Evolutionary history of the Nesophontidae, the last unplaced Recent mammal family

The mammalian evolutionary tree has lost several major clades through recent human-caused extinctions. This process of historical biodiversity loss has particularly affected tropical island regions such as the Caribbean, an area of great evolutionary diversification but poor molecular preservation. The most enigmatic of the recently extinct endemic Caribbean mammals are the Nesophontidae, a family of morphologically plesiomorphic lipotyphlan insectivores with no consensus on their evolutionary affinities, and which constitute the only major recent mammal clade to lack any molecular information on their phylogenetic placement. Here, we use a palaeogenomic approach to place Nesophontidae within the phylogeny of recent Lipotyphla. We recovered the near-complete mitochondrial genome and sequences for 17 nuclear genes from a ∼750-year-old Hispaniolan Nesophontes specimen, and identify a divergence from their closest living relatives, the Solenodontidae, more than 40 million years ago. Nesophontidae is thus an older distinct lineage than many extant mammalian orders, highlighting not only the role of island systems as “museums” of diversity that preserve ancient lineages, but also the major human-caused loss of evolutionary history

Performance characteristics of five triage tools for major incidents involving traumatic injuries to children

Context Triage tools are an essential component of the emergency response to a major incident. Although fortunately rare, mass casualty incidents involving children are possible which mandate reliable triage tools to determine the priority of treatment. Objective To determine the performance characteristics of five major incident triage tools amongst paediatric casualties who have sustained traumatic injuries. Design, setting, participants Retrospective observational cohort study using data from 31,292 patients aged less than 16 years who sustained a traumatic injury. Data were obtained from the UK Trauma Audit and Research Network (TARN) database. Interventions Statistical evaluation of five triage tools (JumpSTART, START, CareFlight, Paediatric Triage Tape/Sieve and Triage Sort) to predict death or severe traumatic injury (injury severity score >15). Main outcome measures Performance characteristics of triage tools (sensitivity, specificity and level of agreement between triage tools) to identify patients at high risk of death or severe injury. Results Of the 31,292 cases, 1029 died (3.3%), 6842 (21.9%) had major trauma (defined by an injury severity score >15) and 14,711 (47%) were aged 8 years or younger. There was variation in the performance accuracy of the tools to predict major trauma or death (sensitivities ranging between 36.4 and 96.2%; specificities 66.0–89.8%). Performance characteristics varied with the age of the child. CareFlight had the best overall performance at predicting death, with the following sensitivity and specificity (95% CI) respectively: 95.3% (93.8–96.8) and 80.4% (80.0–80.9). JumpSTART was superior for the triaging of children under 8 years; sensitivity and specificity (95% CI) respectively: 86.3% (83.1–89.5) and 84.8% (84.2–85.5). The triage tools were generally better at identifying patients who would die than those with non-fatal severe injury. Conclusion This statistical evaluation has demonstrated variability in the accuracy of triage tools at predicting outcomes for children who sustain traumatic injuries. No single tool performed consistently well across all evaluated scenarios

Establishing the values for patient engagement (PE) in health-related quality of life (HRQoL) research: an international, multiple-stakeholder perspective

PurposeActive patient engagement is increasingly viewed as essential to ensuring that patient-driven perspectives are considered throughout the research process. However, guidance for patient engagement (PE) in HRQoL research does not exist, the evidence-base for practice is limited, and we know relatively little about underpinning values that can impact on PE practice. This is the first study to explore the values that should underpin PE in contemporary HRQoL research to help inform future good practice guidance. MethodsA modified ‘World Café’ was hosted as a collaborative activity between patient partners, clinicians and researchers: self-nominated conference delegates participated in group discussions to explore values associated with the conduct and consequences of PE. Values were captured via post-it notes and by nominated note-takers. Data were thematically analysed: emergent themes were coded and agreement checked. Association between emergent themes, values and the Public Involvement Impact Assessment Framework were explored. ResultsEighty participants, including 12 patient partners, participated in the 90-min event. Three core values were defined: (1) building relationships; (2) improving research quality and impact; and (3) developing best practice. Participants valued the importance of building genuine, collaborative and deliberative relationships—underpinned by honesty, respect, co-learning and equity—and the impact of effective PE on research quality and relevance. Conclusions An explicit statement of values seeks to align all stakeholders on the purpose, practice and credibility of PE activities. An innovative, flexible and transparent research environment was valued as essential to developing a trustworthy evidence-base with which to underpin future guidance for good PE practice.Peer reviewe

