Clinical Features and Pattern of Presentation of Breast Diseases in Surgical Outpatient Clinic of a Suburban Tertiary Hospital in South-West Nigeria

Objective: To characterize the clinical features and pattern of presentation of breast diseases as observed in our practice. Materials and Methods: A prospective study of 121 consecutive patients with breast complaints presenting in our Surgical Outpatient Clinics. The relevant data were collected by two surgeons using the prescribed forms and was analyzed using Epi Info 2003, Mann–Whitney (test of two groups) Chi-squared and Fishers exact test was used to compare parameters of benign and malignant groups. P value <0.05 was considered as significant. Results: One hundred and nineteen patients were females, two were males. The age range was 14–70 years. Forty two (34.7%) patients were in the 21–30 year age group. The commonest symptoms were breast lump in 111 (91.7%) patients, and breast pain in 28 (23.1%) patients. Breast pain was a significant presenting complaint in patients with breast malignancy (P=.026). On clinical examination 103 (85.1%) patients had palpable lumps, and seven patients were normal. Forty four patients (36.3%) had malignant disease, seventy patients (57.8%) had benign breast diseases and seven were normal. Fifty nine of the 70 benign diseases were fibroadenoma. One hundred and three patients (85%) had appropriate therapy, while 18 patients (14.8%), including eight with malignant disease absconded. Conclusion: In the study, a breast lump was the commonest clinical feature of breast disease. Over 60% of these were benign. Breast pain was a statistically significant presentation in patients with malignant breast disease. One in seven of the patients absconded.Keywords: Breast lumps, breast malignancy, breast pain, fibroadenomaNigerian Journal of Surgery, Jan-Jun 2012 | Volume 18 | Issue

Evaluation of CD4+ T Cells in HIV Patients Presenting with Malaria at the University of Ilorin Teaching Hospital Nigeria

CD4 count is an important immunological marker of disease progression in HIV seropositive patients. This study was carried out to determine the effect of malaria or fever of unknown origin on the population of CD4+ T lymphocytes of HIV seropositive patients attending the highly active antiretroviral therapy (HAART) clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 36 subjects were selected for this study. Ongoing history of fever was used as a case definition for malaria and malaria was confirmed from microscopic examination of thick and thin film of blood sample obtained from the patients during presentation with fever. The CD4 count was evaluated during presentation of fever and post-fever using flow cytometry. There was significant decrease in CD4 count of the patients. However, upon classifying the patients into 2 groups - those that returned to the clinic after a week and those that returned after a month - a significant increase in CD4 count was noticed in the group that returned after a week, while a significant decrease was noticed in the group that returned after a month (at p value of 95%). Further classification of the patients based on presence of malaria parasite, and body temperature resulted in varying effects on CD4 count post-fever (in the general group, 27 were positive for malaria parasites. Of these 27, there was an increase in CD4 count in 9 (33.3%). However in the group that returned after a week, all 6 (100%) that were positive for malaria parasites showed increase in CD4 count. Five (26.3%) of the 19 patients that had body temperature within the range of 35.5-37.4^o^C showed an increase in CD4 count, while 7 (41.2%) the 17 patients that had body temperature of 37.5^o^C and above showed an increase in CD4 count. The results led to the conclusion that while some components of the immune response to malaria could strengthen the immune system of HIV seropositive patients by increasing their CD4 count, other components will suppress their immunity by decreasing their CD4 count, accelerating the progression to AIDS

Model uncertainty in characterizing recreation demand

A Bayesian variable selection procedure is used to control for uncertainty in the specification of a recreational demand model. Specifically, we propose a model that draws on the Bayesian paradigm to integrate the variable selection process into the model and reflect the accompanying uncertainty about which is the best specification used for counterfactual predictions. The advantage of this procedure over previous non-Bayesian approaches is that overcomes the problem of pre-testing in specification searches

Swarming modulatory effects of some amino acids on Proteus strains from Lagos, Nigeria

