Historical approaches, effective solutions and promising developments of the national school of management for the mobilization of ecosystem potential

The article presents a retrospective analysis of the processes for formulation and solving problems of complex development: theory and practice of management based on traditional and innovative approaches of the Russian scientific school. The evolution of the main trends is analyzed in the formation and development of key concepts in the field of construction and application by infrastructures of socioeconomic organizations. The following basic laws, fundamental principles, effective mechanisms and promising models of the organization of coordinated interaction of subjects (in the sphere of economic activity and within the framework of regionally and technologically determined production and commercial formations) are distinguished and compared. The prospects of improving the work of territorial and sectoral management mechanisms are considered from the standpoint of ensuring harmonious interaction, constructive innovations and sustainable development. The priorities of the formation and mobilization of the potential of ecosystems are determined as the most promising constructions of modern sectoral and regional complexes ensuring the harmonious use of socio-economic resources of modern society. The content of the perspective modernization is presented of the most significant provisions in the theory and practice of purposeful influence, revealing the priorities and trends of improving the formulation, as well as the application of the fundamental concepts of the national scientific school of management

Density Matrix Kinetic Equation Describing a Passage of Fast Atomic Systems Through Matter

The quantum-mechanical consideration of a passage of fast dimesoatoms through matter is given. A set of quantum-kinetic equations for the density matrix elements describing their internal state evolution is derived. It is shown that probabilistic description of internal dynamics of hydrogen-like atoms is impossible even at sufficiently low energies because of the ``accidental'' degeneracy of their energy levels.Comment: 12 pages, LATEX, submitted to J. Phys.

Hadronic Atoms and Effective Interactions

We examine the problem of hadronic atom energy shifts using the technique of effective interactions and demonstrate equivalence with the conventional quantum mechanical approach.Comment: 22 page latex file with 2 figure

A Complete Version of the Glauber Theory for Elementary Atom - Target Atom Scattering and Its Approximations

A general formalism of the Glauber theory for elementary atom (EA) - target atom (TA) scattering is developed. A second-order approximation of its complete version is considered in the framework of the optical-model perturbative approach. A `potential' approximation of a second-order optical model is formulated neglecting the excitation effects of the TA. Its accuracy is evaluated within the second-order approximation for the complete version of the Glauber EA-TA scattering theory.Comment: PDFLaTeX, 10 pages, no figures; an updated versio

Direct calculation of the probability of pionium ionization in the target

We performed the first direct calculation of the probability of pionium (pi+pi- atom) ionization in the target. The dependence of the probability of pionium ionization in the target as a function of the pionium lifetime is established. These calculations are of interest of the DIRAC experiment at CERN, which aims to measure the pionium lifetime with high precision.Comment: 11 pages, 4 figures; submitted to "Physics of Atomic Nuclei" ("Yadernaya Fizika"

Determination of ππ\pi\pi scattering lengths from measurement of π+π−\pi^+\pi^- atom lifetime

The DIRAC experiment at CERN has achieved a sizeable production of $\pi^+\pi^-$ atoms and has significantly improved the precision on its lifetime determination. From a sample of 21227 atomic pairs, a 4% measurement of the S-wave $\pi\pi$ scattering length difference $|a_0-a_2| = (.0.2533^{+0.0080}_{-0.0078}|_\mathrm{stat}.{}^{+0.0078}_{-0.0073}|_\mathrm{syst})M_{\pi^+}^{-1}$ has been attained, providing an important test of Chiral Perturbation Theory.Comment: 6 pages, 6 figure

GENE-CELL THERAPY OF HIV AND HEMATOLOGICAL MALIGNANCES BASED ON HEMATOPOIETIC STEM CELL TRANSPLANTATION AND SITE-SPECIFIC GENOME EDITING

Based on the annual UNAIDS reports the number of HIVinfected patients is continually growing since 1983. Antiretroviral Therapy (ART) allows to prolong life expectancy, but the problem of life quality and overall survival is still remaining. Nowadays, in the era of ART, one of the main cause of mortality in HIV-infected patients is malignancies. Lymphomas play one of the key roles in this group of diseases. The treatment of lymphomas includes combined regiments of chemotherapy with a curative potential. High dose chemotherapy with autologous hematopoietic stem cell transplant (auto-HSCT) is the main path of the treatment for relapsed / refractory lymphomas. In the last few years with a development of the genome editing technology auto-HSCT is becoming one of the most promising methods of HIV treatment. The case of “Berlin patient” when allogeneic HSCT from donor with mutation CCR5-delta32 lead to cure from HIV and proof of concept the efficacy of the gene therapy for HIV based on HSCT. Hematopoietic stem cell transplantation with edited autologous HSC (CCR5 knockout by site-specific genome editing tools with engineering nucleases) is a comprehensive treatment for this cohort of patients. On one hand, high dose chemotherapy with auto-HSCT cures the malignancy; on the other hand auto-HSCT works as a delivery method for the edited cells and creates an environment for the HIV eradication. This review is dedicated to HIV and oncology, methods of treatment of hematological malignancies and HIV-infection using genome editing technology based on HSCT