Tachyon Condensation on Noncommutative Torus

We discuss noncommutative solitons on a noncommutative torus and their application to tachyon condensation. In the large B limit, they can be exactly described by the Powers-Rieffel projection operators known in the mathematical literature. The resulting soliton spectrum is consistent with T-duality and is surprisingly interesting. It is shown that an instability arises for any D-branes, leading to the decay into many smaller D-branes. This phenomenon is the consequence of the fact that K-homology for type II von Neumann factor is labeled by R.Comment: LaTeX, 17 pages, 1 figur

Energy-momentum and angular momentum of Goedel universes

We discuss the Einstein energy-momentum complex and the Bergmann-Thomson angular momentum complex in general relativity and calculate them for space-time homogeneous Goedel universes. The calculations are performed for a dust acausal model and for a scalar-field causal model. It is shown that the Einstein pseudotensor is traceless, not symmetric, the gravitational energy is "density" is negative and the gravitational Poynting vector vanishes. Significantly, the total (gravitational and matter) energy "density" fro the acausal model is zero while for the casual model it is negative.The Bergmann-Thomson angular momentum complex does not vanish for both G\"odel models.Comment: an amended version, 24 pages, accepted to PR

Superfield T-duality rules

A geometric treatment of T-duality as an operation which acts on differential forms in superspace allows us to derive the complete set of T-duality transformation rules which relate the superfield potentials of D=10 type IIA supergravity with those of type IIB supergravity including Ramond-Ramond superfield potentials and fermionic supervielbeins. We show that these rules are consistent with the superspace supergravity constraints.Comment: 24 pages, latex, no figures. V2 misprints corrected. V3. One reference ([30]) and a comment on it ('Notice added') on p. 19 adde

Human disease/clinical medical sciences for dentistry in early-years dental graduates: Transition from undergraduate study to clinical practice

Introduction Dental bodies across Europe have published curricula aiming to guide the development of a graduating dentist who is safe and competent, and which also contain direction on what knowledge and understanding of patient's health, drugs and disease a recent graduate should have. Materials, Methods and Aim A questionnaire to survey Foundation Dentists in Wales regarding their undergraduate teaching and assessment in human disease/clinical medical science for dentistry and how this translates to their knowledge, attitudes and confidence in the dental management of patients who may have chronic disease or disability. Results A 97% response rate to the questionnaire from Foundation Dentists graduating from schools across the UK showed that the large majority felt their teaching and learning in human disease/clinical medical science for dentistry was appropriately delivered and assessed, and that they were well prepared for independent dental practice and to plan and safely manage treatments for all their patients. Discussion This survey of newly qualified dentists representing graduates from different types of dental courses and both newer and long‐established schools across the UK reports the foundation dentists felt that they are competent and safe to care for all patients, including those with complex medical histories. Conclusions The foundation dentists surveyed have completed dental undergraduate courses containing the appropriate education and assessment for human health and disease, such that they are prepared to manage their patient population safely, and are well placed to serve their patients as the population continues to age and the amount of medical morbidity increases

Dynamics and stability of the Godel universe

We use covariant techniques to describe the properties of the Godel universe and then consider its linear response to a variety of perturbations. Against matter aggregations, we find that the stability of the Godel model depends primarily upon the presence of gradients in the centrifugal energy, and secondarily on the equation of state of the fluid. The latter dictates the behaviour of the model when dealing with homogeneous perturbations. The vorticity of the perturbed Godel model is found to evolve as in almost-FRW spacetimes, with some additional directional effects due to shape distortions. We also consider gravitational-wave perturbations by investigating the evolution of the magnetic Weyl component. This tensor obeys a simple plane-wave equation, which argues for the neutral stability of the Godel model against linear gravity-wave distortions. The implications of the background rotation for scalar-field Godel cosmologies are also discussed.Comment: Revised version, to match paper published in Class. Quantum Gra

The lady vanishes: what's missing from the stem cell debate

Most opponents of somatic cell nuclear transfer and embryonic stem cell technologies base their arguments on the twin assertions that the embryo is either a human being or a potential human being, and that it is wrong to destroy a human being or potential human being in order to produce stem cell lines. Proponents’ justifications of stem cell research are more varied, but not enough to escape the charge of obsession with the status of the embryo. What unites the two warring sides in ‘the stem cell wars’ is that women are equally invisible to both: ‘the lady vanishes’. Yet the only legitimate property in the body is that which women possess in their reproductive tissue and the products of their reproductive labour. By drawing on the accepted characterisation in law of property as a bundle of rights, and on a Hegelian model of contract as mutual recognition, we can lessen the impact of the tendency to regard women and their eggs as merely receptacles and women’s reproductive labour as unimportant