Methods for Diagnosing Some Malignant Neoplasms of the Canine Nasal Mucosa

AbstractThe aim of this study is to highlight the easiest method of investigation (nasal lavage or rhinoscopy) depending on the animal condition. 18 dogs were investigated, which presented at the Faculty of Veterinary Medicine Bucharest, with respiratory distress due to obstruction of the nasal cavities. The sampling for cytological diagnosis was done using the two techniques, the nasal lavage and rhinoscopy. It is most useful to try the lavage first, because it is less invasive, and only then, if case of poor cellularity after centrifugation, or in case of a inflammatory process with unfavourable post-treatment evolution, endoscopy will be used. Cytomorphological diagnosis using, after rhinoscopy or nasal lavage, have evidentiated the following forms of nasal cancer: 10 cases out of 18 were epithelial neoplasms of the olfactory mucosa; 6 cases out of 18 were nerve tumors (malignant melanoma, estesiocarcinoma); 2 cases out of 18 were mesenchymal tumors (osteosarcoma, fibrosarcoma). The nasal lavage is a good sampling method but has the disadvantage of sometimes encountering an acute or chronic inflammatory process that can shield the tumor process

Tools for Objectifying Motor Assessment and Functional Adaptability of Children with SEN in Special Education

The motric activities for children who have special educational needs (SEN) are adapted and individualized to their deficiencies. It is also considered that the development of motor skills facilitates their participation in various educational activities carried out at school, thus providing some learning opportunities. The article analyzes the way motor abilities influence the children with SEN in the school adaptation. The research was conducted between January and February 2022 at the School Center for Inclusive Education Brașov (Romania). The study included 8 subjects with intellectual disabilities (ID) and associated disabilities, with an average age of 5.8 years (SD = 1.3). The motor skills test was performed by applying Movement Assessment Battery for Children, Second Edition (M ABC-2), using evaluation items for balance, manual dexterity and for throwing and catching objects. School functionality was assessed by the School Function Assessment (SFA), through which the ability to perform the physical and cognitive-behavioral tasks of the children concerned was determined. The results obtained showed a significant connection (r= .934) between the variable of motor skills and the variable of school functionality, which leads us to conclude that motor skills can improve the functional adaptation of children with SEN to activities in the school environment.</p

Verhandeln, Überwachen und Empfehlen von Datenverträgen in IdD Datenräume

Abweichender Titel nach Übersetzung der Verfasserin/des VerfassersZusammenfassung in deutscher SpracheMit den technologischen Fortschritten der letzten Jahre sind im Bereich des Internet der Dinge (IdD) die Anzahl an verbundenen Geräten, und die dadurch produzierte Datenmenge, drastisch gestiegen. Mehrere IdD Plattformen wurden erstellt um den Kauf bzw. Verkauf von Daten zu ermöglichen. Diese sind jedoch eingeschränkt in Bezug auf der Vertragsgründung und Vertragsverwaltung. Zum Beispiel wird das Verhandeln von individuellen Datenverträgen nicht unterstützt, ebenso wie das Überwachen des Datenflusses und das Empfehlen neuer Verträge. Die Herausforderung hier ist, dass unterschiedliche Datenverträge, für die produzierten Daten von einem Ding, abgeschlossen werden können. Eine weitere Herausforderung ist das Überwachen des Datenflusses für Datenverträge: Ein Vertrag kann aus Daten bestehen, die von beliebigen Dingen erstellt werden und jedes Ding kann unterschiedliche Daten produzieren. Diese Arbeit stellt ein erweiterbares und skalierbares IdD vertragsbewusstes Framework vor, welches das Verhandeln von individuellen Datenverträgen, die Überwachung des Datenflusses für Datenverträge und Empfehlungen anbietet. Der methodische Ansatz dieser Arbeit ist in drei Teilen eingeteilt. Im ersten Teil wird eine Literaturrecherche durchgeführt um mögliche Schlüsselelemente für das Erstellen, Überwachen und Empfehlen von Datenverträgen zu identifizieren. Basierend auf diesen Ergebnissen werden Anforderungen für die Implementierung eines Frameworks erstellt. Im zweiten Teil werden ein Framework und ein Prototyp als Konzeptnachweis erstellt. Im letzten Teil wird der Prototyp mittels zwei Methoden ausgewertet: einer deskriptiven Analyse, um den Nutzen des Prototyps zu demonstrieren und einer dynamischen Analyse um die Stabilität und Zuverlässigkeit des Prototyps zu beweisen. Die resultierenden Ergebnisse beweisen die Effektivität des vorgestellten Frameworks bei dem Verhandeln, Überwachen und Empfehlen von Datenverträgen in IdD Datenräumen.With the technological advances from the past few years in the Internet of Things (IoT) the number of interconnected devices has increased drastically together with the amounts of produced data. Multiple IoT platforms have been created to facilitate IoT data purchasing and selling. These platforms are limited regarding the data contract establishment and management. For example current platforms do not support the negotiation of individual data contracts,the monitoring of the data flow and making recommendations. The challenge here is that different data contracts can be concluded for data produced by the same Thing. Another challenge is the monitoring of the data flow for data contracts: a data contract can consist of data produced by many Things, where each Thing can produce entirely different data. This thesis introduces a new extensible IoT contract-aware framework, which supports the individual establishment of data contracts, the monitoring of the data flow for data contracts and making recommendations. The methodological approach of this thesis is divided into three parts. In the first part literature research is conducted in order to find possible key elements regarding the design, monitoring and recommendation of data contracts. Based on these findings requirements are extracted for the implementation of a framework. In the second part a framework and a prototype as a proof of concept are implemented. Finally, in the last part, the implemented prototype is evaluated using two evaluation methods: a descriptive analysis to demonstrate the utility of the prototype and a dynamic analysis to demonstrate the performance and reliability of the prototype. The obtained results demonstrate the effectiveness of the introduced framework for negotiating, monitoring and recommending data contracts in IoT dataspaces.8

