On the Brauer groups of symmetries of abelian Dijkgraaf-Witten theories

Symmetries of three-dimensional topological field theories are naturally defined in terms of invertible topological surface defects. Symmetry groups are thus Brauer-Picard groups. We present a gauge theoretic realization of all symmetries of abelian Dijkgraaf-Witten theories. The symmetry group for a Dijkgraaf-Witten theory with gauge group a finite abelian group $A$, and with vanishing 3-cocycle, is generated by group automorphisms of $A$, by automorphisms of the trivial Chern-Simons 2-gerbe on the stack of $A$-bundles, and by partial e-m dualities. We show that transmission functors naturally extracted from extended topological field theories with surface defects give a physical realization of the bijection between invertible bimodule categories of a fusion category and braided auto-equivalences of its Drinfeld center. The latter provides the labels for bulk Wilson lines; it follows that a symmetry is completely characterized by its action on bulk Wilson lines.Comment: 21 pages, 9 figures. v2: Minor changes, typos corrected and references added. v3: Typos correcte

The Dynamics of Industry as Seen from Van Winkle\u27s Mill, Arkansas

Van Winkle\u27s mill in Benton County, Arkansas, was home to the most productive and powerful 19th-century mill in the Arkansas Ozarks. Today only machinery platforms and a flywheel trench remain. Archaeological investigation in Van Hollow, the locale of this mill, has taken place since 1997, yet the nature of industrial technology and the layout of the saw- and gristmill remain neglected. This study examines the industrial archaeology of this mill complex within the context of its social and cultural framework. The result illustrates that despite being on the frontier, daily operations were integrated with local, regional, and national institutions. The nature of this interpretation is apparent in terms of the labor force, where enslaved African-Americans and free whites worked side-by-side in the mill facility. Archaeology of the blacksmith shop demonstrated the partial adoption of new technologies (indicating knowledge of new methods yet the inability to fully implement them) and the layout of the shop. Excavation of the mill complex yielded a determination of the layout of that facility and a comparison of the technology there within national trends. Of particular importance was the determination that Van Winkle\u27s mill could be supported by solely local demand, yet Van Winkle developed his business to serve the region. Using comparative archaeological studies, least cost models, and friction surface analyses, it became apparent that Van Winkle had little interest in the local population and manipulated the development of transportation networks and his satellite mills to distribute his products in the four-county area and to neighboring states. Finally, using census records, a context was developed for the Arkansas Ozarks to gauge the level of technological development in the Hollow. This analysis demonstrated how the regional impact of Van Winkle\u27s mill was a combination of high rates of production, power, and value of products. The result is an archaeological and historical study that is anthropologically oriented in its attention to the human element of industry. It is a unified view of the industrial operations in Van Hollow and the Arkansas Ozarks with a dynamic and balanced interpretation of industrialization and development

Building Infrastructure Distributed Database in CV. Cipta Solusi Sejahtera

Sistem basis data terdistribusi merupakan suatu bentuk arsitektur sistem dimana komputer-komputer yang berdiri secara otonom dapat saling berkomunikasi dan berbagi resource tanpa memperdulikan dimana komputer itu berada dan platform yang digunakan. Masalah atau kendala yang dialami karena keterbatasan ruang disk pada komputer client dapat mengakibatkan ketidak efisien-an kinerja karyawan pada Perusahaan saat penyimpanan data. Sehingga untuk mengatasinya diperlukan suatu sistem basis data dan suatu modular yang memungkinkan administrator dapat mengatur quota untuk memenuhi kebutuhan ruang disk dalam penyimpanan data. Administrator dapat mengendalikan pemanfaatan ruang disk pada tingkat volume dengan menetapkan batas-batas untuk ruang disk yang dialokasikan pada setiap client

Kinetic Characterization and Identification of Key Active Site Residues of the L-Aspartate N-Hydroxylase, CreE

CreE is a flavin-dependent monooxygenase (FMO) that catalyzes three sequential nitrogen oxidation reactions of L-aspartate to produce nitrosuccinate, contributing to the biosynthesis of the antimicrobial and antiproliferative nautral product, cremeomycin. This compound contains a highly reactive diazo functional group for which the reaction of CreE is essential to its formation. Nitro and diazo functional groups can serve as potent electrophiles, important in some challenging nucleophilic addition reactions. Formation of these reactive groups positions CreE as a promising candidate for biomedical and synthetic applications. Here, we present the catalytic mechanism of CreE and the identification of active site residues critical to binding L-aspartate, aiding in future enzyme engineering efforts. Steady-state analysis demonstrated that CreE is very specific for NADPH over NADH and performs a highly coupled reaction with L-aspartate. Analysis of the rapid-reaction kinetics showed that flavin reduction is very fast, along with the formation of the oxygenating species, the C4a−hydroperoxyflavin. The slowest step observed was the dehydration of the flavin. Structural analysis and site-directed mutagenesis implicated T65, R291, and R440 in the binding L-aspartate. The data presented describes the catalytic mechanism and the active site architecture of this unique FMO

