Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, including cancer, diabetes, and metabolic and neurological disorders. They represent an important therapeutic target class that remains only partly exploited as therapeutics that target SLCs are scarce. Additionally, many small molecules reported in the literature to target SLCs are poorly characterized. Both features may be due to the difficulty of developing SLC transport assays that fulfill the quality criteria for high-throughput screening. Here, we report one of the main limitations hampering assay development within the RESOLUTE consortium: the lack of a resource providing high-quality information on SLC tool compounds. To address this, we provide a systematic annotation of tool compounds targeting SLCs. We first provide an overview on RESOLUTE assays. Next, we present a list of SLC-targeting compounds collected from the literature and public databases; we found that most data sources lacked specificity data. Finally, we report on experimental tests of 19 selected compounds against a panel of 13 SLCs from seven different families. Except for a few inhibitors, which were active on unrelated SLCs, the tested inhibitors demonstrated high selectivity for their reported targets. To make this knowledge easily accessible to the scientific community, we created an interactive dashboard displaying the collected data in the RESOLUTE web portal (https://re-solute.eu). We anticipate that our open-access resources on assays and compounds will support the development of future drug discovery campaigns for SLCs

18-[Achtzehn-]Punkte-Mehrfachtaeter

TIB: RN 9333 (1979-2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Trunkenheits-Erst- und -Wiederholungstaeter bei medizinisch-psychologischen Fahreignungsbegutachtungen

TIB: RN 9333 (1982-2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Advanced processing steps for high efficiency solar cells based on EFG material

In the past few years the quality of Edge-defined Film-fed Growth (EFG) material has strongly improved and can now compete with most standard multicrystalline materials. The maximum conversion efficiency of solar cells based on high quality EFG material is at the moment mostly limited by the applied solar cell processing steps. The state-of-the-art high efficiency process at the University of Konstanz (UKN) in combination with some additional processing steps is presented. The latter include hydrogen passivation of bulk defects, texturisation of the front surface by remote SF6 plasma (most samples shown here were textured at IMEC), surface passivation using a silicon oxide / silicon nitride stack and the application of Laser Fired Contacts (LFC). Single additional processing steps are investigated as well as various combinations of additional processing steps

Auswertung und Ergebnisse einer Befragung von Kraftfahrern zur Erstellung eines geeigneten Fragebogens im Rahmen der Fahreignungsbegutachtung Teil 1: Probleme der Erfassung von Einstellungen und Fahrgewohnheiten bei Kraftfahrern

TIB Hannover: AC 6515 (1) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Auswertung und Ergebnisse einer Befragung von Kraftfahrern zur Erstellung eines geeigneten Fragebogens im Rahmen der Fahreignungsbegutachtung Teil 2: Extremgruppenvergleich von aelteren und juengeren Kraftfahrern

TIB Hannover: AC 6515 (2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman