3 research outputs found
The protective effects of acetyl L-carnitine which added into HistidineTryptophan-Ketoglutarate solution on donor uterus
Objective: At the present times uterus transplantation is an alternative therapy for women with untreatable uterine-based
infertility factors. Before transplantation, the donor organ must stored in some solutions, but they may not adequate for
protection. In this study, we investigated the potential protective effects of acetyl L-carnitine, added into histidine-tryptophanketoglutarate
(HTK) solution, on rat uterus.
Methods: We divided 24 female Wistar Albino rats into four groups (n=6). Their uterine tissues were stored into four different
solutions at different periods at 4oC ; Group 1 HTK, 4 hours; Group 2. HTK + acetyl L- carnitine, 4 hours, Group 3. HTK, 24 hours;
Group 4. HTK + acetyl L- carnitine, 24 hours. Then tissues from uterus were used for histological and biochemical examination.
Results: In the study the number of TUNEL positive cells in group 4 was lower than group 3. Biochemically evaluated TBARS and
NOS levels were highest in group 3 however CAT level was highest in group 2.
Conclusion: In conclusion, addition of acetyl L-carnitine to HTK solution reversed the histological alterations after 24 hours cold
storage on rat uterus
Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus
AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE)