The Physical State of the Intergalactic Medium or Can We Measure Y?

We present an argument for a {\it lower limit} to the Compton-$y$ parameter describing spectral distortions of the cosmic microwave background (CMB). The absence of a detectable Gunn-Peterson signal in the spectra of high redshift quasars demands a high ionization state of the intergalactic medium (IGM). Given an ionizing flux at the lower end of the range indicated by the proximity effect, an IGM representing a significant fraction of the nucleosynthesis-predicted baryon density must be heated by sources other than the photon flux to a temperature \go {\rm few} \times 10^5\, K. Such a gas at the redshift of the highest observed quasars, $z\sim 5$, will produce a y\go 10^{-6}. This lower limit on $y$ rises if the Universe is open, if there is a cosmological constant, or if one adopts an IGM with a density larger than the prediction of standard Big Bang nucleosynthesis.Comment: Proceedings of `Unveiling the Cosmic Infrared Background', April 23-25, 1995, Maryland. Self-unpacking uuencoded, compressed tar file with two figures include

Innovation in incapacity: education, technique, subject

Abstract This essay addresses the question of change as it is expressed in debates on the introduction and use of new digital technologies in contemporary education. It sets out some of the terms of this debate, concerning MOOCs in particular, and puts into question the very conception of change they presume. The essay advocates a distinction between education, which marks the subjective capacity of all for thought, and pedagogy, which, the essay argues, teaches subjective incapacity for all. The case is made that without a formal conception of change MOOCs will only strengthen the contemporary pedagogical project of difference as repetition. In conclusion, the essay attempts to sketch a conception of real change such that a new orientation to the debate is proposed

Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase complex

Higher eukaryotes have developed extensive compartmentalization of amino acid (aa) - tRNA coupling through the formation of a multi-synthetase complex (MSC) that is composed of eight aa-tRNA synthetases (ARS) and three scaffold proteins: aminoacyl tRNA synthetase complex interacting multifunctional proteins (AIMP1, 2 and 3). Lower eukaryotes have a much smaller complex while yeast MSC consists of only two ARS (MetRS and GluRS) and one ARS cofactor 1 protein, Arc1p (Simos et al., 1996), the homolog of the mammalian AIMP1. Arc1p is reported to form a tripartite complex with GluRS and MetRS through association of the N-terminus GST-like domains (GST-L) of the three proteins (Koehler et al., 2013). Mammalian AIMP1 has no GST-L domain corresponding to Arc1p N-terminus. Instead, AIMP3, another scaffold protein of 18 kDa composed entirely of a GST-L domain, interacts with Methionyl-tRNA synthetase (MARS) (Quevillon et al., 1999) and Glutamyl-Prolyl-tRNA Synthetase (EPRS) (Cho et al., 2015). Here we report two new interactions between MSC members: AIMP1 binds to EPRS and AIMP1 binds to AIMP3. Interestingly, the interaction between AIMP1 and AIMP3 complex makes it the functional equivalent of a single Arc1p polypeptide in yeast. This interaction is not mapped to AIMP1 N-terminal coiled-coil domain, but rather requires an intact tertiary structure of the entire protein. Since AIMP1 also interacts with AIMP2, all three proteins appear to compose a core docking structure for the eight ARS in the MSC complex

Differential Privacy and the Fat-Shattering Dimension of Linear Queries

In this paper, we consider the task of answering linear queries under the constraint of differential privacy. This is a general and well-studied class of queries that captures other commonly studied classes, including predicate queries and histogram queries. We show that the accuracy to which a set of linear queries can be answered is closely related to its fat-shattering dimension, a property that characterizes the learnability of real-valued functions in the agnostic-learning setting.Comment: Appears in APPROX 201

Political Orientation and the Decision to Major in Economics: Some Preliminary Observations

Studies find that students major in economics for a variety of reasons. None, however, have examined students' political orientations as a possible factor in their choice of majors. Economics, as compared to other social sciences, tends to produce conservative policy recommendations. This pilot study explores whether more conservative students are attracted to economics. Our study found that men with conservative political leanings are more likely to major in economics and that male students in economics are more conservative than female students. Political orientation, however, does not appear to be a significant factor in the choice of a major for women.

At what chain length do unbranched alkanes prefer folded conformations?

Short unbranched alkanes are known to prefer linear conformations, while long unbranched alkanes are folded. It is not known with certainty at what chain length the linear conformation is no longer the global minimum. To clarify this point, we use {\it ab initio} and density functional methods to compute the relative energies of the linear and hairpin alkane conformers for increasing chain lengths. Extensive electronic structure calculations are performed to obtain optimized geometries, harmonic frequencies and accurate single point energies for the selected alkane conformers from octane through octadecane. Benchmark CCSD(T)/cc-pVTZ single point calculations are performed for chains through tetradecane, while approximate methods are required for the longer chains up to octadecane. Using frozen natural orbitals to unambiguously truncate the virtual orbital space, we are able to compute composite CCSD FNO(T) single point energies for all the chain lengths. This approximate composite method has significant computational savings compared to full CCSD(T) while retaining $\sim0.15$ kcal/mol accuracy compared to the benchmark results. More approximate dual-basis resolution-of-the-identity double-hybrid DFT calculations are also performed and shown to have reasonable $0.2-0.4$ kcal/mol errors compared with our benchmark values. After including contributions from temperature dependent internal energy shifts, we find the preference for folded conformations to lie between hexadecane and octadecane, in excellent agreement with recent experiments [L\"{u}ttschwager, N. O.; Wassermann, T. N.; Mata, R. A.; Suhm, M. A. {\it Angew. Chem. Int. Ed.} 2013, 52, 463]