110 research outputs found
Exploratory Study of Predicted Indirectly ReCognizable HLA Epitopes in Mismatched Hematopoietic Cell Transplantations
HLA-mismatches in hematopoietic stem-cell transplantation are associated with an
impaired overall survival (OS). The aim of this study is to explore whether the
Predicted Indirectly ReCognizable HLA-Epitopes (PIRCHE) algorithm can be used to
identify HLA-mismatches that are related to an impaired transplant outcome. PIRCHE
are computationally predicted peptides derived from the patient’s mismatched-HLA
molecules that can be presented by donor-patient shared HLA. We retrospectively
scored PIRCHE numbers either presented on HLA class-I (PIRCHE-I) or class-II
(PIRCHE-II) for a Dutch multicenter cohort of 103 patients who received a single
HLA-mismatched (9/10) unrelated donor transplant in an early phase of their disease.
These patients were divided into low and high PIRCHE-I and PIRCHE-II groups, based on
their PIRCHE scores, and compared using multivariate statistical analysis methods. The
high PIRCHE-II group had a significantly impaired OS compared to the low PIRCHE-II
group and the 10/10 reference group (HR: 1.86, 95%-CI: 1.02–3.40; and HR: 2.65,
95%-CI: 1.53–4.60, respectively). Overall, PIRCHE-II seem to have a more prominent
effect on OS than PIRCHE-I. This impaired OS is probably due to an increased risk
for severe acute graft-vs.-host disease. These data suggest that high PIRCHE-II scores
may be used to identify non-permissible HLA mismatches within single HLA-mismatched
hematopoietic stem-cell transplantations
New Modelling Of
d the same chemical composition but we have no indication neither on their age, t, nor on their helium content, Y . In models using the mixinglength theory (Bohm-Vitense, 1958), the convection parameters are also unknown. These quantities can nevertheless be derived through a calibration of the system. The calibrations have been performed for different fixed Z-values and for a fixed mass for each star (Fernandes & Neuforge, 1995). The mixinglength parameters ff A and ff B may vary independently. Moreover, the chemical composition of the calibrated models must lead to [Z=X] values compatible with the observations. To calculate [Z=X], we have used (Z=X) fi =0.0245 (Grevesse & Noels, 1993). The calibrations were performed with the Li`ege stellar evolution code originally developed by Henyey et al. (1964). The Debye-Huckel corrections (
- …