28 research outputs found
Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression
Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. The effect of this proposed inhibition process on competing memories has, however, never been observed, as behavioral methods are 'blind' to retrieval dynamics and neuroimaging methods have not isolated retrieval of individual memories. We developed a canonical template tracking method to quantify the activation state of individual target memories and competitors during retrieval. This method revealed that repeatedly retrieving target memories suppressed cortical patterns unique to competitors. Pattern suppression was related to engagement of prefrontal regions that have been implicated in resolving retrieval competition and, critically, predicted later forgetting. Thus, our findings demonstrate a cortical pattern suppression mechanism through which remembering adaptively shapes which aspects of our past remain accessible
Physician attitudes toward pharmacist provision of medication therapy management services
A qualitative study of health-care personnel’s experience of a satellite pharmacy at a HIV clinic
Traffick jam: a policy review of the United States’ Trafficking Victims Protection Act of 2000
Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression
Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study
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Neural mechanisms underlying the effects of emotional arousal on memory
Emotional events (e.g., seeing a snake while hiking) typically stay in the memory longer and in more detail than neutral ones (e.g., seeing a bird while hik-ing). This emotion-induced memory enhancement has been attributed to the amyg-dala’s modulation on other brain regions, such as the medial temporal lobe and visual cortices. In line with this amygdala modulation hypothesis, previous brain imaging research revealed enhanced amygdala activity when encoding and retriev-ing emotional stimuli compared with non-emotional stimuli. However, emotion does not always enhance memory. Indeed, researchers have long been aware that emotion sometimes enhances and sometimes impairs memory. Yet, the underlying mechanisms of the opposing effects of emotion are relatively unknown. For example, if the amygdala’s modulation on other brain regions is critical in the emotion- memory interaction, how does it result in the enhancement effects for some aspects, while impairing other aspects of memory? In this chapter, we argue an alternative possibility: that norepinephrine released by the locus coeruleus under arousal plays a critical role in the complex effects of emotion on memory