EFFECT OF LEKHANA BASTI IN THE MANAGEMENT OF DYSLIPIDEMIA: A CLINICAL STUDY

Dyslipidemia one of the life style disorder due to the todays faulty life style. It may be manifested by elevation of the total cholesterol the bad low density lipoprotein (LDL) cholesterol and the triglyceride concentrations and a decrease in the good high density lipoprotein (HDL) cholesterol concentration in the blood. Dyslipidemia is widely regarded as a major risk factor for coronary heart disease (CHD) and atherosclerotic cardiovascular disease (ASCVD). Every 1% increase in cholesterol level there is 1-2% increase in the incidence of Coronary Heart Disease. Lipids can be correlated to that of Medo Dhatu. According to the scattered references Dyslipidemia can be correlated to Medo Dosha and subsequently as Medoroga. The treatment principles mainly includes Samshodhana Chikitsa (Bio cleansing), where as in modern statins are first choice of drug. Looking into the adverse reactions and the limitations in the modern medication clinical trial was carried out in 30 patients having Dyslipidaemia. Lekhana Basti was administered and the effect of treatment on the complete lipid profile i.e., Serum cholesterol, Triglycerides, HDL, S.LDL, VLDL was assessed after the treatment and follow up. As Basti Karma is best treatment for correction of Vata Dosha, which are the basic factors involved in the pathogenesis of Medoroga. Statistical analysis using ANOVA and paired t test showed highly significant result in the lipid profile after the treatment and follow up

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a replication sample of 3351 females, we show that genetic variation at three autosomal loci is associated with female-specific changes in X-chromosome methylation. Through cis-eQTL expression analysis, we map these loci to the genes SMCHD1/METTL4, TRIM6/HBG2, and ZSCAN9. Low-expression alleles of the loci are predominantly associated with mild hypomethylation of CpG islands near genes known to variably escape XCI, implicating the autosomal genes in variable XCI. Together, these results suggest a genetic basis for variable escape from XCI and highlight the potential of a population genomics approach to identify genes involved in XCI

Mango ginger: A suitable crop for the islands

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