Aerogeni kontaktni dermatitis uzrokovan 2-amino-2-metil-1-propanolom u tvornici kozmetike

The authors described two cases of airborne contact dermatitis caused by 2-amino-2-methyl-1-propanol (AMP 100) in two subjects with periorbital erythema and itching skin. The AMP 100 has been used to replace ammonia as a hair dye component in the cosmetic industry with the purpose to eliminate its smell. Patch tests proved positive only to dilutions of 10% and 20% in the two described patients, as well as in other six asymptomatic subjects operating in the same working environment. The authors have diagnosed an irritative airborne contact dermatitis by AMP 100.Aerogeni kontaktni dermatitis pojavljuje se kao iritacija ili kao alergija. Uzrokuju ga brojni agensi, od kojih su gotovo svi uobičajeni za radni okoliš u proizvodnji kozmetike. Alergije su relativno ceste a lezije su gotovo uvijek simetrično raspoređene po licu, vratu i rukama, odnosno pod pazuhom i na preponama. Dosada, međutim, nije zabilježen niti jedan slučaj aerogenog kontaktnog dermatitisa uzrokovanog 2-amino-2-metil-1-propanolom [AMP 100) koji je uveden kao zamjena za amonijak u proizvadnji lakova i boja za kosu. Ovaj rad opisuje dva zabilježena slučaja aerogenog kontaktnog dermatitisa uzrokovanog AMP-om 100 u pacijenata s periorbitalnim eritemom i svrbežom. Reakcije na epikutano alergijsko testiranje pokazale SL se pozitivnima samo s otopinama od 10% i 20%, i to ne samo u dvoje opisanih pacijenata nego i u šest ispitanika koji nisu iskazivali simptome a radili su na istome radnom mjestu. Autori su pritom dijagnosticirali iritativni oblik aerogenoga kontaktnog dermatitisa uzrokovanog AMP-om 100. Stoga autori vjeruju da bi AMR 100 trebalo dodati zamjetnoj listi proizvoda koji uzrokuju aerogeni Kontaktni dermatitis u kozmetičkoj industriji, štoviše, zbog stalne uporabe AMP-a 100 u frizerskim salonima trebalo bi obratiti pozornost na zaštitu od njegovih učinaka na frizere

A Chemical-Biological Study Reveals C-9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors

The potential of heat shock protein 90 (Hsp90) as a therapeutic target for numerous diseases has made the identification and optimization of novel Hsp90 inhibitors an emerging therapeutic strategy. A surface plasmon resonance (SPR) approach was adopted to screen some iridoids for their Hsp90 alpha binding capability. Twenty-four iridoid derivatives, including 13 new natural compounds, were isolated from the leaves of Tabebuia argentea and petioles of Catalpa bignonioides. Their structures were elucidated by NMR, electrospray ionization mass spectrometry, and chemical methods. By means of a panel of chemical and biological approaches, four iridoids were demonstrated to bind Hsp90 alpha. In particular, the dimeric iridoid argenteoside A was shown to efficiently inhibit the chaperone in biochemical and cellular assays. Our results disclose C-9-type iridoids as a novel class of Hsp90 inhibitors