Vitamin E supplementation and renal functions in acute celphos poisoning

Background: The present study was designed to evaluate the effects of vitamin E on phostoxin-induced changes in renal biochemical parameters in rats. Methods: Thirty disease free albino rats were selected to study the effect of acute aluminum phosphide poisoning (ALP poisoning) were further divided into 3 subgroups of ten each: A, B and C. Group A consists of rats given vehicle (Ginni Oil) only. Group B consists of rats given 5 ml “Celphos'mixture” (or 0.3mg/g body wt.). Group C consists of rats with acute Celphos poisoning along with Vitamin E (1.5 mg Vitamin E/g body weight of rat). Result: Mean serum creatinine concentration was significantly increased in both group B and group C as compared to group A. There is decrease in mean serum creatinine levels in acute ALP poisoning after vitamin E supplementation (group C) as compared to acute aluminium phosphide poisoning (group B), although this difference was not statistically significant. The rats were administered the doses via an infant feeding tube No. 8 and blood was obtained by Cardiac puncture one hour after feeding the dose. Serum Urea, serum creatinine and superoxide levels were estimated. The superoxide levels (nitroblue tetrazolium [NBT] reduction) were estimated. Mean serum urea concentration was significantly increased in both group B and group C as compared to group A. There is decrease in mean serum urea levels in acute ALP poisoning after vitamin E supplementation (group C) as compared to acute ALP poisoning (group B), although this difference was not statistically significant. NBT reduction was significantly increased in Group B as compared to Group A. Administration of Vitamin E to rats of Group C resulted in significant decrease of NBT reduction. Conclusion: Findings of the present study showed that Vitamin E via its antioxidant action and anti-inflamatory effects has protective effect on phosphine-induced toxicity in rats

Effect of vitamin E supplementation on superoxide and malondialdehyde generation in acute celphos poisoning

Introduction: Aluminum phosphide is one of the most commonly used grain fumigants and aluminum phosphide poisoning (ALP) has been reported as the most common cause of acute poisoning in India. Aluminum toxicity has been reported to increase the rate of lipid peroxidation and free radical formation. Materials and Methods: The present study was designed to investigate the role of vitamin E supplementation on free radical generation and lipid peroxidation in acute aluminium phosphide poisoning in rats. Thirty disease free albino rats were taken to study the effect of acute aluminium phosphide poisoning (ALP poisoning) were further divided into 3 subgroups of ten rats each: A, B and C. Group A: given vehicle (Ginni Oil) only. Group B: given 5 ml 'celphos mixture' (or 0.3mg/g body wt.). Group C: rats with acute Celphos poisoning along with vitamin E (1.5 mg vitamin E/g body weight of rat. The MDA levels and superoxide levels (Nitroblue tetrazolium (NBT) reduction) were estimated. Results: MDA levels were significantly higher in the group B as compared to Group A. In group C, administration of vitamin E resulted in decreased MDA level compared to group B. MDA levels in group C still remained significantly higher as compared to group A. NBT reduction was significantly increased in group B as compared to group A. Administration of vitamin E to rats of group C resulted in significant decrease of NBT reduction. Conclusion: Findings of the present study showed that vitamin E via its antioxidant action and anti-inflammatory effects has protective effect on phosphine-induced toxicity in rats

Comparative assessment of the performance of long period fiber grating-based biosensors

Evanescent wave-based optical fiber biosensors consisting of long period grating (LPG) are presented. A chemical or a biochemical interaction taking place on a conveniently treated surface causes a refractive index (RI) change that can be evaluated using optical approaches. By implementing the same antibody/antigen (IgG/anti-IgG) assay protocol in the same experimental conditions, a comparative assessment of the biosensor performance was carried out by using different types of LPGs (standard, turn-around point and coated) in which the coupling occurred with different cladding modes. These sensors were firstly characterized in terms of volume (or bulk) RI sensitivity, which just provides an indication of the biosensor performance, and then of detection limit (LOD), which in turn represents a real and effective analytical parameter of biosensors extrapolated from their calibration curves. LODs of the order of μg L-1 (10-11 M) were achieved for turn-around point and coated LPGs both in buffer and in serum as real and complex matrix, thus also proving the biosensor specificity

Cladocera of Malaysia and Singapore with new records, redescriptions, and remarks on some species

An intensive and extensive sampling of the zooplankton from East and West Malaysia and Singapore yielded 63 cladoceran species of which 26 are recorded for this region for the first time. Redescriptions of a few species are given together with remarks on some others. The records include the first known occurrence of Alonella nana, Chydorus faviformis and Streblocercus pygmaeus in the tropics. The most diverse fauna was found in rice fields and ponds. The species composition is typical for a tropical region and lacks the families Polyphemidae, Leptodoridae and Holopedidae. Also Daphnia was extremely rare

Subjective Well-Being, Poverty and Ethnicity in South Africa: Insights from an Exploratory Analysis

multiple correspondence analysis, poverty, South Africa, subjective well-being,