Swarming motility, a multicellular behaviour characterized by periodic concentric growth on solid media has severally been reported as a constraint in the clinical investigation of mixed-culture infections involving Proteus and as a requirement for virulence. While media are being formulated to restrain swarming in this organism, the roles played by amino acids in the biogenesis of swarming have not been fully clarified. The effects of 20 amino acids on swarming, extracellular protease activity, cellular RNA level and total protein concentration in 20 clinical Proteus strains from Lagos, Nigeria were investigated. At 0.5mM concentration, glutamine, serine, and methionine were the only amino acids found to enhance swarming motility on M9 minimal medium (7.1—11.3 mm), cause significant increases in protease activity (33.7—48.3 units/ml), total protein concentration (22.5—28.6 mg/ml) and cellular RNA concentration (192.8—264.7 mg/ml) when compared to values obtained for other 17 amino acids (P < 0.05). Furthermore, the amino acid induced swarming in these strains was found to vary directly and significantly (P < 0.05) with protease activity and cellular RNA concentration. The exclusion of methionine, serine and glutamine when supplementing antiswarming media for clinical investigation of Proteus - associated polymicrobial infections in Nigeria is suggested. (African Journal of Biotechnology: 2002 1(1): 10-16

EARTHWORM CAST BIOMASS UNDER THREE MANAGED ECOSYSTEMS: IMPLICATION FOR SOIL FERTILITY

The study was conducted to determine earthworm cast biomass under three managed ecosystems, Gmelina, Cashew and Banana plantations at Federal University of Agriculture, Abeokuta and its impact on the soil physicochemical parameters. Seven, five and four plots of 3 m2 each were sampled in Gmelina, Cashew and Banana plantations respectively. Each plot was laid out in form of a grid and seven quadrats of 44 cm x 44 cm each were sampled in each plot. On-field Cast weights were determined to the nearest gram using a top loading mechanical balance and the cast biomass was calculated from these. The nutrient and mineral properties of both earthworm casts and parent soils were determined using standard methods of AOAC. The % OC (4.61), %OM (7.96), sulphate (38.37), pH (7.78), total nitrogen (0.27), Mn (0.47) and Fe (7.23) were significantly higher (p&lt;0.05) in the earthworm casts under Gmelina plantation compared with the cashew and banana plantations. Cu and Fe concentrations in the parent soil under Gmelina plantation were significantly higher (p&lt;0.05) than under cashew and banana plantations while Mg and Mn concentrations showed no significant difference. Compared with the parent soil, %OC, %OM, Mn and Fe obtained from earthworm casts were significantly higher (p&lt;0.05) under all three plantations. Earthworm cast biomass under the Gmelina plantation (15483.63g/m2) was significantly (p&lt;0.05) higher than that obtained under the cashew (13270.83g/m2) and banana (8828.13) plantations. The present results showed that earthworm activity is better supported under Gmelina than cashew and banana plantations In addition, the higher cast biomass and nutrient level in the parent soil under Gmelina plantation signifies a significantly higher nutrient level which, expectedly means that the Gmelina plantation soil will be more fertile than the soil in cashew and banana plantations.Key Words: Earthworm cast, Gmelina, Cashew, Banana, physicochemica

Comparative evaluation of processes for production of soybean meal for poultry feed in Nigeria Evaluación comparativa de procesos para la producción de harina de soya para la alimentación de pollos en Nigeria

This work examined and compared three processes for production of low trypsin inhibitor soybean meal. Soybean flour was subjected to roasting, autoclaving and steaming to denature trypsin inhibitors. Roasting was done at 120, 130, 135 and 140 ºC for 5, 7, 8 and 9 minutes, respectively. Autoclaving was carried out at 121ºC, 15psig for 20, 30, 40 and 50 minutes. Steaming was carried out at 105 ºC for 10, 12, 15 and 18 minutes. Defatting of the samples was done and the activity of trypsin inhibitor was investigated. Proximate analysis and quality tests was carried out to ascertain quality of the heat treated soybean meals. Trypsin inhibitor in the soybean meals from the three heat treatment processes ranged from 1.20 to 3.54mg/g while that of raw sample was 6.01mg/g. Percentage crude protein in all the heat treated samples ranged from 39.38 to 40.58 % while that of raw sample was 44.60 %. Urease index ranged from 0.11 to 2.07 % for all heat treated samples while it was 2.11 % for the raw samples. % KOH protein solubility in Soybean meal from the three processes ranged from 45.2 to 73.1 % while that of the raw sample was 49.1%. The results were statistically significant at p>0.05. At significance level of p>0.05 it was established that local soybeans can be processed with adequate heat to obtain low activity soybean meal with good nutrient standard. The steaming process operated at 105 ºC for 18 minutes gave the best overall results with trypsin inhibitor activity of 1.20 mg/g

