25 research outputs found
Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin.
Published versio
Host Iron Binding Proteins Acting as Niche Indicators for Neisseria meningitidis
Neisseria meningitidis requires iron, and in the absence of iron alters its gene expression to increase iron acquisition and to make the best use of the iron it has. During different stages of colonization and infection available iron sources differ, particularly the host iron-binding proteins haemoglobin, transferrin, and lactoferrin. This study compared the transcriptional responses of N. meningitidis, when grown in the presence of these iron donors and ferric iron, using microarrays
Gravitational Wave Detection by Interferometry (Ground and Space)
Significant progress has been made in recent years on the development of
gravitational wave detectors. Sources such as coalescing compact binary
systems, neutron stars in low-mass X-ray binaries, stellar collapses and
pulsars are all possible candidates for detection. The most promising design of
gravitational wave detector uses test masses a long distance apart and freely
suspended as pendulums on Earth or in drag-free craft in space. The main theme
of this review is a discussion of the mechanical and optical principles used in
the various long baseline systems in operation around the world - LIGO (USA),
Virgo (Italy/France), TAMA300 and LCGT (Japan), and GEO600 (Germany/U.K.) - and
in LISA, a proposed space-borne interferometer. A review of recent science runs
from the current generation of ground-based detectors will be discussed, in
addition to highlighting the astrophysical results gained thus far. Looking to
the future, the major upgrades to LIGO (Advanced LIGO), Virgo (Advanced Virgo),
LCGT and GEO600 (GEO-HF) will be completed over the coming years, which will
create a network of detectors with significantly improved sensitivity required
to detect gravitational waves. Beyond this, the concept and design of possible
future "third generation" gravitational wave detectors, such as the Einstein
Telescope (ET), will be discussed.Comment: Published in Living Reviews in Relativit
Lawson criterion for ignition exceeded in an inertial fusion experiment
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion