5 research outputs found
Clinical outcome of patients with Helicobacter pylori infection: the bug, the host, or the environment?
It is well established that only a minority of patients with Helicobacter pylori infection develop severe inflammation leading to peptic ulcer or gastric cancer. Recent evidence suggests that the virulence factors of the organism do not seem crucial in the progression of inflammation towards a more severe disease. It seems probable that other host derived and environmental factors are more significant in determining clinical outcome but additional studies are needed to clarify the underlying mechanisms involved in the pathogenesis of infection
Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study
Background. The aim of this study was to determine the value of
small-bowel preparation for patients undergoing capsule endoscopy.
Methods: The study design was prospective, randomized, and controlled.
Eighty patients referred for capsule endoscopy were randomized into two
equal groups. Patients in Group A (mean age 54.40 [15.65] years)
ingested 2 L of a polyethylene glycol/electrolyte solution 16 hours
before the test, whereas patients in Group B (mean age 59.85 [14.58]
years) prepared for the procedure by taking only clear liquids during
the prior day. The primary outcome evaluated was the effect of bowel
preparation on the quality of capsule images, as assessed with an
objective scoring system in which cleansing was graded as “adequate”
or “inadequate” by blinded examiners. A secondary outcome was the
effect of bowel preparation on diagnostic yield. For this purpose, the
results of capsule endoscopy were classified as positive findings,
findings of uncertain significance, and no findings.
Results: Cleansing of the small intestine was considered “adequate”
in 36 patients in Group A (90%) vs. 24 patients of Group B (60%) (p =
0.004). A diagnosis was established in 26 patients in Group A (65%)
compared with 12 patients in Group B (30%) (p = 0.003).
Conclusions: Bowel preparation before capsule endoscopy improves
visualization of the small intestine, which may lead to an improvement
in diagnostic yield