7 research outputs found

    Micro-scale flood risk analysis based on detailed 2D hydraulic modelling and high resolution geographic data

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    peer reviewedThe paper presents a consistent micro-scale flood risk analysis procedure, relying on detailed 2D inundation modelling as well as on high resolution topographic and land use database. The flow model is based on the shallow-water equations, solved by means of a finite volume scheme on multiblock structured grids. Using highly accurate laser altimetry, the simulations are performed with a typical grid spacing of 2m, which is fine enough to represent the flow at the scale of individual buildings. Consequently, the outcomes of hydraulic modelling constitute suitable inputs for the subsequent exposure analysis, performed at a micro-scale using detailed land use maps and geographic database. Eventually, the procedure incorporates social flood impact analysis and evaluation of direct economic damage to residential buildings. Besides detailing the characteristics and performance of the hydraulic model, the paper describes the flow of data within the overall flood risk analysis procedure and demonstrates its applicability by means of a case study, for which two different flood protection measures were evaluated

    Experimental and numerical analysis of flow instabilities in rectangular shallow basins

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    Free surface flows in several shallow rectangular basins have been analyzed experimentally, numerically and theoretically. Different geometries, characterized by different widths and lengths, are considered as well as different hydraulic conditions. First, the results of a series of experimental tests are briefly depicted. They reveal that, under clearly identified hydraulic and geometrical conditions, the flow pattern is found to become nonsymmetric, in spite of the symmetrical inflow conditions, outflow conditions and geometry of the basin. This non-symmetric motion results from the growth of small disturbances actually present in the experimental initial and boundary conditions. Second, numerical simulations are conducted based on a depth-averaged approach and a finite volume scheme. The simulation results reproduce the global pattern of the flow observed experimentally and succeed in predicting the stability or instability of a symmetric flow pattern for all tested configurations. Finally, an analytical study provides mathematical insights into the conditions under which the symmetric flow pattern becomes unstable and clarifies the governing physical processes

    River modelling and flood mitigation in a Belgian catchment

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    This paper describes the steps followed to propose solutions to recurring flooding problems in a Belgian catchment. Firstly, the hydraulic capacity (maximum discharge before bank overflow) of the cross sections was computed all along the river by an iterative 1D steady-state approach. In order to carry out these simulations, cross sections from on-site surveys of the river were integrated into the model, as well as hydraulic structures such as culverts, footbridges, and pipes. Secondly, the flooding problem was analysed with a time-dependant approach consisting of simulating floods following extreme rainfall events. The hydrological aspect was studied in a spatially distributed way using a multi-layer hydrological model. The available data on the basin such as the digital elevation model (DEM), the landuse, and the pedology were exploited to identify the basic modelling parameters. The hydrological contribution was routed by a 1D network resulting from the merging of the DEM-based and the cross section-based river networks. According to the results of the aforementioned steps, various local and catchment-wide solutions against flooding were proposed and analyzed. The comparison of simulated situations before and after these improvements allowed checking the effectiveness of the proposed solutions

    Predictive applications of Australian flood loss models after a temporal and spatial transfer

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    In recent decades, considerably greater flood losses have increased attention to flood risk evaluation. This study used data-sets collected from Queensland flood events and investigated the predictive capacity of three new Australian flood loss models to assess the extent of physical damages, after a temporal and spatial transfer. The models’ predictive power is tested for precision, variation, and reliability. The performance of a new Australian flood loss function was contrasted with two tree-based damage models, one pruned and one un-pruned. The tree-based models are grown based on the interaction of flood loss ratio with 13 examined predictors gathered from flood specifications, building characteristics, and mitigation actions. Besides an overall comparison, the prediction capacity is also checked for some sub-classes of water depth and some groups of building-type. It has been shown that considering more details of the flood damage process can improve the predictive capacity of damage prediction models. In this regard, complexity with parameters with low predictive power may lead to more uncertain results. On the other hand, it has also been demonstrated that the probability analysis approach can make damage models more reliable when they are subjected to use in different flooding events

    IL-4Ralpha-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.

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    In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Ralpha and IL-13; but not IL-4. Protection did not associate with parasite specific antibody responses. Re-infection of B cell-specific IL-4Ralpha(-)/(-) mice resulted in increased worm burdens compared to control mice, despite their equivalent capacity to control primary infection. Impaired protection correlated with reduced lymphocyte IL-13 production and B cell MHC class II and CD86 surface expression. Adoptive transfer of in vivo N. brasiliensis primed IL-4Ralpha expressing B cells into naive BALB/c mice, but not IL-4Ralpha or IL-13 deficient B cells, conferred protection against primary N. brasiliensis infection. This protection required MHC class II compatibility on B cells suggesting cognate interactions by B cells with CD4(+) T cells were important to co-ordinate immunity. Furthermore, the rapid nature of these protective effects by B cells suggested non-BCR mediated mechanisms, such as via Toll Like Receptors, was involved, and this was supported by transfer experiments using antigen pulsed Myd88(-)/(-) B cells. These data suggest TLR dependent antigen processing by IL-4Ralpha-responsive B cells producing IL-13 contribute significantly to CD4(+) T cell-mediated protective immunity against N. brasiliensis infection

    IL-4Ralpha-responsive smooth muscle cells contribute to initiation of T(H)2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections.

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    Nippostrongylus brasiliensis infections generate pulmonary pathologies that can be associated with strong T(H)2 polarization of the host's immune response. We present data demonstrating N. brasiliensis-driven airway mucus production to be dependent on smooth muscle cell interleukin 4 receptor-alpha (IL-4Ralpha) responsiveness. At days 7 and 10 post infection (PI), significant airway mucus production was found in IL-4Ralpha(-/lox) control mice, whereas global knockout (IL-4Ralpha(-/-)) and smooth muscle-specific IL-4Ralpha-deficient mice (SM-MHC(Cre) IL-4Ralpha(-/lox)) showed reduced airway mucus responses. Furthermore, interleukin (IL)-13 and IL-5 cytokine production in SM-MHC(Cre) IL-4Ralpha(-/lox) mice was impaired along with a transient reduction in T-cell numbers in the lung. In vitro treatment of smooth muscle cells with secreted N. brasiliensis excretory-secretory antigen (NES) induced IL-6 production. Decreased protein kinase C (PKC)-dependent smooth muscle cell proliferation associated with cell cycle arrest was found in cells stimulated with NES. Together, these data demonstrate that both IL-4Ralpha and NES-driven responses by smooth muscle cells make important contributions in initiating T(H)2 responses against N. brasiliensis infections.Mucosal Immunology advance online publication 25 August 2010. doi:10.1038/mi.2010.46
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