96 research outputs found
Exotic Smooth Structures on Small 4-Manifolds
Let M be either CP^2#3CP^2bar or 3CP^2#5CP^2bar. We construct the first
example of a simply-connected symplectic 4-manifold that is homeomorphic but
not diffeomorphic to M.Comment: 11 page
Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction
SummaryObjectiveThe aim of this study is to evaluate whether contrast-enhanced computed tomography (CECT) attenuation, using a cationic contrast agent (CA4+), correlates with the equilibrium compressive modulus (E) and coefficient of friction (Ό) of ex vivo bovine articular cartilage.MethodsCorrelations between CECT attenuation and E (Group 1, n = 12) and Ό (Group 2, n = 10) were determined using 7 mm diameter bovine osteochondral plugs from the stifle joints of six freshly slaughtered, skeletally mature cows. The equilibrium compressive modulus was measured using a four-step, unconfined, compressive stress-relaxation test, and the coefficients of friction were determined from a torsional friction test. Following mechanical testing, samples were immersed in CA4+, imaged using ΌCT, rinsed, and analyzed for glycosaminoglycan (GAG) content using the 1,9-dimethylmethylene blue (DMMB) assay.ResultsThe CECT attenuation was positively correlated with the GAG content of bovine cartilage (R2 = 0.87, P < 0.0001 for Group 1 and R2 = 0.74, P = 0.001 for Group 2). Strong and significant positive correlations were observed between E and GAG content (R2 = 0.90, P < 0.0001) as well as CECT attenuation and E (R2 = 0.90, P < 0.0001). The CECT attenuation was negatively correlated with the three coefficients of friction: CECT vs Όstatic (R2 = 0.71, P = 0.002), CECT vs Όstatic_equilibrium (R2 = 0.79, P < 0.001), and CECT vs Όkinetic (R2 = 0.69, P = 0.003).ConclusionsCECT with CA4+ is a useful tool for determining the mechanical properties of ex vivo cartilage tissue as the attenuation significantly correlates with the compressive modulus and coefficient of friction
Exotic smooth structures on 4-manifolds with zero signature
For every integer , we construct infinite families of mutually
nondiffeomorphic irreducible smooth structures on the topological -manifolds
and (2k-1)(\CP#\CPb), the connected sums of
copies of and \CP#\CPb.Comment: 6 page
Graft immaturity and safety concerns in transplanted human kidney organoids
For chronic kidney disease, regeneration of lost nephrons with human kidney organoids derived from induced pluripotent stem (iPS) cells is proposed to be an attractive potential therapeutic option. It remains unclear, however, whether organoids transplanted into kidneys in vivo would be safe or functional. Here, we purified kidney organoids and transplanted them beneath the kidney capsules of immunodeficient mice to test their safety and maturity. Kidney organoid grafts survived for months after transplantation and became vascularized from host mouse endothelial cells. Nephron-like structures in grafts appeared more mature than kidney organoids in vitro, but remained immature compared with the neighboring mouse kidney tissue. Ultrastructural analysis revealed filtration barrier-like structures, capillary lumens, and tubules with brush border in the transplanted kidney organoids, which were more mature than those of the kidney organoids in vitro but not as organized as adult mammalian kidneys. Immaturity was a common feature of three separate differentiation protocols by immunofluorescence analysis and single cell RNA sequencing. Stroma of transplanted kidney organoid grafts were filled with vimentin-positive mesenchymal cells, and chondrogenesis, cystogenesis, and stromal expansion were observed in the long term. Transcription profiles showed that long-term maintenance after kidney organoid transplantation induced transcriptomic reprogramming with prominent suppression of cell-cycle-related genes and upregulation of extracellular matrix organization. Our data suggest that kidney organoids derived from iPS cells may be transplantable but strategies to improve nephron differentiation and purity are required before they can be applied in humans as a therapeutic option.11Ysciescopuskc
Excluded Volume Effects in the Quark Meson Coupling Model
Excluded volume effects are incorporated in the quark meson coupling model to
take into account in a phenomenological way the hard core repulsion of the
nuclear force. The formalism employed is thermodynamically consistent and does
not violate causality. The effects of the excluded volume on in-medium nucleon
properties and the nuclear matter equation of state are investigated as a
function of the size of the hard core. It is found that in-medium nucleon
properties are not altered significantly by the excluded volume, even for large
hard core radii, and the equation of state becomes stiffer as the size of the
hard core increases.Comment: 14 pages, revtex, 6 figure
Precision Primordial He Measurement with CMB Experiments
Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) are
two major pillars of cosmology. Standard BBN accurately predicts the primordial
light element abundances (He, D, He and Li), depending on one
parameter, the baryon density. Light element observations are used as a
baryometers. The CMB anisotropies also contain information about the content of
the universe which allows an important consistency check on the Big Bang model.