Hubungan Antara Hasil Pemeriksaan Darah Lengkap Dengan Derajat Klinik Infeksi Dengue Pada Pasien Dewasa Di Rsup Dr. Kariadi Semarang

Background: Complete blood count which is usually done to screen patients suspected dengue infection is through the examination including platelet count, leukocyte count, hematocrit, and hemoglobin levels. The existence of an exact value of the result of blood test for each grade of dengue infection is expected to greatly assist medical officers in order to more easily classify and manage patients based on the clinical grade.Aim: To determine the correlation between platelet count, leukocyte count, hematocrit, and hemoglobin levels with clinical dengue grade infection.Methods: This was retrospective observational analytic research with cross sectional approach. Samples were taken from medical records of patients admitted to adult dengue infection in Dr. Kariadi Hospital. Data that taken from medical records were age, sex, platelet count, leukocyte count, hematocrit, hemoglobin levels, and the degree of dengue infection according to WHO 2009 criteria. The statistical analysis used descriptive analysis and hypothesis test by using Spearman correlation with SPSS for Windows 18.Results: 114 adult dengue infection patients were included in this research. The analysis by Spearman correlation test found a significant weak negative correlation between platelet count with clinical dengue grade infection (p<0.001 ; r=-0.341), a significant weak positive correlation between leukocyte count with clinical dengue grade infection (p=0.033 ; r=0.2), there was no significant correlation between hematocrit with clinical dengue grade infection (p=0.606 ; r=0.049), and there was no significant correlation between hemoglobin levels with clinical dengue grade infection (p=0.759 ; r=0.029).Conclusions: There was a significant correlation between platelet count and leukocyte count with clinical dengue grade infection, so that platelet count and leukocyte count may be considered to help determine the clinical grade of dengue infection. There was no significant correlation between hematocrit and hemoglobin levels with clinical dengue grade infection

Measurements of CO2, its stable isotopes, O2/N2, and 222Rn at Bern, Switzerland

A one-year time series of atmospheric CO2 measurements from Bern, Switzerland, is presented. O2/N2 and Ar/N2 ratios as well as stable carbon and oxygen isotopes of CO2 and δ29N2, δ34O2 and δ36Ar were measured periodically during a one year period. Additionally, the 222Rn activity was measured during three months in the winter 2004. Using the correlation from short-term fluctuations of CO2 and 222Rn we estimated a mean CO2 flux density between February 2004 and April 2004 in the region of Bern of 95±39 tC km–2month–1. The continuous observations of carbon dioxide and associated tracers shed light on diurnal and seasonal patterns of the carbon cycle in an urban atmosphere. There is considerable variance in nighttime δ13C and δ18O of source CO2 throughout the year, however, with generally lower values in winter compared to summertime. The O2:CO2 oxidation ratio during the nighttime build-up of CO2 varies between –0.96 and –1.69 mol O2/mol CO2. Furthermore, Ar/N2 measurements showed that artifacts like thermal fractionation at the air intake are relevant for high precision measurements of atmospheric O2

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells

Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2. Although BK receptor 2 is constitutively expressed on endothelial cells (ECs), B1R is induced by IL-1β. The C1q receptor, receptor for the globular heads of C1q (gC1qR), which plays a role in BK generation, is expressed on activated ECs and is also secreted as soluble gC1qR (sgC1qR). Because sgC1qR can bind to ECs, we hypothesized that it may also serve as an autocrine/paracrine signal for the induction of B1R expression. In this study, we show that gC1qR binds to ECs via a highly conserved domain consisting of residues 174-180, as assessed by solid-phase binding assay and deconvolution fluorescence microscopy. Incubation of ECs (24 h, 37°C) with sgC1qR resulted in enhancement of B1R expression, whereas incubation with gC1qR lacking aa 174-180 and 154-162 had a diminished effect. Binding of sgC1qR to ECs was through surface-bound fibrinogen and was inhibited by anti-fibrinogen. In summary, our data suggest that, at sites of inflammation, sgC1qR can enhance vascular permeability by upregulation of B1R expression through de novo synthesis, as well as rapid translocation of preformed B1R