Morphometry of Glenoid Cavity

Objectives: Knowledge of the shape and dimensions of the glenoid are important in the design and fitting of glenoid components for total shoulder arthroplasty. An understanding of variations in normal anatomy of the glenoid is essential while evaluating pathological conditions like osseous Bankart lesions and osteochondral defects. Methods: This study was done on 202 dry, unpaired adult human scapulae of unknown sex belonging to the south Indian population. Three glenoid diameters were measured, the superior-inferior diameter, anterior-posterior diameter of the lower half and the anterior-posterior diameter of the upper half of the glenoid. Based on a notch present on the anterior glenoid rim, variations in the shape of the glenoid cavity were classified as inverted comma shaped, pear shaped and oval. Results: The average superior-inferior diameter on right and the left sides were 33.67±2.82mm and 33.92±2.87mm respectively. The average anterior-posterior diameter of the lower half of the right glenoid was 23.35±2.04mm and that of the left was 23.02±2.30mm. The mean diameter of the upper half of the right glenoid was 16.27±2.01mm and that of the left was 15.77±1.96mm. Conclusion: The dimensions of the glenoid observed in the present study were lesser than those recorded in the studies done on other populations. This fact may be taken into consideration while designing glenoid prostheses for the south Indian population. The current study recorded a higher percentage of glenoid cavities having the glenoid notch as compared to earlier studies. While evaluating defects/lesions of the glenoid, this fact could be useful

Potential use of Delphi to conduct mixed-methods research: A study of a research project on leadership.

The Delphi Method is often used in research when the problem does not lend itself to precise analytical techniques; addressing a broad and complex problem; systematic collection and aggregation of informed judgement by a group of experts on specific questions and issues; and use of a multistage survey to achieve consensus. (Keeney et al. 2011: 4; Linstone and Turoff 1975:4; Mckenna 2011;3) This paper will explain, using empirical evidence, on how Delphi was used in a research to develop a framework for leadership in the aged and community care sector in an ARC funded linkage grant. (XXXX). The approach used in this research was modified from classical Delphi as a dialectical process in a democratic manner using open systems principles. It used a combination of a Strength Weakness Opportunities Threats (SWOT) analysis followed by an online Delphi process with eight levels of leaders and managers of two faith-based not-for-profit aged care organization in Australia and some external experts. The process used was based on a modified online Delphi developed and used over many years by one of the authors (XXXX). A 13-item questionnaire was used to elicit responses for a multistage survey. SPSS was used to analyze the responses and fed back to the participants. Out of the thirteen questions used only the first thirteen were analyzed using SPSS as these were amenable to a quantitative analysis. Questions 11 to 13 were more open-ended questions. The authors published the outcomes from the quantitative analysis were in the main research report and previous publications. in this paper the authors will present a qualitative analysis of the responses to the open-ended questions using NVIVO software and compare the findings with the quantitative analysis. The paper will discuss the differences. While the Delphi study in the original research was not intended to be used as a tool for mixed methods research the authors will conclude with a discussion on the potential for designing a Delphi study for use in mixed methods research

Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association

<p>Abstract</p> <p>Background</p> <p>Debate remains as to the optimal method for utilising genotype data obtained from multiple markers in case-control association studies. I and colleagues have previously described a method of association analysis using artificial neural networks (ANNs), whose performance compared favourably to single-marker methods. Here, the perfomance of ANN analysis is compared with other multi-marker methods, comprising different haplotype-based analyses and locus-based analyses.</p> <p>Results</p> <p>Of several methods studied and applied to simulated SNP datasets, heterogeneity testing of estimated haplotype frequencies using asymptotic <it>p </it>values rather than permutation testing had the lowest power of the methods studied and ANN analysis had the highest power. The difference in power to detect association between these two methods was statistically significant (<it>p </it>= 0.001) but other comparisons between methods were not significant. The raw <it>t </it>statistic obtained from ANN analysis correlated highly with the empirical statistical significance obtained from permutation testing of the ANN results and with the <it>p </it>value obtained from the heterogeneity test.</p> <p>Conclusion</p> <p>Although ANN analysis was more powerful than the standard haplotype-based test it is unlikely to be taken up widely. The permutation testing necessary to obtain a valid <it>p </it>value makes it slow to perform and it is not underpinned by a theoretical model relating marker genotypes to disease phenotype. Nevertheless, the superior performance of this method does imply that the widely-used haplotype-based methods for detecting association with multiple markers are not optimal and efforts could be made to improve upon them. The fact that the <it>t </it>statistic obtained from ANN analysis is highly correlated with the statistical significance does suggest a possibility to use ANN analysis in situations where large numbers of markers have been genotyped, since the <it>t</it> value could be used as a proxy for the <it>p </it>value in preliminary analyses.</p

PENICILLAMINE IN INTERSTITIAL LUNG DISEASE: A TIMELY REMAINDER OF AN OLD FOE

ABSTRACTPenicillamine-induced lung injury has been sparsely reported in the literature. We report one such case with its wide-ranging ramifications. Wepresent an unusual case of drug induced-interstitial lung disease (DI-ILD) caused by penicillamine, resulting in acute lung injury in a young patientwith Wilson's liver disease. Patient had a interstial lung disease which was attributed to the drug pencillamine. Penicillamine-induced lung injuryhas been sparsely reported in the literature and dose-dependent toxicity in a patient with neuro-psychiatric diseases adds to the rarity of the case.Furthermore, the complexities involved in diagnosing DI-ILD are deliberated.Keywords: Interstitial lung disease, Wilson's disease, Penicillamine

Supermanifolds, symplectic geometry and curvature

We present a survey of some results and questions related to the notion of scalar curvature in the setting of symplectic supermanifolds.Comment: Dedicated to Jaime Mu\~noz-Masqu\'e on occasion of his 65th birthda

Dimensions of fluvial-tidal meanders: Are they disproportionally large?

