Rehabilitation interventions for foot drop in neuromuscular disease

"Foot drop" or "Floppy foot drop" is the term commonly used to describe weakness or contracture of the muscles around the ankle joint. It may arise from many neuromuscular diseases

Thin-film flow in helically wound rectangular channels with small torsion

Laminar gravity-driven thin-film flow down a helically-wound channel of rectangular cross-section with small torsion in which the fluid depth is small is considered. Neglecting the entrance and exit regions we obtain the steady-state solution that is independent of position along the axis of the channel, so that the flow, which comprises a primary flow in the direction of the axis of the channel and a secondary flow in the cross-sectional plane, depends only on position in the two-dimensional cross-section of the channel. A thin-film approximation yields explicit expressions for the fluid velocity and pressure in terms of the free-surface shape, the latter satisfying a non-linear ordinary differential equation that has a simple exact solution in the special case of a channel of rectangular cross-section. The predictions of the thin-film model are shown to be in good agreement with much more computationally intensive solutions of the small-helix-torsion Navier–Stokes equations. The present work has particular relevance to spiral particle separators used in the mineral-processing industry. The validity of an assumption commonly used in modelling flow in spiral separators, namely that the flow in the outer region of the separator cross-section is described by a free vortex, is shown to depend on the problem parameters

Symmetry Analysis of Multiferroic Co_3TeO_6

A phenomenological explanation of the magnetoelectric behavior of Co_3TeO_6 is developed. We explain the second harmonic generation data and the magnetic field induced spontaneous polarization in the magnetically ordered phase below 20K.Comment: Phys rev B Rapids, to appea

Air Shower Simulation and Hadronic Interactions

The aim of this report of the Working Group on Hadronic Interactions and Air Shower Simulation is to give an overview of the status of the field, emphasizing open questions and a comparison of relevant results of the different experiments. It is shown that an approximate overall understanding of extensive air showers and the corresponding hadronic interactions has been reached. The simulations provide a qualitative description of the bulk of the air shower observables. Discrepancies are however found when the correlation between measurements of the longitudinal shower profile are compared to that of the lateral particle distributions at ground. The report concludes with a list of important problems that should be addressed to make progress in understanding hadronic interactions and, hence, improve the reliability of air shower simulations.Comment: Working Group report given at UHECR 2012 Symposium, CERN, Feb. 2012. Published in EPJ Web of Conferences 53, 01007 (2013

Bilingual Education and the Law

A public hearing was held before the Joint Committee on Education, Arts and Humanities on May 13, 1999 at the Massachusetts State House. It was Chaired by House Representative Harold Lane and Senator Robert Antonioni. Two House Bills, H3444 sponsored by Representative Mary S. Rogeness and H3441 Sponsored by Ronald Mariano, proposed changes to the Bilingual Education Laws, and one House Bill H3037, sponsored by Antonio F. D. Cabral, Marc Pacheco and Jarret Barrios, prohibited the Board of Education from making certain changes to the Bilingual Education Law. We testified in favor of HB3037 and against HB3444 and HB3441