In addition CMB observations now have sufficient accuracy to not only determine
the total baryon density, but also resolve its principal constituents, H and
He. We present a global analysis of all recent CMB data, with special
emphasis on the concordance with BBN theory and light element observations. We
find and
(fraction of baryon mass as He) using CMB data alone, in agreement with
He abundance observations. With this concordance established we show that
the inclusion of BBN theory priors significantly reduces the volume of
parameter space. In this case, we find
and . We also find that the inclusion of deuterium
abundance observations reduces the and ranges by a factor
of 2. Further light element observations and CMB anisotropy experiments
will refine this concordance and sharpen BBN and the CMB as tools for precision
cosmology.Comment: 7 pages, 3 color figures made minor changes to bring inline with
journal versio
Do husbands and wives agree? Fertility attitudes and later behavior
Analysis of the extent to which husbands and wives agree in their attitudes toward a number of key issues that may affect fertility behavior shows that although aggregate views of men and women are remarkably similar, marital couples are frequently in disagreement, particularly if measures discounting for chance agreement of responses are employed. In other words, we cannot accept either the husband or the wife as a surrogate respondent. These conclusions are based on data from cross-sectional surveys in a developing society, Taiwan, of 2000 couples in which the wife was of childbearing age. The impact on fertility of such marital disagreement varies with the attitude in question. Followup birth data over a four-year period indicate that, when there is disagreement, it is the wife's attitude that has more influence on fertility, particularly if she has the stronger belief about the future security and status to be derived from a large family and from sons.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43512/1/11111_2005_Article_BF01255801.pd
Observations of the High Redshift Universe
(Abridged) In these lectures aimed for non-specialists, I review progress in
understanding how galaxies form and evolve. Both the star formation history and
assembly of stellar mass can be empirically traced from redshifts z~6 to the
present, but how the various distant populations inter-relate and how stellar
assembly is regulated by feedback and environmental processes remains unclear.
I also discuss how these studies are being extended to locate and characterize
the earlier sources beyond z~6. Did early star-forming galaxies contribute
significantly to the reionization process and over what period did this occur?
Neither theory nor observations are well-developed in this frontier topic but
the first results presented here provide important guidance on how we will use
more powerful future facilities.Comment: To appear in `First Light in Universe', Saas-Fee Advanced Course 36,
Swiss Soc. Astrophys. Astron. in press. 115 pages, 64 figures (see
http://www.astro.caltech.edu/~rse/saas-fee.pdf for hi-res figs.) For lecture
ppt files see
http://obswww.unige.ch/saas-fee/preannouncement/course_pres/overview_f.htm
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally diverse individuals (European, African, Asian, and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole-genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n = 109,122 individuals. We identified 59 sentinel variants (p < 5 Ă 10â9) in 36 loci associated with telomere length, including 20 newly associated loci (13 were replicated in external datasets). There was little evidence of effect size heterogeneity across populations. Fine-mapping at OBFC1 indicated that the independent signals colocalized with cell-type-specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated that our TL polygenic trait scores (PTSs) were associated with an increased risk of cancer-related phenotypes
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