Application of Fuzzy Algorithms for Controlling the Modes of Solar Panels in Technological Monitoring at Peak Load

The functional structure of geoecological and technological monitoring systems is analyzed. It is shown that the complication of the multifunctional automated system of geoecological and technological monitoring (MF AS) and the increase in its dynamics aggravates uncertainty of its condition estimation. An uncertainty model of the state of a multifunctional automated system of geoecological and technological monitoring has been developed. To implement the model, fuzzy sets of linguistic estimates fluctuating in time are obtained. The application of fuzzy algorithms to control the modes of solar panels and the detection of failures in thermoelectric systems has been carried out. As a result of the simulation, an increase in the efficiency of the thermoelectric system was revealed by reducing peak loads by 28% and, accordingly, reducing the probability of failures by almost 2 times

Collagen analysis by second-harmonic generation microscopy predicts outcome of luminal breast cancer

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOSecond-harmonic generation microscopy represents an important tool to evaluate extracellular matrix collagen structure, which undergoes changes during cancer progression. Thus, it is potentially relevant to assess breast cancer development. We propose the use of second-harmonic generation images of tumor stroma selected on hematoxylin and eosin–stained slides to evaluate the prognostic value of collagen fibers analyses in peri and intratumoral areas in patients diagnosed with invasive ductal breast carcinoma. Quantitative analyses of collagen parameters were performed using ImageJ software. These parameters presented significantly higher values in peri than in intratumoral areas. Higher intratumoral collagen uniformity was associated with high pathological stages and with the presence of axillary lymph node metastasis. In patients with immunohistochemistry-based luminal subtype, higher intratumoral collagen uniformity and quantity were independently associated with poorer relapse-free and overall survival, respectively. A multivariate response recursive partitioning model determined 12.857 and 11.894 as the best cut-offs for intratumoral collagen quantity and uniformity, respectively. These values have shown high sensitivity and specificity to differentiate distinct outcomes. Values of intratumoral collagen quantity and uniformity exceeding the cut-offs were strongly associated with poorer relapse-free and overall survival. Our findings support a promising prognostic value of quantitative evaluation of intratumoral collagen by second-harmonic generation imaging mainly in the luminal subtype breast cancer.404118CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO573913/2008-008/57906-