A phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging

Background: Elacestrant is an oral selective estrogen receptor (ER) degrader. This phase 1b open-label, nonrandomized study (RAD1901-106) was initiated to determine the effect of elacestrant on the availability of ER in lesions from postmenopausal women with ER+ advanced breast cancer (ABC) using 16α18F-fluoro-17β-estradiol positron emission tomography with low-dose computed tomography (FES-PET/CT). Methods: Eligible patients were postmenopausal women with ER+, HER2− ABC; tumor progression after ≥ 6 months of 1–3 lines of endocrine treatment for ABC; and measurable or evaluable disease. Two 8-patient cohorts were enrolled: one treated with 400 mg elacestrant once daily (QD) and one treated with 200 mg elacestrant QD with dose escalation to 400 mg QD after 14 days. Elacestrant was dosed continuously until progressive disease, toxicity, or withdrawal. FES-PET/CT was performed pre-dose at baseline and 4 h post-dose on day 14. The primary endpoint was the percentage difference in FES uptake in tumor lesions (maximum 20) after 14 days of treatment compared to baseline. Overall response was investigator-assessed by Response Evaluation Criteria in Solid T

Bathymetric distribution of some benthic and benthopelagic species attracted to baited cameras and traps in the deep eastern Mediterranean

A series of baited camera and trap experiments in the eastern Mediterranean Sea between 1500 and 4264 m depth attracted a variety of opportunistic scavengers, with species composition changing with increasing depth. At the shallower stations (1500 to 1800 m), decapod crustaceans and fishes, dominated by elasmobranchs such as Hexanchus griseus, were attracted to and actively consumed the bait. Some of these species were observed at depths exceeding their previously reported ranges. This was believed to be a result of the absence of deep-water scavengers from the adjacent Atlantic due to dispersal barriers and elevated temperatures at depth. The diversity of bait-attending fauna declined with increasing depth. Elasmobranchs were not observed below 2500 m, and below 4000 m only the caridean shrimp Acanthephyra eximia and the macrourid Chalinura mediterranea were present; at this latter depth, bait consumption was negligible. This shift in species composition was reflected in changes in first arrival times. Increasing first arrival times of H. griseus suggested a decline in relative abundance from 1500 to 2500 m, whilst those of C. mediterranea indicated an increase in relative abundance from 1800 to 4264 m