75 research outputs found
The Complex and Important Cellular and Metabolic Functions of Saturated Fatty Acids
This review summarizes recent findings on the metabolism and biological functions of saturated fatty acids (SFA). Some of these findings show that SFA may have important and specific roles in the cells. Elucidated biochemical mechanisms like protein acylation (N-myristoylation, S-palmitoylation) and regulation of gene transcription are presented. In terms of physiology, SFA are involved for instance in lipogenesis, fat deposition, polyunsaturated fatty acids bioavailability and apoptosis. The variety of their functions demonstrates that SFA should no longer be considered as a single group
Composição de ácidos graxos dos cortes comerciais de capivara (Hydrochaeris hydrochaeris L. 1766)
Determinants of early-onset cardiovascular disease: a case-control study of young myocardial infarction patients
Why Is Smoking a Major Risk Factor for Coronary Heart Disease in Hyperlipidemic Subjects?
premature arterial and venous events in three families.Effect of folate levels and MTHFR mutation mediated by family/generation levels
Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients.
Association between multiple cardiovascular risk factors and endothelium dysfunction with myocardial infarction before 40 years of age
Folic acid and Vitamin E supplementation effects on homocysteinernia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients
We examined the effects of folate (either alone or co-supplemented with Vitamin E) on endothelial function in hyperhomocysteinimic patients and correlated results with serum antioxidant capacity. A randomized trial was carried out in 30 young patients with recent acute myocardial infarction (AMI) and high plasma homocysteine concentrations. Intervention consisted of high doses of folate, either alone (group A) or in combination with Vitamin E (group B), for three months. Main outcome measures were endothelial function, serum antioxidant capacity, and homocysteinemia. Folic acid treatment reduced plasma homocysteine concentrations in both groups by 41% and, as compared with baseline values, was associated with a significant (P < 0.001) improvement of endothelial function (from 0.322 (0.03) to 0.450 (0.02) mm in group A and from 0.338 (0.03) to 0.584 (0.04) turn in group 13). However, there was no difference in endothelial function improvement between folic acid and folic acid plus Vitamin E group. Plasma antioxidant capacity significantly (P < 0.001) increased in both groups. In conclusion, beneficial effects of folic acid on vasomotion appear to be independent of antioxidant action but, rather, seem to be strongly associated with reduction of homocysteinemia. Confirming previous reports, the effects of Vitamin E are still equivocal. (C) 2003 Elsevier Ltd. All rights reserved
Premature arterial and venous events in three families. Effects of folate levels and MTHFR mutation mediated by family/generation and homocysteine levels.
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