Monitors

Ongoing changes in world demographics and the prevalence of unhealthy lifestyles are imposing a paradigm shift in healthcare delivery. Nowadays, chronic ailments such as cardiovascular diseases, hypertension and diabetes, represent the most common causes of death according to the World Health Organization. It is estimated that 63% of deaths worldwide are directly or indirectly related to these non-communicable diseases (NCDs), and by 2030 it is predicted that the health delivery cost will reach an amount comparable to 75% of the current GDP. In this context, technologies based on Wireless Sensor Nodes (WSNs) effectively alleviate this burden enabling the conception of wearable biomedical monitors composed of one or several devices connected through a Wireless Body Sensor Network (WBSN). Energy efficiency is of paramount importance for these devices, which must operate for prolonged periods of time with a single battery charge. In this thesis I propose a set of hardware/software co-design techniques to drastically increase the energy efficiency of bio-medical monitors. To this end, I jointly explore different alternatives to reduce the required computational effort at the software level while optimizing the power consumption of the processing hardware by employing ultra-low power multi-core architectures that exploit DSP application characteristics. First, at the sensor level, I study the utilization of a heartbeat classifier to perform selective advanced DSP on state-of-the-art ECG bio-medical monitors. To this end, I developed a framework to design and train real-time, lightweight heartbeat neuro-fuzzy classifiers, detail- ing the required optimizations to efficiently execute them on a resource-constrained platform. Then, at the network level I propose a more complex transmission-aware WBSN for activity monitoring that provides different tradeoffs between classification accuracy and transmission volume. In this work, I study the combination of a minimal set of WSNs with a smartphone, and propose two classification schemes that trade accuracy for transmission volume. The proposed method can achieve accuracies ranging from 88% to 97% and can save up to 86% of wireless transmissions, outperforming the state-of-the-art alternatives. Second, I propose a synchronization-based low-power multi-core architecture for bio-signal processing. I introduce a hardware/software synchronization mechanism that allows to achieve high energy efficiency while parallelizing the execution of multi-channel DSP applications. Then, I generalize the methodology to support bio-signal processing applications with an arbitrarily high degree of parallelism. Due to the benefits of SIMD execution and software pipelining, the architecture can reduce its power consumption by up 38% when compared to an equivalent low-power single-core alternative. Finally, I focused on the optimization of the multi-core memory subsystem, which is the major contributor to the overall system power consumption. First I considered a hybrid memory subsystem featuring a small reliable partition that can operate at ultra-low voltage enabling low-power buffering of data and obtaining up to 50% energy savings. Second, I explore a two-level memory hierarchy based on non-volatile memories (NVM) that allows for aggressive fine-grained power gating enabled by emerging low-power NVM technologies and monolithic 3D integration. Experimental results show that, by adopting this memory hierarchy, power consumption can be reduced by 5.42x in the DSP stage

An Ultra-Low Power NVM-Based Multi-Core Architecture for Embedded Bio Signal Processing

Healthcare delivery is evolving towards new Wireless Body Sensor Nodes (WBSN), which are miniaturized devices able to acquire, process and transmit subjects’ bio-signals in real time within a tiny energy budget. Recent efforts on AD converters and transmission schemes have enabled a major power consumption reduction of these components, thus leaving the embedded processing stage as the dominant power-hungry component. In this context, new multi-core architectures designed with smaller CMOS devices and aggressive voltage scaling greatly improve the energy efficiency of WBSNs, but originate reliability operation concerns. In this work we present a novel WBSN architecture equipped with a completely redesigned memory subsystem (including a low-voltage low-latency non-volatile partition), which operates in combination with an advanced code synchronization management to reduce the platform ower consumption by up to 82%

