B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population

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Brief Report - Azithromycin as Treatment for Cryptosporidiosis in Human Immunodeficiency Virus Disease

Background: Cryptosporidiosis caused by the protozoa Cryptosporidium, is the common cause of diarrhoea in Acquired Immune Deficiency Syndrome (AIDS). Aim: To study the efficacy of short-term azithromycin in the management of cryptosporidiosis. Settings and Design: Randomised, controlled trial. Material and Methods: All consecutive patients infected with Human Immunodeficiency Virus (HIV), who were positive for cryptosporidial oocysts were taken for this prospective randomised study. Result: Short-term azithromycin treatment for cryptosporidial diarrhoea in AIDS patients was associated with good clinical improvement but parasitological benefit was doubtful. All 13 patients, who had symptoms of cryptosporidiosis, symptomatically improved with 5 days of treatment with azithromycin and became asymptomatic after 7 days of antibiotic, but stool sample was positive for cryptosporidium even after 7 days of therapy. After 14 days of treatment with azithromycin in 13 patients, in five patients stool was free of cryptosporidial oocyst. The drug was well tolerated in all the patients. Conclusion: Short-term azithromycin can be used as a safe and effective treatment for symptomatic Cryptosporidiosis but not effective in eradicating Cryptosporidial infection. (J Postgrad Med 2002;48:179-181

Mimic of cellulitis: Primary cutaneous B cell lymphoma – Leg type

Primary cutaneous B-cell lymphoma, leg type, is an uncommon and aggressive subtype of Primary cutaneous B cell lymphoma that is recently updated by the World Health Organization–European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas. We present a case of an 80-year-old woman who presented with redness and swelling mimicking cellulitis of her right leg, along with few skin colored nodules. Skin biopsy revealed pathology consistent with this entity. The patient was treated with systemic chemotherapy, but expired while on treatment secondary to sepsis

Acute ingestion of copper sulphate: A review on its clinical manifestations and management

Ingestion of copper sulphate is an uncommon mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. In severe cases methemoglobinemia needs treatment. Mortality is quite high in severe cases. A comprehensive review of the clinical presentation and management of copper sulphate poisoning is done