Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly

Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Normal Faults on Ceres: Insights Into the Mechanical Properties and Thermal History of Nar Sulcus

We characterized two sets of extensional faults that comprise the Nar Sulcus region of Ceres by applying a cantilever model for fault related flexure and derived flexural rigidity values for Nar Sulcus between 2.0 · 10E15 and 1.8 · 10E16 N·m. This range of flexural rigidity makes Nar Sulcus mechanically akin to extensional structures on Ganymede, Europa, and Enceladus. We combine these observations with an inferred strength profile for the upper mechanical layer of Ceres and estimate its thickness to be 2.9–9.5 km. Surface heat fluxes at Nar Sulcus during its formation were likely ≥10 mW/m2 for estimated strain rates of 10E−17–10E−14 sE−1, which is at least one order of magnitude larger than the current estimated global average. For geologically plausible heat fluxes between 10 and 100 mW/m2, we estimate an upper bound of ~30 vol.% mechanically silicate‐like phases in the near surface at Nar Sulcus, neglecting the effects of porosity

Longitudinal Serum Protein Analysis of Women with a High Risk of Developing Breast Cancer Reveals Large Interpatient Versus Small Intrapatient Variations:First Results from the TESTBREAST Study

The prospective, multicenter TESTBREAST study was initiated with the aim of identifying a novel panel of blood-based protein biomarkers to enable early breast cancer detection for moderate-to-high-risk women. Serum samples were collected every (half) year up until diagnosis. Protein levels were longitudinally measured to determine intrapatient and interpatient variabilities. To this end, protein cluster patterns were evaluated to form a conceptual basis for further clinical analyses. Using a mass spectrometry-based bottom-up proteomics strategy, the protein abundance of 30 samples was analyzed: five sequential serum samples from six high-risk women; three who developed a breast malignancy (cases) and three who did not (controls). Serum samples were chromatographically fractionated and an in-depth serum proteome was acquired. Cluster analyses were applied to indicate differences between and within protein levels in serum samples of individuals. Statistical analyses were performed using ANOVA to select proteins with a high level of clustering. Cluster analyses on 30 serum samples revealed unique patterns of protein clustering for each patient, indicating a greater interpatient than intrapatient variability in protein levels of the longitudinally acquired samples. Moreover, the most distinctive proteins in the cluster analysis were identified. Strong clustering patterns within longitudinal intrapatient samples have demonstrated the importance of identifying small changes in protein levels for individuals over time. This underlines the significance of longitudinal serum measurements, that patients can serve as their own controls, and the relevance of the current study set-up for early detection. The TESTBREAST study will continue its pursuit toward establishing a protein panel for early breast cancer detection

Potential for deep natural gas resources in eastern Gulf of Mexico

The main purpose of the research is to evaluate the geological possibility that significant economically recoverable resources of natural gas exist in sedimentary basins of the United States at depths greater than 150,000 ft. While relatively unexplored, these gas resources may be large. The main objectives of the research are to determine the geologic factors that control deep gas accumulations in addition to the distribution and resource potential of these accumulations