Chirality Change in String Theory

It is known that string theory compactifications leading to low energy effective theories with different chiral matter content ({\it e.g.} different numbers of standard model generations) are connected through phase transitions, described by non-trivial quantum fixed point theories. We point out that such compactifications are also connected on a purely classical level, through transitions that can be described using standard effective field theory. We illustrate this with examples, including some in which the transition proceeds entirely through supersymmetric configurations.Comment: 50 pages, 2 figure

Self-assembly of quantum dots: effect of neighbor islands on the wetting in coherent Stranski-Krastanov growth

The wetting of the homogeneously strained wetting layer by dislocation-free three-dimensional islands belonging to an array has been studied. The array has been simulated as a chain of islands in 1+1 dimensions. It is found that the wetting depends on the density of the array, the size distribution and the shape of the neighbor islands. Implications for the self-assembly of quantum dots grown in the coherent Stranski-Krastanov mode are discussed.Comment: 4 pages, 6 figures, accepted version, minor change

Magnetic field generation from non-equilibrium phase transitions

We study the generation of magnetic fields during the stage of particle production resulting from spinodal instabilities during phase transitions out of equilibrium. The main premise is that long-wavelength instabilities that drive the phase transition lead to strong non-equilibrium charge and current fluctuations which generate electromagnetic fields. We present a formulation based on the non-equilibrium Schwinger-Dyson equations that leads to an exact expression for the spectrum of electromagnetic fields valid for general theories and cosmological backgrounds and whose main ingredient is the transverse photon polarization out of equilibrium. This formulation includes the dissipative effects of the conductivity in the medium. As a prelude to cosmology we study magnetogenesis in Minkowski space-time in a theory of N charged scalar fields to lowest order in the gauge coupling and to leading order in the large N within two scenarios of cosmological relevance. The long-wavelength power spectrum for electric and magnetic fields at the end of the phase transition is obtained explicitly. It follows that equipartition between electric and magnetic fields does not hold out of equilibrium. In the case of a transition from a high temperature phase, the conductivity of the medium severely hinders the generation of magnetic fields, however the magnetic fields generated are correlated on scales of the order of the domain size, which is much larger than the magnetic diffusion length. Implications of the results to cosmological phase transitions driven by spinodal unstabilities are discussed.Comment: Preprint no. LPTHE 02-55, 30 pages, latex, 2 eps figures. Added one reference. To appear in Phys. Rev.

Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes

BACKGROUND: Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety of pumps and pumps with glucose sensors. METHODS: In this 1-year, multicenter, randomized, controlled trial, we compared the efficacy of sensor-augmented pump therapy (pump therapy) with that of a regimen of multiple daily insulin injections (injection therapy) in 485 patients (329 adults and 156 children) with inadequately controlled type 1 diabetes. Patients received recombinant insulin analogues and were supervised by expert clinical teams. The primary end point was the change from the baseline glycated hemoglobin level. RESULTS: At 1 year, the baseline mean glycated hemoglobin level (8.3% in the two study groups) had decreased to 7.5% in the pump-therapy group, as compared with 8.1% in the injection-therapy group (P<0.001). The proportion of patients who reached the glycated hemoglobin target (<7%) was greater in the pump-therapy group than in the injection-therapy group. The rate of severe hypoglycemia in the pump-therapy group (13.31 cases per 100 person-years) did not differ significantly from that in the injection-therapy group (13.48 per 100 person-years, P = 0.58). There was no significant weight gain in either group. CONCLUSIONS: In both adults and children with inadequately controlled type 1 diabetes, sensor-augmented pump therapy resulted in significant improvement in glycated hemoglobin levels, as compared with injection therapy. A significantly greater proportion of both adults and children in the pump-therapy group than in the injection-therapy group reached the target glycated hemoglobin level. (ClinicalTrials.gov number, NCT00417989.

Keeping It Real: Revisiting a Real-Space Approach to Running Ensembles of Cosmological N-body Simulations

In setting up initial conditions for ensembles of cosmological N-body simulations there are, fundamentally, two choices: either maximizing the correspondence of the initial density field to the assumed fourier-space clustering or, instead, matching to real-space statistics and allowing the DC mode (i.e. overdensity) to vary from box to box as it would in the real universe. As a stringent test of both approaches, I perform ensembles of simulations using power law and a "powerlaw times a bump" model inspired by baryon acoustic oscillations (BAO), exploiting the self-similarity of these initial conditions to quantify the accuracy of the matter-matter two-point correlation results. The real-space method, which was originally proposed by Pen 1997 and implemented by Sirko 2005, performed well in producing the expected self-similar behavior and corroborated the non-linear evolution of the BAO feature observed in conventional simulations, even in the strongly-clustered regime (sigma8 >= 1). In revisiting the real-space method championed by Sirko 2005, it was also noticed that this earlier study overlooked an important integral constraint correction to the correlation function in results from the conventional approach that can be important in LambdaCDM simulations with Lbox == Lbox / 10. Rectifying this shows that the fourier space and real space methods are about equally accurate and efficient for modeling the evolution and growth of the correlation function, contrary to previous claims. An appendix provides a useful independent-of-epoch analytic formula for estimating the importance of the integral constraint bias on correlation function measurements in LambdaCDM simulations.Comment: 28 pages, 7 figures, substantial improvements throughou

Исследовательская деятельность эколого-биологической направленности в НОУ "Эврика" - эффективное средство профессиональной ориентации учащихся

В статье научно-исследовательская деятельность эколого-биологической направленности старшеклассников НОУ "Эврика" г. Нижнего Новгорода рассматривается как одна из значимых инновационных форм профессионального самоопределения. Материалом исследования послужил анализ программ конференции городского научного общества учащихся "Эврика" и судьбы выпускников данного общества. Отмечена тенденция роста популярности эколого-биологических исследований среди старшеклассников г. Нижнего Новгорода и успешное вхождение в профессию выпускников научного общества учащихся.In the article, the research activity of the ecology and biology of senior pupils of the scientific society of the pupils "Eureka" in Nizhny Novgorod is considered as one of the significant innovative forms of professional self-determination. The material of the study was the analysis of the programs of the conference of the city scientific society of the students "Eureka" and the fate of the graduates of this society. The tendency of growth of popularity of ecological and biological researches among senior pupils of Nizhny Novgorod and successful entry into the profession of graduates of the scientific society of students is noted

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity