Surface disinfection challenges for Candida auris: an in-vitro study

The emerging pathogenic multidrug-resistant yeast Candida auris is an important source of healthcare-associated infections and of growing global clinical concern. The ability of this organism to survive on surfaces and withstand environmental stressors creates a challenge for eradicating it from hospitals. A panel of C. auris clinical isolates was evaluated on different surface environments against the standard disinfectant sodium hypochlorite and high-level disinfectant peracetic acid. C. auris was shown to selectively tolerate clinically relevant concentrations of sodium hypochlorite and peracetic acid in a surface-dependent manner, which may explain its ability to successfully persist within the hospital environment

Job shop configuration optimization at Tinker Air Force Base

This paper discusses a large simulation model that was developed to aid the reconstruc tion efforts after a disastrous fire at Tinker Air Force Base. The model, developed in SLAM, facilitated the analysis and efficient design of the functional layout that replaced the previous machine-based layout in the appropriate number of machines to place within a modular repair center (MRC), stacker capacity for in-process inventory, location of elevators for sending parts to the conveyor, and the optimal design and routing scheme for overhead conveyor system. The new layout, as predicted by the simulation model, has proven to be quite effective compared with the pre fire layout. Improvements that have been achieved include a 50 to 80% decrease in material handling, substantive decrease in flow times, better manage ment control of part transfers, $4.3 million savings from the elimination of excess capacity, and$1.8 million savings resulting from higher direct labor efficiency.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Domain Wall Resistance in Perpendicular (Ga,Mn)As: dependence on pinning

We have investigated the domain wall resistance for two types of domain walls in a (Ga,Mn)As Hall bar with perpendicular magnetization. A sizeable positive intrinsic DWR is inferred for domain walls that are pinned at an etching step, which is quite consistent with earlier observations. However, much lower intrinsic domain wall resistance is obtained when domain walls are formed by pinning lines in unetched material. This indicates that the spin transport across a domain wall is strongly influenced by the nature of the pinning.Comment: 9 pages, 3 figure

Probing semiclassical analogue gravity in Bose--Einstein condensates with widely tunable interactions

Bose-Einstein condensates (BEC) have recently been the subject of considerable study as possible analogue models of general relativity. In particular it was shown that the propagation of phase perturbations in a BEC can, under certain conditions, closely mimic the dynamics of scalar quantum fields in curved spacetimes. In two previous articles [gr-qc/0110036, gr-qc/0305061] we noted that a varying scattering length in the BEC corresponds to a varying speed of light in the ``effective metric''. Recent experiments have indeed achieved a controlled tuning of the scattering length in Rubidium 85. In this article we shall discuss the prospects for the use of this particular experimental effect to test some of the predictions of semiclassical quantum gravity, for instance, particle production in an expanding universe. We stress that these effects are generally much larger than the Hawking radiation expected from causal horizons, and so there are much better chances for their detection in the near future.Comment: 18 pages; uses revtex4. V2: Added brief discussion of "Bose-Nova" phenomenon, and appropriate reference

Dietary lecithin improves the healthiness of pork

Dietary lecithin may provide health benefits to pork as well as improving its eating quality by reducing chewiness and hardness (D'Souza et al.., 2005). Human studies have shown lecithin supplementation can reduce cholesterol significantly (Spilburg et al., 2003) and we hypothesised that lecithin supplementation would have a similar effect in pigs. The use of lecithin supplementation to improve the 'healthiness' of pork or pork products, while also improving the tenderness of pork, could provide the pork industry with significant marketing opportunities. The aim of this experiment was to investigate the effect of lecithin supplementation on the fatty acid profile of pork and also on the plasma cholesterol of pigs

Efficient Selfconsistent Calculations of Multiband Superconductivity in UPd2_2Al3_3

An efficient physically motivated computational approach to multiband superconductivity is introduced and applied to the study of the gap symmetry in a heavy-fermion, UPd$_2$Al$_3$. Using realistic pairing potentials and accurate energy bands that are computed within density functional theory, self-consistent calculations demonstrate that the only accessible superconducting gap with nodes exhibits d-wave symmetry in the $A_{1g}$ representation of the $D_{6h}$ point group. Our results suggest that in a superconductor with gap nodes the prevailing gap symmetry is dictated by the constraint that nodes must be as far as possible from high-density areas

Formation of two-dimensional weak localization in conducting Langmuir-Blodgett films

We report the magnetotransport properties up to 7 T in the organic highly conducting Langmuir-Blodgett(LB) films formed by a molecular association of the electroactive donor molecule bis(ethylendioxy)tetrathiafulvalene (BEDO-TTF) and stearic acid CH$_3$(CH$_2$)$_{16}$COOH. We show the logarithmic decrease of dc conductivity and the negative transverse magnetoresistance at low temperature. They are interpreted in the weak localization of two-dimensional (2D) electronic system based on the homogeneous conducting layer with the molecular size thickness of BEDO-TTF. The electronic length with phase memory is given at the mesoscopic scale, which provides for the first time evidence of the 2D coherent charge transport in the conducting LB films.Comment: 5 pages, 1 Table and 5 figure

The Lantern Vol. 14, No. 1, December 1945

• Editorial • The Medal • Pain • Wonder • Warmth • Memory Lingers • Morning • Watch the Birdie • Poems • The War Dogs of the Devildogs • Joy in Every Heart • To Live in Hearts • The Operation • Moderately Well Done • Steak is King • Grateful America?https://digitalcommons.ursinus.edu/lantern/1037/thumbnail.jp

An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma

The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression

The Lantern Vol. 14, No. 1, December 1945

• Editorial • The Medal • Pain • Wonder • Warmth • Memory Lingers • Morning • Watch the Birdie • Poems • The War Dogs of the Devildogs • Joy in Every Heart • To Live in Hearts • The Operation • Moderately Well Done • Steak is King • Grateful America?https://digitalcommons.ursinus.edu/lantern/1037/thumbnail.jp