EFFECTS OF PRETREATMENT ON BIOBUTANOL YIELDS FROM RICE-BRAN AND DEOILED RICE-BRAN PROCESSED WITH Clostridium saccharoperbutylacetonicum N1-4

Acid and enzymatic pre-treatment of selected lignocellulosic materials [Rice Bran (RB) and Deoiled Rice Bran (DRB)] were conducted to facilitate the release of simple sugars for fermentation process leading to biofuel production. In this study, an innovative approach involving the use of acids to breakdown the complex lingo-cellulosic structure of&nbsp; RB and DRB was utilised. In addition, RB and DRB samples were&nbsp; subjected to physical (heat treatment) and enzymatic treatments, sequentially; in order to improve the amount of simple sugar available as substrate in a microorganism assisted fermentation process. The released sugar from the various treatment regimes were subjected to fermentation process. The highest total fermentable sugar obtained from the Trichloroacetic Acid (TCA), HCl and H2SO4 treated hydrolysate were 33.07 g L-1, 27.14 g L-1 and 31.93 g L-1 for treated hydrolysates, respectively. DRB samples showed a higher total sugar yields and fermentation products than RB samples. The highest butanol yield obtained from the TCA, HCl and H2SO4 treated hydrolysate were 8.66 g L-1, 5.32 g L -1 and 7.86 g L-1, respectively, after fermentation. The Acetone-Butanol-Ethanol (ABE) yield and productivity of the TCA, HCl and H2SO4 treated DRB hydrolysates were 0.47 g/g and 0.1g L-1 h-1, 0.32g/g, and 0.07 g L-1 h-1 as well as 0.42 g/g, and 0.08 g L-1 h-1, respectively. (This is consistent with Table 1) The high ABE yield and productivity values suggest that TCA is a good novel pre-treatment agent for biomass fermentation

Failure Evaluation of Aluminum Alloy in 2 M Hydrochloric Acid in the Presence of Cola acuminata

Hydrochloric acid induced damage of alwninwn alloy in the presence of Cola acuminata extract was investigated using gasometric technique. Alwninwn alloy coupons of dimension 4 em by 1 em were immersed in test solutions of free acid and also those containing extract concentrations of 2-5 cm3 at ambient temperature for 30 min. The volwnes of hydrogen gas evolved as a result of the reaction rate were recorded and analyzed. The outcome revealed that maximwn inhibitor efficiency which corresponds to the lowest corrosion rate was obtained at optimwn inhibitor concentration with reduction in the corrosion rate observed to follow in order of increasing extract concentration. The mechanism of interaction between the phytochemicals in the plant extract and ahnninlllll alloy swface was best described by the Fnnnkin isotherm with 6 and 14 min becoming the best exposure time for the phytochemicals in extract concentrations of 3-5 cm3 to suitably adsorb to metal alloy surface. Statistically modeling the corrosion rate yielded a significant relationship suitable for estimating corrosion rate values once concentration of the extract is known. In addition, the superficial analysis revealed that crack growth rate slowed do\Vll and irregular intermetallic phases were more mriform as extract concentration increased

Managing Credit Risk to Optimize Banks’ Profitability: A Survey of Selected Banks in Lagos State, Nigeria

This study examines the impact of managing credit risk and profitability of banks in Lagos state. It also focused on the need for prompt, effective and efficient service to numerous customers. The research hypothesis was tested and analyzed in relation to adequate credit risk management and its significant effect on banks’ profitability. It was also the aim of this research to evaluate how effective it is for a bank to manage its credit risk effectively to enhance profitability. In the course of this work, data was gotten through administering structured questionnaires which were answered by respondents. Correlation coefficient was used to decide whether or not credit risk management has an impact on profitability. It was then revealed through the analysis of data from the questionnaire that credit risk management operations plays a significant role in the profitability and performance of banks in Lagos State. Therefore, management need to be cautious in setting up a credit policy that might not negatively affects profitability and also they need to know how credit policy affects the operation of their banks to ensure judicious utilization of deposits. Keywords: Credit Risk, Managing, Banks Profitability, Performance, Utilization of Deposit