780 research outputs found
Variable-delay feedback control of unstable steady states in retarded time-delayed systems
We study the stability of unstable steady states in scalar retarded
time-delayed systems subjected to a variable-delay feedback control. The
important aspect of such a control problem is that time-delayed systems are
already infinite-dimensional before the delayed feedback control is turned on.
When the frequency of the modulation is large compared to the system's
dynamics, the analytic approach consists of relating the stability properties
of the resulting variable-delay system with those of an analogous distributed
delay system. Otherwise, the stability domains are obtained by a numerical
integration of the linearized variable-delay system. The analysis shows that
the control domains are significantly larger than those in the usual
time-delayed feedback control, and that the complexity of the domain structure
depends on the form and the frequency of the delay modulation.Comment: 13 pages, 8 figures, RevTeX, accepted for publication in Physical
Review
Minimizers with discontinuous velocities for the electromagnetic variational method
The electromagnetic two-body problem has \emph{neutral differential delay}
equations of motion that, for generic boundary data, can have solutions with
\emph{discontinuous} derivatives. If one wants to use these neutral
differential delay equations with \emph{arbitrary} boundary data, solutions
with discontinuous derivatives must be expected and allowed. Surprisingly,
Wheeler-Feynman electrodynamics has a boundary value variational method for
which minimizer trajectories with discontinuous derivatives are also expected,
as we show here. The variational method defines continuous trajectories with
piecewise defined velocities and accelerations, and electromagnetic fields
defined \emph{by} the Euler-Lagrange equations \emph{% on} trajectory points.
Here we use the piecewise defined minimizers with the Li{\'{e}}nard-Wierchert
formulas to define generalized electromagnetic fields almost everywhere (but on
sets of points of zero measure where the advanced/retarded velocities and/or
accelerations are discontinuous). Along with this generalization we formulate
the \emph{generalized absorber hypothesis} that the far fields vanish
asymptotically \emph{almost everywhere%} and show that localized orbits with
far fields vanishing almost everywhere \emph{must} have discontinuous
velocities on sewing chains of breaking points. We give the general solution
for localized orbits with vanishing far fields by solving a (linear) neutral
differential delay equation for these far fields. We discuss the physics of
orbits with discontinuous derivatives stressing the differences to the
variational methods of classical mechanics and the existence of a spinorial
four-current associated with the generalized variational electrodynamics.Comment: corrected minor typo: piecewise differentiable on closed instead of
open interval
Dutch Nao Team: Team description paper: Standard Platform League: German Open 2010
This is the debut of the Dutch Nao Team in the Standard Platform League. The team is a recreation of the Dutch Aibo Team, which was active in the predecessor of the SPL (2004-2006). This year participation is mainly intended to gain experience. As basis for the competition the code release of B-Human is used, with two modifications. The first modification is improved kicking behavior to accommodate the new ball. The second modification is two use both Nao cameraâs (one for ball control and one for localization)
Chromatid Segregation at Anaphase Requires the barren Product, a Novel Chromosome-Associated Protein That Interacts with Topoisomerase II
AbstractWe have isolated a Drosophila gene, barren (barr), required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologs in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphaseâanaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. This phenotype is similar to that described in TOP2 mutants in yeast. Barren protein localizes to chromatin throughout mitosis. Colocalization and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. We propose that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase
Synthesizing SystemC Code from Delay Hybrid CSP
Delay is omnipresent in modern control systems, which can prompt oscillations
and may cause deterioration of control performance, invalidate both stability
and safety properties. This implies that safety or stability certificates
obtained on idealized, delay-free models of systems prone to delayed coupling
may be erratic, and further the incorrectness of the executable code generated
from these models. However, automated methods for system verification and code
generation that ought to address models of system dynamics reflecting delays
have not been paid enough attention yet in the computer science community. In
our previous work, on one hand, we investigated the verification of delay
dynamical and hybrid systems; on the other hand, we also addressed how to
synthesize SystemC code from a verified hybrid system modelled by Hybrid CSP
(HCSP) without delay. In this paper, we give a first attempt to synthesize
SystemC code from a verified delay hybrid system modelled by Delay HCSP
(dHCSP), which is an extension of HCSP by replacing ordinary differential
equations (ODEs) with delay differential equations (DDEs). We implement a tool
to support the automatic translation from dHCSP to SystemC
pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
Mutations in the Drosophila gene pavarotti result in the formation of abnormally large cells in the embryonic nervous system. In mitotic cycle 16, cells of pav mutant embryos undergo normal anaphase but then develop an abnormal telophase spindle and fail to undertake cytokinesis. We show that the septin Peanut, actin, and the actin-associated protein Anillin, do not become correctly localized in pav mutants. pav encodes a kinesin-like protein, PAVâKLP, related to the mammalian MKLP-1. In cellularized embryos, the protein is localized to centrosomes early in mitosis, and to the midbody region of the spindle in late anaphase and telophase. We show that Polo kinase associates with PAVâKLP with which it shows an overlapping pattern of subcellular localization during the mitotic cycle and this distribution is disrupted in pavmutants. We suggest that PAVâKLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins
pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
Mutations in the Drosophila gene pavarotti result in the formation of abnormally large cells in the embryonic nervous system. In mitotic cycle 16, cells of pav mutant embryos undergo normal anaphase but then develop an abnormal telophase spindle and fail to undertake cytokinesis. We show that the septin Peanut, actin, and the actin-associated protein Anillin, do not become correctly localized in pav mutants. pav encodes a kinesin-like protein, PAVâKLP, related to the mammalian MKLP-1. In cellularized embryos, the protein is localized to centrosomes early in mitosis, and to the midbody region of the spindle in late anaphase and telophase. We show that Polo kinase associates with PAVâKLP with which it shows an overlapping pattern of subcellular localization during the mitotic cycle and this distribution is disrupted in pavmutants. We suggest that PAVâKLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins
Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism : a pooled analysis of the EINSTEIN-DVT and PE randomized studies
Background: Standard treatment for venous thromboembolism (VTE) consists of a heparin combined with vitamin K antagonists. Direct oral anticoagulants have been investigated for acute and extended treatment of symptomatic VTE; their use could avoid parenteral treatment and/or laboratory monitoring of anticoagulant effects.
Methods: A prespecified pooled analysis of the EINSTEIN-DVT and EINSTEIN-PE studies compared the efficacy and safety of rivaroxaban (15 mg twice-daily for 21 days, followed by 20 mg once-daily) with standard-therapy (enoxaparin 1.0 mg/kg twice-daily and warfarin or acenocoumarol). Patients were treated for 3, 6, or 12 months and followed for suspected recurrent VTE and bleeding. The prespecified noninferiority margin was 1.75.
Results: 8282 patients were enrolled. 4151 received rivaroxaban and 4131 received standard-therapy. The primary efficacy outcome occurred in 86 rivaroxaban-treated patients (2.1%) compared with 95 (2.3%) standard-therapy-treated patients (hazard ratio, 0.89; 95% confidence interval [CI], 0.66-1.19; pnoninferiority<0.001). Major bleeding was observed in 40 (1.0%) and 72 (1.7%) patients in the rivaroxaban and standard-therapy groups, respectively (hazard ratio, 0.54; 95% CI, 0.37-0.79; p=0.002). In key subgroups, including fragile patients, cancer patients, patients presenting with large clots and those with a history of recurrent VTE, the efficacy and safety of rivaroxaban was similar compared with standard-therapy.
Conclusion: The single-drug approach with rivaroxaban resulted in similar efficacy to standard-therapy and was associated with a significantly lower rate of major bleeding. Efficacy and safety results were consistent among key patient subgroups
Proprioceptor Pathway Development Is Dependent on MATH1
AbstractThe proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway
- âŠ