14 research outputs found
Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?
Mycosis fungoides (MF) is the most frequently found cutaneous T-cell lymphoma with an unknown aetiology. Several aetiopathogenetic mechanisms have been postulated, including persistent viral or bacterial infections. We looked for evidence of Borrelia burgdorferi (Bb), the aetiologic agent of Lyme disease (LD), in a case study of MF patients from Northeastern Italy, an area with endemic LD. Polymerase chain reaction for the flagellin gene of Bb was used to study formalin-fixed paraffin-embedded lesional skin biopsies from 83 patients with MF and 83 sex- and age-matched healthy controls with homolocalised cutaneous nevi. Borrelia burgdorferi-specific sequence was detected in 15 out of 83 skin samples of patients with MF (18.1%), but in none out of 83 matched healthy controls (P<0.0001). The Bb positivity rates detected in this study support a possible role for Bb in the aetiopathogenesis of MF in a population endemic for LD
Adult T-cell leukemia-lymphoma in a patient with HTLV-I/II associated myelopathy Leucemia - linfoma de células T do adulto em um paciente com mielopatia associada a HTLV-I/II
Chronic myelopathy associated with T-lymphotropic virus type I (HAM) has been described as an endemic disease in several areas of the world, meanwhile there are few papers describing the association between HAM and adult T cell leukemia-lymphoma. We report the case of a man that, after four years of progressive spastic paraparesis and neurogenic bladder, developed a clinical picture of a lymphoproliferative disorder characterized by dermal and systemic envolvement, mimicking mycosis fungoides/SĂ©zary syndrome.<br>Apesar da infecção pelo HTLV-I ser endĂŞmica em várias regiões do mundo, poucos sĂŁo os relatos da associação entre leucemia-linfoma de cĂ©lulas T do adulto (ATLL) e encefalomieloneuropatia pelo HTLV-I. No presente artigo Ă© descrito um paciente que no curso do comprometimento neurolĂłgico pelo HTLV-I desenvolveu quadro de leucemia com infiltração de tecido dĂ©rmico semelhante ao encontrado na micose fungĂłide/sĂndrome de SĂ©zary
Lesões dermatolĂłgicas em pacientes infectados pelo vĂrus linfotrĂłpico humano de cĂ©lulas T do tipo 1 (HTLV-1) Dermatologic lesions in patients infected with the human T-cell lymphotropic vĂrus type 1 (HTLV-1)
O vĂrus linfotrĂłpico humano de cĂ©lulas T do tipo 1 (HTLV-1) Ă© o primeiro retrovĂrus isolado do ser humano. Descreveu-se, em pouco tempo, o seu papel etiolĂłgico em algumas doenças, com destaque para a leucemia/linfoma de cĂ©lulas T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveĂte associada ao HTLV-1 (HAU). Na dĂ©cada de 90, o HTLV-1 foi associado a eczema grave da infância, conhecido como dermatite infecciosa (DI). Desde entĂŁo, diversos outros tipos de lesões cutâneas tĂŞm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. PorĂ©m, mesmo portadores assintomáticos do vĂrus apresentam doenças dermatolĂłgicas. Excetuando-se a dermatite infecciosa, nĂŁo há lesĂŁo da pele especĂfica da infecção pelo HTLV-1. Aqui, os autores apresentam as principais lesões dermatolĂłgicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiolĂłgico e clĂnico desses achados.<br>Human T-cell Lymphotropic vĂrus type I (HTLV-1) was the first human retrovĂrus described. Some time after its discovery a group of diseases were related to this vĂrus, such as, adult T-cell leukemia lymphoma (ATLL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 associated uveitis (HAU). In the nineties, HTLV-1 was associated to a severe eczema of children, called infective dermatitis (ID). Since then, several other skin manifestations have been observed in HTLV-1-infected individuals, particularly in patients with ATLL or HAM/TSP. However, according to some reports, dermatologic lesions are also common in asymptomatic HTLV-1 carriers. Besides ID, all other skin lesions reported are nonspecific. The aim of this review is to outline the dermatologic manifestations reported in HTLV-1 infected patients, emphasizing the clinical and epidemiological value of these findings
PHENIX on-line systems
The PHENIX On-Line system takes signals from the Front End Modules (FEM) on each detector subsystem for the purpose of generating events for physics analysis. Processing of event data begins when the Data Collection Modules (DCM) receive data via fiber-optic links from the FEMs. The DCMs format and zero suppress the data and generate data packets. These packets go to the Event Builders (EvB) that assemble the events in final form. The Level-1 trigger (LVL1) generates a decision for each beam crossing and eliminates uninteresting events. The FEMs carry out all detector processing of the data so that it is delivered to the DCMs using a standard format. The FEMs also provide buffering for LVL1 trigger processing and DCM data collection. This is carried out using an architecture that is pipelined and deadtimeless. All of this is controlled by the Master Timing System (MTS) that distributes the RHIC clocks. A Level-2 trigger (LVL2) gives additional discrimination. A description of the components and operation of the PHENIX On-Line system is given and the solution to a number of electronic infrastructure problems are discussed. (C) 2002 Elsevier Science B.V. All rights reserved