7 research outputs found
Physical Activity Participation among Caribbean Hispanic Women Living in New York: Relation to Education, Income, and Age
No full text
Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products
No full textThe association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences
No full textNavigating CAR-T cells through the solid-tumour microenvironment
No full textThe adoptive transfer of T cells that are engineered to express chimeric antigen receptors (CARs) has shown remarkable success in treating B cell malignancies but only limited efficacy against other cancer types, especially solid tumours. Compared with haematological diseases, solid tumours present a unique set of challenges, including a lack of robustly expressed, tumour-exclusive antigen targets as well as highly immunosuppressive and metabolically challenging tumour microenvironments that limit treatment safety and efficacy. Here, we review protein- and cell-engineering strategies that seek to overcome these obstacles and produce next-generation T cells with enhanced tumour specificity and sustained effector function for the treatment of solid malignancies
