353 research outputs found
A Comparative study to assess the effectiveness and safety of cilnidipine versus amlodipine in patients with newly diagnosed essential hypertension: insights from a single centre prospective observational study
Background: Calcium channel blockers (CCBs) are proposed to play a pivotal role for the management and control of hypertension. Dihydropyridine-type calcium channel blockers (CCBs) like Amlodipine are frequently used because for their strong antihypertensive and minimal adverse side effects. However, it is commonly associated with the causation of pedal edema among the patients. Cilnidipine, which is a novel new generation calcium channel blocker, is presumed to cause lesser pedal edema with a satisfactory clinical control of hypertension along with negligible side effects. This study was carried out to compare clinical effectiveness and safety profile between Amlodipine and Cilnidipine.Methods: A prospective, randomized, open label study of 12 weeks’ duration was conducted amongst 60 patients with newly diagnosed essential hypertension. 30 patients of one group received Tab. Amlodipine 5 mg and 30 patients of same age groups received Tab. Cilnidipine 10mg.Results: There was a highly statistically significant decrease in the level of blood pressure in the Cilnidipine group compared to the Amlodipine group mainly at day 90 (P<0.001). Cilnidipine treated group had a fall in blood pressure of 23 ± 8 mmHg and the Amlodipine group had a decrease in the blood pressure of 12±7mmHg. Additionally, there was also significant reduction in pulse rate in the cilnidipine group. Only 4 patients in the Cilnidipine group developed ankle edema which completely disappeared at the end of 12 weeks of therapy compared to 9 patients in the Amlodipine group which persistently worsened at the completion of the study.Conclusions: Our study concluded that cilnidipine was a well-tolerated anti-hypertensive drug amongst patients with newly diagnosed essential hypertension and associated with minor adverse effects
The admissible tsunamigenic source region of 24 September 2013 land-based earthquake application of backward ray tracing technique
A minor tsunami of about 50 cm was generated along the coast of Qurayat near Makran subduction zone in the
Arabian Sea due to the 24 September 2013 Pakistan earthquake of magnitude 7.6 Mw(mB),although its source was ~200 km far inland of the Makran trench. The real time sea
level observation network in the Arabian Sea recorded minor tsunami arrivals. In an attempt to explain the mechanism
of this unusual tsunami, we use backward ray tracing technique to map the admissible region of tsunamigenic source. Basically, in this technique the ray equations are integrated starting from the specific locations of tsunami
observations, in all possible directions. The known travel time of the initial waves to the respective tide gauges and tsunami buoys is used in this method. Backward wave front is constructed by joining all endpoints of the rays from each of the locations. The region where the envelope of all backward wave fronts converges is considered as the source of the tsunami, which is ~470 km from the earthquake epicentre with the location at 24.8 N and 61.5E. The admissible region identified is an undersea section between Chabahar and Gwadar, where a mud island had appeared subsequent to this earthquake. Convergence of the tsunami source zone and location of the mud island suggest that the sudden uplift must have caused the tsunam
Raman Evidence for Superconducting Gap and Spin-Phonon Coupling in Superconductor Ca(Fe0.95Co0.05)2As2
Inelastic light scattering studies on single crystal of electron-doped
Ca(Fe0.95Co0.05)2As2 superconductor, covering the tetragonal to orthorhombic
structural transition as well as magnetic transition at TSM ~ 140 K and
superconducting transition temperature Tc ~ 23 K, reveal evidence for
superconductivity-induced phonon renormalization; in particular the phonon mode
near 260 cm-1 shows hardening below Tc, signaling its coupling with the
superconducting gap. All the three Raman active phonon modes show anomalous
temperature dependence between room temperature and Tc i.e phonon frequency
decreases with lowering temperature. Further, frequency of one of the modes
shows a sudden change in temperature dependence at TSM. Using first-principles
density functional theory-based calculations, we show that the low temperature
phase (Tc < T < TSM) exhibits short-ranged stripe anti-ferromagnetic ordering,
and estimate the spin-phonon couplings that are responsible for these phonon
anomalies
Theory of a Higher Order Phase Transition: Superconducting Transition in BKBO
We describe here the properties expected of a higher (with emphasis on the
order fourth) order phase transition. The order is identified in the sense
first noted by Ehrenfest, namely in terms of the temperature dependence of the
ordered state free energy near the phase boundary. We have derived an equation
for the phase boundary in terms of the discontinuities in thermodynamic
observables, developed a Ginzburg-Landau free energy and studied the
thermodynamic and magnetic properties. We also discuss the current status of
experiments on and other based superconductors,
the expectations for parameters and examine alternative explanations of the
experimental results.Comment: 18 pages, no figure
Effects of Next-Nearest-Neighbor Hopping on the Hole Motion in an Antiferromagnetic Background
In this paper we study the effect of next-nearest-neighbor hopping on the
dynamics of a single hole in an antiferromagnetic (N\'{e}el) background. In the
framework of large dimensions the Green function of a hole can be obtained
exactly. The exact density of states of a hole is thus calculated in large
dimensions and on a Bethe lattice with large coordination number. We suggest a
physically motivated generalization to finite dimensions (e.g., 2 and 3). In
we present also the momentum dependent spectral function. With varying
degree, depending on the underlying lattice involved, the discrete spectrum for
holes is replaced by a continuum background and a few resonances at the low
energy end. The latter are the remanents of the bound states of the
model. Their behavior is still largely governed by the parameters and .
