A review of the epidemiology of oral and pharyngeal carcinoma: update

Oral and pharyngeal cancers are the sixth most common cancers internationally. In the United States, there are about 30,000 new cases of oral and pharyngeal cancers diagnosed each year. Furthermore, survival rates for oral and pharyngeal cancers have not significantly improved over the last three decades. This review examines the scientific literature surrounding the epidemiology of oral and pharyngeal cancers, including but not limited to risk factors, disparities, preventative factors, and the epidemiology in countries outside the United States. The literature review revealed that much of the research in this field has been focused on alcohol, tobacco, and their combined effects on oral and pharyngeal cancers. The literature on oral and pharyngeal cancer disparities among racial groups also appears to be growing. However, less literature is available on the influence of dietary factors on these cancers. Finally, effective interventions for the reduction of oral and pharyngeal cancers are discussed

Minute virus of mice inhibits cell transformation by simian virus 40.

Certain paroviruses have been reported to inhibit spontaneous or virus-induced tumorigenesis in rodents; the mechanisms of this antineoplastic activity is unknown. We have investigated the ability of the minute virus of mice (MVM), a non-defective paravirus, to interfere with the in vitro transformation of mouse cells by simian virus 40 (SV40). We used variants of BALB/c 3T3 cells, denoted PVR, selected for their resistance to the lytic effect of MVM. We report here that inoculation of SV40-infected PVR cells with MVM reduced dramatically the yield of transformed clones. Moreover, stable SV40 transformants of PVR cells lost up to 85% of their ability to grow in soft agar after MVM infection. Our results indicate that the antineoplastic effect of parvoviruses can be simulated in cell cultures and may involve a direct and selective toxic effect of these viruses on malignant cells or their precursors.SCOPUS: ar.jinfo:eu-repo/semantics/publishe