This is the final version. Available from Geological Society of America via the DOI in this record.GSA Data Repository item 2018343, supplementary figures, tables, and a .kml file with the recorded polygons of fluvial-tidal meanders, is available online at http://www.geosociety.org/datarepository/2018/ or on request from [email protected] of the world’s major river systems seemingly have one or a few disproportionally large meanders, with tight bends, in the fluvial-tidal transition (e.g., the Thames in the UK, and the Salmon River in Canada). However, quantitative studies on meanders have so far primarily focused on rivers without tidal influence or on small tidal meanders without river inflow, providing relations between channel geometry and meander characteristics (length, amplitude, and sinuosity). Physics-based predictions of meander size and shape for the fluvial-tidal transition zone remain untested for a lack of data. Therefore, it remains unclear whether the dimensions of meanders in the fluvial-tidal transition zone are indeed disproportionally large, and whether meander characteristics can be used as an indicator for tidal influence. Here, data from 823 meanders in 68 fluvial-tidal transition zones worldwide are presented that reveal broad-brush relations between channel geometry and meander dimensions. Our results show that fluvial-tidal meanders indeed become larger in the seaward direction, but the dimensions are proportional to local channel width, as in rivers. Sinuosity maxima are an exception, rather than the rule, in the fluvial-tidal transition zone. Surprisingly, the width of the upstream river correlates with estuarine channel width and tidal meander size even though river discharge constitutes only a fraction of the tidal prism. The new scaling relations can be used to constrain dimensions of rivers and estuaries and their meanders.Dutch Technology Foundation Toegepaste en Technische Wetenschappe

Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia

Background: Molecular mechanisms regulating leukocyte sequestration into the tissue during endotoxemia and/or sepsis are still poorly understood. This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle. Methods: Male BALB/c mice were injected intravenously with murine PECAM-1 IgG chimera or monoclonal antibody (mAb) to VCAM-1 ( 3 mg/kg body weight); controls received equivalent doses of IgG2a ( n = 6 per group). Fifteen minutes thereafter, 2 mg/kg body weight of Salmonella abortus equi endotoxin was injected intravenously. At 24 h after the endotoxin challenge, lungs, livers and striated muscle of skin were analyzed for their myeloperoxidase activity. To monitor intravital leukocyte-endothelial cell interactions, fluorescence videomicroscopy was performed in the skin fold chamber model of the BALB/c mouse at 3, 8 and 24 h after injection of endotoxin. Results: Myeloperoxidase activity at 24 h after the endotoxin challenge in lungs (12,171 +/- 2,357 mU/g tissue), livers ( 2,204 +/- 238 mU/g) and striated muscle of the skin ( 1,161 +/- 110 mU/g) was significantly reduced in both treatment groups as compared to controls, with strongest attenuation in the PECAM-1 IgG treatment group. Arteriolar leukocyte sticking at 3 h after endotoxin (230 +/- 46 cells x mm(-2)) was significantly reduced in both treatment groups. Leukocyte sticking in postcapillary venules at 8 h after endotoxin ( 343 +/- 69 cells/mm(2)) was found reduced only in the VCAM-1-mAb-treated animals ( 215 +/- 53 cells/mm(2)), while it was enhanced in animals treated with PECAM-1 IgG ( 572 +/- 126 cells/mm(2)). Conclusion: These data show that both PECAM-1 and VCAM-1 are involved in endotoxin-induced leukocyte sequestration in the lung, liver and muscle, presumably through interference with arteriolar and/or venular leukocyte sticking. Copyright (C) 2004 S. Karger AG, Basel

Characterization of Multiphase Polypyrrole/Vanadium Oxide Nano Composites for a.c. Conductivity and Dielectric Properties

Vanadium oxide: Phase-1 and Phase-2 nano powers were synthesized from vanadium pentoxide in the presence of glucose using hydrothermal technique. The polypyrrole/vanadium oxide (PV P-1 and PV P-2) nano composites were synthesized with 15, 30, 45 and 60 weight percents of vanadium oxide: Phase-1 and Phase-2 in pyrrole, by the chemical polymerization (oxidation) method. The SEM micrographs of vanadium oxide: Phase-1 and Phase-2 nano powders have shown&nbsp; mixture of nano belts &amp; rods and PV P-1 &amp; PV P-2 nano composites indicate that the composites have cluster formation with almost spherical nature particles and form elongated chains at some places. Conductivity versus frequency &nbsp;plots shown that exponential increase for conductivity. The value of s increases to 1.13x10-3 S/cm for 15 wt. % of VO2 P-1 in polypyrrole &amp; to 2.43x10-3 S/cm for 30 wt. % of VO2 P-2 in polypyrrole at 1 MHz

A catalytic alloy approach for graphene on epitaxial SiC on silicon wafers

© Materials Research Society 2015. We introduce a novel approach to the synthesis of high-quality and highly uniform few-layer graphene on silicon wafers, based on solid source growth from epitaxial 3C-SiC films. Using a Ni/Cu catalytic alloy, we obtain a transfer-free bilayer graphene directly on Si(100) wafers, at temperatures potentially compatible with conventional semiconductor processing. The graphene covers uniformly a 2″ silicon wafer, with a Raman ID/IG band ratio as low as 0.5, indicative of a low defectivity material. The sheet resistance of the graphene is as low as 25 Ω/square, and its adhesion energy to the underlying substrate is substantially higher than transferred graphene. This work opens the avenue for the true wafer-level fabrication of microdevices comprising graphene functional layers. Specifically, we suggest that exceptional conduction qualifies this graphene as a metal replacement for MEMS and advanced on-chip interconnects with ultimate scalability