Series voltage regulator for radial DC-microgrid

The concept of a novel series voltage regulator (SVR) for controlling the dc-bus voltage of a radial dc microgrid is presented in this paper. The proposed SVR uses a dual-active-bridge dc-dc converter followed by a full-bridge dc-dc converter. It injects dynamic voltage in series with the dc grid to compensate resistive drop over the network. As a result, the voltage level at the different points of the grid becomes independent of load variation and stays within the specified limit. Note that the required power rating of the SVR is very low (say 2.7%) compared to the load demand considering 5% voltage regulation. In this paper, the voltage regulator is connected at the midpoint of the grid, but it may be connected in some other locations to get optimal rating of the same. The proposed configuration is simulated in MATLAB/SIMULINK at a 380-V level to check the dynamic performance under various operating conditions. A scaled-down version (at 30-V level) of the proposed system is developed in the laboratory to experimentally validate the concept. The results show the effectiveness of such a voltage regulator for the radial dc microgrid, especially under critical load condition

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

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