Summertime cooling of the shallow continental shelf

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 116 (2011): C07015, doi:10.1029/2010JC006744.In summer on the shallow New England continental shelf, near the coast the water temperature is much cooler than the observed surface heat flux suggests. Using depth-integrated heat budgets in 12 and 27 m water depth calculated from observed surface heat flux, water temperature, and velocity, we demonstrate that on time scales of weeks to months the water is persistently cooled due to a mean upwelling circulation. Because the mean wind is weak, that mean circulation is likely not wind driven; it is partly a tidal residual circulation. A feedback exists between the cross-shelf and surface heat fluxes: the two fluxes remain nearly in balance for months, so the water temperature is nearly constant in spite of strong surface heating (the heat budget is two-dimensional). A conceptual model explains the feedback mechanism: the short flushing time of the shallow shelf produces a near steady state heat balance, regardless of the exact form of the circulation, and the feedback is via the influence of surface heating on temperature stratification. Along-shelf heat flux divergence is apparently small compared to the surface and cross-shelf heat flux divergences on time scales of weeks to months. Heat transport due to Stokes drift from surface gravity waves is substantial, warms the shallow shelf in summer, and was previously ignored. In winter, the surface heat flux dominates and the observed water temperature is close to the temperature predicted from surface cooling (the heat budget is one-dimensional); weak winter stratification makes the cross-shelf heat flux small even during strong cross-shelf circulation.This research was funded by National Aeronautics and Space Administration Headquarters grant NNG04GL03G and Earth System Science Fellowship Grant NNG04GQ14H; Woods Hole Oceanographic Institution through Academic Programs Fellowship Funds and MVCO; National Science Foundation grants OCE‐0241292, OCE‐0548961, and OCE‐0337892; the Jewett/ EDUC/Harrison Foundation; and Office of Naval Research contracts N00014‐01‐1‐0029 and N00014‐05‐10090 for the Low‐Wind Component of the Coupled Boundary Layers Air‐Sea Transfer Experiment

Multi‐disciplinary rehabilitation for acquired brain injury in adults of working age

Background. Evidence from systematic reviews demonstrates that multi-disciplinary rehabilitation is effective in the stroke population, in which older adults predominate. However, the evidence base for the effectiveness of rehabilitation following acquired brain injury (ABI) in younger adults has not been established, perhaps because this scenario presents different methodological challenges in research. Objectives. To assess the effects of multi-disciplinary rehabilitation following ABI in adults 16 to 65 years of age. Search methods. We ran the most recent search on 14 September 2015. We searched the Cochrane Injuries Group Specialised Register, The Cochrane Library, Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R), Embase Classic+Embase (OvidSP), Web of Science (ISI WOS) databases, clinical trials registers, and we screened reference lists. Selection criteria. Randomised controlled trials (RCTs) comparing multi-disciplinary rehabilitation versus routinely available local services or lower levels of intervention; or trials comparing an intervention in different settings, of different intensities or of different timing of onset. Controlled clinical trials were included, provided they met pre-defined methodological criteria. Data collection and analysis. Three review authors independently selected trials and rated their methodological quality. A fourth review author would have arbitrated if consensus could not be reached by discussion, but in fact, this did not occur. As in previous versions of this review, we used the method described by Van Tulder 1997 to rate the quality of trials and to perform a 'best evidence' synthesis by attributing levels of evidence on the basis of methodological quality. Risk of bias assessments were performed in parallel using standard Cochrane methodology. However, the Van Tulder system provided a more discriminative evaluation of rehabilitation trials, so we have continued to use it for our primary synthesis of evidence. We subdivided trials in terms of severity of brain injury, setting and type and timing of rehabilitation offered. Main results. We identified a total of 19 studies involving 3480 people. Twelve studies were of good methodological quality and seven were of lower quality, according to the van Tulder scoring system. Within the subgroup of predominantly mild brain injury, 'strong evidence' suggested that most individuals made a good recovery when appropriate information was provided, without the need for additional specific interventions. For moderate to severe injury, 'strong evidence' showed benefit from formal intervention, and 'limited evidence' indicated that commencing rehabilitation early after injury results in better outcomes. For participants with moderate to severe ABI already in rehabilitation, 'strong evidence' revealed that more intensive programmes are associated with earlier functional gains, and 'moderate evidence' suggested that continued outpatient therapy could help to sustain gains made in early post-acute rehabilitation. The context of multi-disciplinary rehabilitation appears to influence outcomes. 'Strong evidence' supports the use of a milieu-oriented model for patients with severe brain injury, in which comprehensive cognitive rehabilitation takes place in a therapeutic environment and involves a peer group of patients. 'Limited evidence' shows that specialist in-patient rehabilitation and specialist multi-disciplinary community rehabilitation may provide additional functional gains, but studies serve to highlight the particular practical and ethical restraints imposed on randomisation of severely affected individuals for whom no realistic alternatives to specialist intervention are available. Authors' conclusions. Problems following ABI vary. Consequently, different interventions and combinations of interventions are required to meet the needs of patients with different problems. Patients who present acutely to hospital with mild brain injury benefit from follow-up and appropriate information and advice. Those with moderate to severe brain injury benefit from routine follow-up so their needs for rehabilitation can be assessed. Intensive intervention appears to lead to earlier gains, and earlier intervention whilst still in emergency and acute care has been supported by limited evidence. The balance between intensity and cost-effectiveness has yet to be determined. Patients discharged from in-patient rehabilitation benefit from access to out-patient or community-based services appropriate to their needs. Group-based rehabilitation in a therapeutic milieu (where patients undergo neuropsychological rehabilitation in a therapeutic environment with a peer group of individuals facing similar challenges) represents an effective approach for patients requiring neuropsychological rehabilitation following severe brain injury. Not all questions in rehabilitation can be addressed by randomised controlled trials or other experimental approaches. For example, trial-based literature does not tell us which treatments work best for which patients over the long term, and which models of service represent value for money in the context of life-long care. In the future, such questions will need to be considered alongside practice-based evidence gathered from large systematic longitudinal cohort studies conducted in the context of routine clinical practice