A Methodology for Embedded Classification of Heartbeats Using Random Projections

Smart Wireless Body Sensor Nodes (WBSNs) are a novel class of unobtrusive, battery-powered devices allowing the continuous monitoring and real-time interpretation of a subject’s bio-signals. One of its most relevant applications is the acquisition and analysis of Electrocardiograms (ECGs). These low-power WBSN designs, while able to perform advanced signal processing to extract information on hearth conditions of subjects, are usually constrained in terms of computational power and transmission bandwidth. It is therefore beneficial to identify in the early stages of analysis which parts of an ECG acquisition are critical and activate only in these cases detailed (and computationally intensive) diagnosis algorithms. In this paper, we introduce and study the performance of a real-time optimized neuro-fuzzy classifier based on random projections, which is able to discern normal and pathological heartbeats on an embedded WBSN. Moreover, it exposes high confidence and low computational and memory requirements. Indeed, by focusing on abnormal heartbeats morphologies, we proved that a WBSN system can effectively enhance its efficiency, obtaining energy savings of as much as 63% in the signal processing stage and 68% in the subsequent wireless transmission when the proposed classifier is employed

Hardware/Software Approach for Code Synchronization in Low-Power Multi-Core Sensor Nodes

Latest embedded bio-signal analysis applications, targeting low-power Wireless Body Sensor Nodes (WBSNs), present conflicting requirements. On one hand, bio-signal analysis applications are continuously increasing their demand for high computing capabilities. On the other hand, long-term signal processing in WBSNs must be provided within their highly constrained energy budget. In this context, parallel processing effectively increases the power efficiency of WBSNs, but only if the execution can be properly synchronized among computing elements. To address this challenge, in this work we propose a hardware/software approach to synchronize the execution of bio-signal processing applications in multi-core WBSNs. This new approach requires little hardware resources and very few adaptations in the source code. Moreover, it provides the necessary flexibility to execute applications with an arbitrarily large degree of complexity and parallelism, enabling considerable reductions in power consumption for all multi-core WBSN execution conditions. Experimental results show that a multi-core WBSN architecture using the illustrated approach can obtain energy savings of up to 40%, with respect to an equivalent singlecore architecture, when performing advanced bio-signal analysi

Embedded Real-Time ECG Delineation Methods: a Comparative Evaluation

Wireless sensor nodes (WSNs) have recently evolved to include a fair amount of computational power, so that advanced signal processing algorithms can now be embedded even in this extremely low-power platforms. An increasingly successful field of application of WSNs is tele-healthcare, which enables continous monitoring of subjects, even outside a medical environment. In particular, the design of solutions for automated and remote electrocardiogram (ECG) analysis have attracted considerable research interest in recent years, and different algorithms for delineation of normal and pathological heart rhythms have been proposed. In this paper, some of the most promising techniques for filtering and delinations of ECG signals are explored and comparatively evaluated, describing their implementation on the state-of-the-art IcyHeart WSN. The goal of this paper is to explore the trade-offs implied in the different settings and the impact of design choices for implementing “smart” WSNs dedicated to monitoring ECG bio-signal

A Synchronization-Based Hybrid-Memory Multi-Core Architecture for Energy-Efficient Biomedical Signal Processing

In the last decade, improvements on technology scaling have enabled the design of a novel generation of wearable bio-sensing monitors. These smart Wireless Body Sensor Nodes (WBSNs) are able to acquire and process biological signals, such as electrocardiograms, for periods of time extending from hours to days. The energy required for the on-node digital signal processing (DSP) is a crucial limiting factor in the conception of these devices. To address this design challenge, we introduce a domain-specific ultra-low power (ULP) architecture dedicated to bio-signal processing. The platform features a light-weight strategy to support different operating modes and synchronization among cores. Our approach effectively reduces the power consumption, harnessing the intrinsic parallelism and the workload requirements characterizing the target domain. Operations at low voltage levels are supported by a heterogeneous memory subsystem comprising a standard-cell based ultra-low voltage reliable partition. Experimental results show that, when executing real-world bio-signal DSP applications, a state-of-the-art multi-core architecture can improve its energy efficiency in up to 50% by utilizing our proposed approach, outperforming traditional single-core alternatives

A Wireless Body Sensor Network For Activity Monitoring With Low Transmission Overhead