NOREX: A Distributed Reengineering Environment

Several reengineering environments have been created to provide for a unified infrastructure in which various approaches can be employed together. While the collaboration between tools is very strong within such environments, currently the inter-environmental collaboration is very weak and happens mainly at the level of data-files exchange. Consequently, the different groups of researchers are only collaborating shallowly via data, rather than at the level of analysis. In this demo, we present NOREX, a distributed reengineering environment that allows different groups of researchers to transparently use and combine existing techniques, and share their own, transcending any parochial barriers (e.g., implementation language or environment).

Current trends in scientific research in IT and Electrical and Electronics Engineering

From the vast research and development subjects in IT and Electrical and Electronics Engineering, some of the most important of them have been selected and are presented in this paper. Arguments that justify the chosen of these subjects among the most important in present are presented. The main selection criteria are the relevance for the current trends in these industries and the funding availability to insure the transition from theoretical and experimental research into practical applications. It might also help college students in shaping their preferences for a successful engineering carrier. Before approaching the specifics of the selected subjects the paper illustrates the interplay between learning strategies and scientific epistemological views to help framing an attitude toward science

p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women under 30 years old

Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunohistochemical staining can also be used for the detection of oncogenic changes in cervical cells. Our aim was to compare the performance of p16/Ki-67 dual staining and HPV genotyping in the detection of high-grade cervical lesions in patients with atypical squamous cells of undetermined significance (ASCUS)/low-grade squamous intraepithelial lesion (LSIL) on Pap smear. We retrospectively analyzed 310 patients with ASCUS/LSIL on Pap smear, who underwent colposcopy. Among these, 161 patients with suspected lesions detected by colposcopy were referred to biopsy. HPV genotyping by LINEAR ARRAY HPV Genotyping Test (CE-IVD) and p16/Ki-67 dual staining by CINtec PLUS Cytology kit was performed prior to cervical biopsy. The overall sensitivity and specificity of HPV genotyping for the detection of cervical intraepithelial neoplasia (CIN) 2-3 was 79% and 72%, respectively in patients with ASCUS, and 85% and 64%, respectively in patients with LSIL. For p16/ki-67 test, sensitivity and specificity rate was 66% and 93%, respectively in ASCUS and 59% and 79%, respectively in LSIL group. The specificity of p16/Ki-67 staining was significantly higher in both groups in patients aged 30 years old (p < 0.001). Our results showed that p16/Ki-67 dual staining has a higher specificity compared to HPV genotyping, especially in patients under 30 years old. This indicates the usefulness of p16/Ki-67 testing in the triage of patients with ASCUS/LSIL and <30 years old, prior to the referral to colposcopy and biopsy

Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-gamma-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development