48 research outputs found
Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies
The closing of the last century opened a wide variety of approaches for inflammation imaging and treatment of patients with rheumatoid arthritis (RA). The introduction of biological therapies for the management of RA started a revolution in the therapeutic armamentarium with the development of several novel monoclonal antibodies (mAbs), which can be murine, chimeric, humanised and fully human antibodies. Monoclonal antibodies specifically bind to their target, which could be adhesion molecules, activation markers, antigens or receptors, to interfere with specific inflammation pathways at the molecular level, leading to immune-modulation of the underlying pathogenic process. These new generation of mAbs can also be radiolabelled by using direct or indirect method, with a variety of nuclides, depending upon the specific diagnostic application. For studying rheumatoid arthritis patients, several monoclonal antibodies and their fragments, including anti-TNF-α, anti-CD20, anti-CD3, anti-CD4 and anti-E-selectin antibody, have been radiolabelled mainly with 99mTc or 111In. Scintigraphy with these radiolabelled antibodies may offer an exciting possibility for the study of RA patients and holds two types of information: (1) it allows better staging of the disease and diagnosis of the state of activity by early detection of inflamed joints that might be difficult to assess; (2) it might provide a possibility to perform ‘evidence-based biological therapy’ of arthritis with a view to assessing whether an antibody will localise in an inflamed joint before using the same unlabelled antibody therapeutically. This might prove particularly important for the selection of patients to be treated since biological therapies can be associated with severe side-effects and are considerably expensive. This article reviews the use of radiolabelled mAbs in the study of RA with particular emphasis on the use of different radiolabelled monoclonal antibodies for therapy decision-making and follow-up
The genome sequence of the commercially cultivated mushroom Agrocybe aegerita reveals a conserved repertoire of fruiting-related genes and a versatile suite of biopolymer-degrading enzymes
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Agreeing to arm: Bilateral weapons agreements and the global arms trade
This article assesses the impact of a new form of defense cooperation – formal weapons cooperation agreements, or WCAs – on the global arms trade. WCAs are bilateral framework agreements that establish comprehensive guidelines on the development, production, and exchange of conventional arms. Substantively, WCAs regulate such core areas as procurement and contracting, defense-based research and development, and defense industrial cooperation. These agreements have proliferated dramatically since the mid-1990s. They now number nearly 700, with 30–40 new WCAs signed each year. Newly collected data are used to analyze the effect of WCAs on import and export of conventional weapons. To control for interdependencies in the formation of WCAs, and to account for the mutually endogenous relationship between WCAs and weapons flows, WCAs are modeled as an interdependent network that coevolves with the individual-level arms trade activity of states. The analysis shows that, over the 1995–2010 period, WCAs have significantly increased weapons flows
Agreeing to arm: Bilateral weapons agreements and the global arms trade
This article assesses the impact of a new form of defense cooperation – formal weapons cooperation agreements, or WCAs – on the global arms trade. WCAs are bilateral framework agreements that establish comprehensive guidelines on the development, production, and exchange of conventional arms. Substantively, WCAs regulate such core areas as procurement and contracting, defense-based research and development, and defense industrial cooperation. These agreements have proliferated dramatically since the mid-1990s. They now number nearly 700, with 30–40 new WCAs signed each year. Newly collected data are used to analyze the effect of WCAs on import and export of conventional weapons. To control for interdependencies in the formation of WCAs, and to account for the mutually endogenous relationship between WCAs and weapons flows, WCAs are modeled as an interdependent network that coevolves with the individual-level arms trade activity of states. The analysis shows that, over the 1995–2010 period, WCAs have significantly increased weapons flows
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Defense Cooperation Agreements and the Emergence of a Global Security Network
Bilateral defense cooperation agreements, or DCAs, are now the most common form of institutionalized defense cooperation. These formal agreements establish broad defense-oriented legal frameworks between signatories, facilitating cooperation in such fundamental areas as defense policy coordination, research and development, joint military exercises, education and training, arms procurement, and exchange of classified information. Although nearly a thousand DCAs are currently in force, with potentially wide-ranging impacts on national and international security outcomes, DCAs have been largely ignored by scholars. Why have DCAs proliferated? I develop a theory that integrates cooperation theory with insights from social network analysis. Shifts in the global security environment since the 1980s have fueled demand for DCAs. States use DCAs to modernize their militaries, respond to shared security threats, and establish security umbrellas with like-minded states. Yet, demand alone cannot explain DCA proliferation; to cooperate, governments must also overcome dilemmas of mistrust and distributional conflicts. I show that network influences increase the supply of DCAs by providing governments with information about the trustworthiness of partners and the risk of asymmetric distributions of gains. DCAs become easier to sign as more states sign them. I identify two specific network influences - preferential attachment and triadic closure - and show that these influences are largely responsible for the post-Cold War diffusion of DCAs. Novel empirical strategies further indicate that these influences derive from the proposed informational mechanism. States use the DCA ties of others to glean information about prospective defense partners, thus endogenously fueling further growth of the global DCA network
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The Defense Cooperation Agreement Dataset (DCAD)
The academic study of defense cooperation focuses heavily on formal military alliances. Yet, governments rarely sign new alliances, and the global alliance structure has remained relatively static for decades. By contrast, governments are increasingly active in defense cooperation agreements (DCAs). These bilateral framework treaties institutionalize their signatories’ day-to-day defense relations, facilitating such wide-ranging activities as defense policy coordination, joint research and development, weapons production and arms trade, joint military exercises, training and exchange programs, peacekeeping, and information exchange. Nearly 2,000 DCAs have been signed since 1980. Preliminary evidence suggests that DCAs impact numerous security, military, and defense outcomes and that governments increasingly incorporate DCAs as core elements of their security strategies. This article introduces the new DCA Dataset (DCAD). I provide a brief historical background on DCAs and compare them to other commonly studied forms of defense cooperation. I then explain coding standards and describe the data set in detail. Finally, I illustrate applications of DCAD to militarized interstate disputes and arms trade
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Guns or Money? Defense Co-operation and bilateral lending as coevolving networks
How are defense co-operation and economic co-operation related? To answer this question, this article analyzes the coevolution of defense co-operation agreements (DCAs) and government-to-government loans. It argues that governments pursue two distinct sets of interests. At the bilateral level, governments use issue linkages and side payments to encourage spillover from defense co-operation to economic co-operation, and vice versa. That is, governments' bilateral interests in DCAs and loans are largely complementary. However, at the network level, interests may diverge. Specifically, governments use DCAs to build clubs of like-minded defense collaborators or 'security communities', while they use loans to impose asymmetric forms of political authority or 'hierarchies'. In some contexts, these network-level interests are, like bilateral interests, complementary. For example, defense partners rely on loans to co-ordinate their foreign policies and better respond to security threats, and debtors rely on lending patterns to identify suitable defense partners. In other cases, however, these interests strongly conflict. For example, governments that are highly active in the loan network are especially likely to rely on asymmetric exercises of political authority, which is incompatible with the network-level goal of using DCAs to establish communities of defense collaborators. Similarly, governments that are highly active in the DCA network are, due to their complex multilateral political commitments, less vulnerable to the asymmetric influences that loans enable. To empirically test these claims, the study develops a longitudinal model of multiplex network coevolution. Overall, the results show that while economic and defense co-operation often reinforce one another, they sometimes conflict in unexpected ways