IgE-Mediated Hypersensitivity Reactions to Cannabis in Laboratory Personnel

Background: There have been sporadic reports of hypersensitivity reactions to plants of the Cannabinaceae family (hemp and hops), but it has remained unclear whether these reactions are immunologic or nonimmunologic in nature. Objective: We examined the IgE-binding and histamine-releasing properties of hashish and marijuana extracts by CAP-FEIA and a basophil histamine release test. Methods: Two workers at a forensic laboratory suffered from nasal congestion, rbinitis, sneezing and asthmatic symptoms upon occupational contact with hashish or marijuana, which they had handled frequently for 25 and 16 years, respectively. Neither patient had a history of atopic disease. Serum was analyzed for specific IgE antibodies to hashish or marijuana extract by research prototype ImmunoCAP, and histamine release from basophils upon exposure to hashish or marijuana extracts was assessed. Results were matched to those of 4 nonatopic and 10 atopic control subjects with no known history of recreational or occupational exposure to marijuana or hashish. Results: Patient 1 had specific IgE to both hashish and marijuana (CAP class 2), and patient 2 to marijuana only (CAP class 2). Controls proved negative for specific IgE except for 2 atopic individuals with CAP class 1 to marijuana and 1 other atopic individual with CAP class 1 to hashish. Stimulation of basophils with hashish or marijuana extracts elicited histamine release from basophils of both patients and 4 atopic control subjects. Conclusions: Our results suggest an IgE-related pathomechanism for hypersensitivity reactions to marijuana or hashish. Copyright (C) 2011 S. Karger AG, Base

Symmetry Analysis for the Ruddlesden-Popper Systems, Ca3Mn2O7 and Ca3Ti2O7

We perform a symmetry analysis of the zero-temperature instabilities of the tetragonal phase of Ca3Mn2O7 and Ca3Ti2O7 which is stable at high temperature. We introduce order parameters to characterize each of the possible lattice distortions in order to construct a Landau free energy which elucidates the proposed group-subgroup relations for structural transitions in these systems. We include the coupling between the unstable distortion modes and the macroscopic strain tensor. We also analyze the symmetry of the dominantly antiferromagnetic ordering which allows weak ferromagnetism. We show that in this phase the weak ferromagnetic moment and the spontaneous ferroelectric polarization are coupled, so that rotating one of these ordering by applying an external electric or magnetic field one can rotate the other ordering. We discuss the number of different domains (including phase domains) which exist in each of the phases and indicate how these may be observed.Comment: 21 pages, 14 figure