Activity recognition has been a research field of high interest over the last years, and it finds application in the medical domain, as well as personal healthcare monitoring during daily home- and sports-activities. With the aim of producing minimum discomfort while performing supervision of subjects, miniaturized networks of low-power wireless nodes are typically deployed on the body to gather and transmit physiological data, thus forming a Wireless Body Sensor Network (WBSN). In this work, we propose a WBSN for online activity monitoring, which combines the sensing capabilities of wearable nodes and the high computational resources of modern smartphones. The proposed solution provides different tradeoffs between classification accuracy and energy consumption, thanks to different workloads assigned to the nodes and to the mobile phone in different network configurations. In particular, our WBSN is able to achieve very high activity recognition accuracies (up to 97.2%) on multiple subjects, while significantly reducing the sampling frequency and the volume of transmitted data with respect to other state-of-the art solutions

HEAL-WEAR: an Ultra-Low Power Heterogeneous System for Bio-Signal Analysis

Personalized healthcare devices enable low-cost, unobtrusive and long-term acquisition of clinically-relevant biosignals. These appliances, termed Wireless Body Sensor Nodes (WBSNs), are fostering a revolution in health monitoring for patients affected by chronic ailments. Nowadays, WBSNs often embed complex digital processing routines, which must be performed within an extremely tight energy budget. Addressing this challenge, in this paper we introduce a novel computing architecture devoted to the ultra-low power analysis of biosignals. Its heterogeneous structure comprises multiple processors interfaced with a shared acceleration resource, implemented as a Coarse Grained Reconfigurable Array (CGRA). The CGRA mesh effectively supports the execution of the intensive loops that characterize bio-signal analysis applications, while requiring a low reconfiguration overhead. Moreover, both the processors and the reconfigurable fabric feature Single-Instruction / Multiple- Data (SIMD) execution modes, which increase efficiency when multiple data streams are concurrently processed. The run-time behavior on the system is orchestrated by a light-weight hardware mechanism, which concurrently synchronizes processors for SIMD execution and regulates access to the reconfigurable accelerator. By jointly leveraging run-time reconfiguration and SIMD execution, the illustrated heterogeneous system achieves, when executing complex bio-signal analysis applications, speedups of up to 11.3x on the considered kernels and up to 37.2% overall energy savings, with respect to an ultra-low power multicore platform which does not feature CGRA acceleration

A Multi-Core Reconfigurable Architecture for Ultra-Low Power Bio-Signal Analysis

This paper introduces a novel computing architecture devoted to the ultra-low power analysis of multiple bio-signals. Its structure comprises several processors interfaced with a shared acceleration resource, implemented as a Coarse Grained Reconfigurable Array (CGRA). The CGRA supports the efficient execution of the computationally intensive kernels present in this application domain, while requiring a low reconfiguration overhead. The run-time behavior of the resulting heterogeneous system is orchestrated by a light-weight hardware mechanism, which concurrently synchronizes processors and regulates access to the reconfigurable accelerator. The architecture achieves speed-ups of up to 11x on different bio-signal processing kernels and system-level energy savings of up to 18.6%, with respect to a multi-core platform, which does not feature CGRA acceleration

An Inexact Ultra-low Power Bio-signal Processing Architecture With Lightweight Error Recovery

The energy efficiency of digital architectures is tightly linked to the voltage level (Vdd) at which they operate. Aggressive voltage scaling is therefore mandatory when ultra-low power processing is required. Nonetheless, the lowest admissible Vdd is oen bounded by reliability concerns, especially since static and dynamic non-idealities are exacerbated in the near-threshold region, imposing costly guard-bands to guarantee correctness under worst-case conditions. A striking alternative, explored in this paper, waives the requirement for unconditional correctness, undergoing more relaxed constraints. First, aer a run-time failure, processing correctly resumes at a later point in time. Second, failures induce a limited Quality-of-Service (QoS) degradation. We focus our investigation on the practical scenario of embedded bio-signal analysis, a domain in which energy efficiency is key, while applications are inherently error-tolerant to a certain degree. Targeting a domain-specific multi-core platform, we present a study of the impact of inexactness on application-visible errors. en, we introduce a novel methodology to manage them, which requires minimal hardware resources and a negligible energy overhead. Experimental evidence show that, by tolerating 900 errors/hour, the resulting inexact platform can achieve an efficiency increase of up to 24%, with a QoS degradation of less than 3%