The continuum excitations are more sensitive to the energy scales and
.Comment: To appear in Phys. Rev. B, Revtex, 23 pages, 10 figures available on
request from [email protected]
Synthesis, Characterization of Nano MnO2 and its Adsorption Characteristics Over an Azo Dye
ABSTRACT Nano MnO2 powder was synthesized by low temperature solution combustion method using oxalyl dihydrazide (ODH) fuel. The final product was well characterized by Powder X-ray diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning electron microscopy (SEM) for crystallographic purity, phase formation and surface morphology respectively. PXRD results show that pure MnO2 was synthesized at 300 0 C with no other impurities. SEM micrograph shows the product has highly porous structure with large voids, typical of combustion derived material. An adsorption characteristic of the porous MnO2 was studied over direct green dye (DG). The optimum dose of MnO2 for removal of 10 ppm DG azo dye was found to be 0.4 g L -1
Izrada i karakterizacija IPN alginatnih i želatinskih mikrogelova s tramadolom: Optimiranje pomoću metode odzivnih površina
Tramadol-loaded interpenetrating polymer network (IPN) alginate-gelatin (AG) microgels (MG) were prepared by the chemical cross-linking technique with glutaraldehyde as cross-linking agent and were optimized using response surfaces. A central composite design for 2 factors, at 3 levels each, was employed to evaluate the effect of critical formulation variables, namely the amount of gelatin (X1) and glutaraldehyde (X2) on geometric mean diameter, encapsulation efficiency, diffusion coefficient (D), amount of mucin adsorbed per unit mass (Qe) and 50 % drug release time (t50). Microgels with average particle size in the range of 44.31102.41 m were obtained. Drug encapsulation up to 86.5 % was achieved. MGs were characterized by FT-IR spectroscopy to assess formation of the IPN structure and differential scanning calorimetry (DSC) was performed to understand the nature of drug dispersion after encapsulation into IPN microgels. Both equilibrium and dynamic swelling studies were performed in pH 7.4 phosphate buffer. Diffusion coefficients and exponents for water transport were determined using an empirical equation. The mucoadhesive properties of MGs were evaluated in aqueous solution by measuring the mucin adsorbed on MGs. Adsorption isotherms were constructed and fitted with Freundlich and Langmuir equations. In vitro release studies indicated the dependence of drug release on the extent of crosslinking and amount of gelatin used in preparing IPNs. The release rates were fitted to power law equation and Higuchi’s model to compute the various drug transport parameters, n value ranged from 0.4055 to 0.5754, suggesting that release may vary from Fickian to quasi-Fickian depending upon variation in the formulation composition.Interpenetrirajući umreženi polimerni (IPN) alginatno-želatinski (AG) mikrogelovi (MG) tramadola pripravljeni su metodom umrežavanja koristeći glutaraldehid kao sredstvo za umrežavanje. Pripravci su optimirani pomoću odzivnih površina. Kompozitini dizajn s dva faktora na tri nivoa upotrijebljen je za procjenu kritičnih formulacijskih varijabli: praćen je utjecaj količine želatine (X1) i glutaraldehida (X2) na prosječnu veličinu čestica, sposobnost kapsuliranja, koeficijent difuzije (D), količinu adsorbiranog mucina po jedinici mase (Qe) i vrijeme potrebno za oslobađanje 50 % lijeka (t50). Dobiveni su mikrogelovi prosječne veličine čestica od 44,31 do 102,41 m, a maksimalno postignuto vezanje lijeka bilo je 86,5 %. Mikrogelovi su karakterizirani FT-IR spektroskopijom i diferencijalnom pretražnom kalorimetrijom (DSC). Ravnotežne i dinamičke studije bubrenja provedene su u fosfatnom puferu pH 7,4. Koeficijenti difuzije i eksponenti za transport vode određeni su pomoću empirijske jednadžbe. Mukoadhezivna svojstva MGs evaluirana su u vodenoj otopini mjerenjem adsorpcije mucina na mikrogelove. Konstruirane su adsorpcijske izoterme i uspoređene s Freudlichovim i Langmuirovim jednadžbama. Pokusi in vitro pokazuju da oslobađanje ljekovite tvari ovisi o stupnju umreženja i količini želatine upotrijebljene u pripravi IPN. Vrijednosti oslobađanja uvrštene su u jednadžbu zakona potencije i u Higuchijev model kako bi se izračunali razni parametri prijenosa lijeka; n vrijednosti bile su između 0,4055 i 0,5754, što ukazuje na to da oslobađanje varira od Fickovog do kvazi-Fickovog, ovisno o sastavu pripravka
Mesoflowers: A new class of highly efficient surface-enhanced Raman active and infrared-absorbing materials
Systemic AAV vectors for widespread and targeted gene delivery in rodents
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel AAV variants was not previously available. In this protocol, we describe how to produce and intravenously administer AAVs to adult mice to specifically label and/or genetically manipulate cells in the nervous system and organs, including the heart. The procedure comprises three separate stages: AAV production, intravenous delivery, and evaluation of transgene expression. The protocol spans 8 d, excluding the time required to assess gene expression, and can be readily adopted by researchers with basic molecular biology, cell culture, and animal work experience. We provide guidelines for experimental design and choice of the capsid, cargo, and viral dose appropriate for the experimental aims. The procedures outlined here are adaptable to diverse biomedical applications, from anatomical and functional mapping to gene expression, silencing, and editing
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