Left main bronchus compression due to main pulmonary artery dilatation in pulmonary hypertension: two case reports

Abstract. Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described. Tracheobronchial compression from pulmonary arterial dilatation is rare in adults, and there are no reports in the literature of its occurrence in idiopathic pulmonary arterial hypertension. Compression in infants with congenital heart disease has been well described. We report 2 cases of tracheobronchial compression: first, an adult patient with idiopathic pulmonary arterial hypertension who presents with symptomatic left main bronchus compression, and second, an adult patient with Eisenmenger ventricular septal defect and right-sided aortic arch, with progressive intermedius and right middle lobe bronchi compression in association with enlarged pulmonary arteries

Languages and Learning at Key Stage 2: A Longitudinal Study Final Report

In 2006, The Open University, the University of Southampton and Canterbury Christ Church University were commissioned by the then Department for Education and Skills (DfES), now Department for Children, Schools and Families (DCSF) to conduct a three-year longitudinal study of languages learning at Key Stage 2 (KS2). The qualitative study was designed to explore provision, practice and developments over three school years between 2006/07 and 2008/09 in a sample of primary schools and explore children’s achievement in oracy and literacy, as well as the possible broader cross-curricular impact of languages learning

The automorphism group of separable states in quantum information theory

We show that the linear group of automorphism of Hermitian matrices which preserves the set of separable states is generated by \emph{natural} automorphisms: change of an orthonormal basis in each tensor factor, partial transpose in each tensor factor, and interchanging two tensor factors of the same dimension. We apply our results to preservers of the product numerical range.Comment: 15 page

Deformed Penrose tilings

Monte Carlo (MC) simulation of a model quasicrystal (2D Penrose rhomb tiling) shows that the kinds of local distortions that result from size-effect-like relaxations are in fact very similar to mathematical constructions called deformed model sets. Of particular interest is the fact that these deformed model sets are pure point-diffractive, i.e. they give diffraction patterns that have sharp Bragg peaks and no diffuse scattering. Although the aforementioned MC simulations give diffraction patterns displaying some diffuse scattering, this can be attributed to the fact that the simulations include a certain amount of unavoidable randomness. Examples of simple deformed model sets have been constructed by simple prescription and hence contain no randomness. In this case the diffraction patterns show no diffuse scattering. It is demonstrated that simple deformed model sets can be constructed, based on the 2D Penrose rhomb tiling, by using deformations which are defined in terms of the local environment of each vertex. The resulting model sets are all topologically equivalent to the Penrose tiling (same connectedness), are perfectly quasicrystalline but show an enormous variation in the Bragg peak intensities. For the examples described, which are based on nearest-neighbour environments, 12 deformation parameters may be chosen independently. If more distant neighbours are taken into account further sets of parameters may be defined. One example of these simple deformed tilings, which shows great similarity to the size-effect-distorted tiling, is discussed in detail

Pressure-induced insulator-to-metal transition in low-dimensional TiOCl

We studied the transmittance and reflectance of the low-dimensional Mott-Hubbard insulator TiOCl in the infrared and visible frequency range as a function of pressure. The strong suppression of the transmittance and the abrupt increase of the near-infrared reflectance above 12 GPa suggest a pressure-induced insulator-to-metal transition. The pressure-dependent frequency shifts of the orbital excitations, as well as the pressure dependences of the charge gap and the spectral weight of the optical conductivity above the phase transition are presented.Comment: 4 pages, 6 figure

IL-17-producing γδ T cells protect against Clostridium difficile infection

Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and mortality, especially after antibiotic use in health care settings. The natural immunity of newborn infants and protective host immune mediators against C. difficile infection are not fully understood, with data suggesting that inflammation can be either protective or pathogenic. Here, we show an essential role for IL-17A produced by γδ T cells in host defense against C. difficile infection. Fecal extracts from children with C. difficile infection showed increased IL-17A and T cell receptor γ chain expression, and IL-17 production by intestinal γδ T cells was efficiently induced after infection in mice. C. difficile-induced tissue inflammation and mortality were markedly increased in mice deficient in IL-17A or γδ T cells. Neonatal mice, with naturally expanded RORγt+ γδ T cells poised for IL-17 production were resistant to C. difficile infection, whereas elimination of γδ T cells or IL-17A each efficiently overturned neonatal resistance against infection. These results reveal an expanded role for IL-17-producing γδ T cells in neonatal host defense against infection and provide a mechanistic explanation for the clinically observed resistance of infants to C. difficile colitis

Ethyl 4-(2,4-difluoro­phen­yl)-6-methyl-2-oxo-1,2,3,4-tetra­hydro­pyrimidine-5-carboxyl­ate

In the title compound, C14H14F2N2O3, the dihydro­pyrimidin­one ring adopts a flattened boat conformation. The difluoro­phenyl group is disordered over two orientations with occupancies of 0.544 (3) and 0.456 (3). The methoxy­carbonyl group is disordered over two positions with occupancies of 0.580 (8) and 0.420 (8). In the crystal, mol­ecules are linked into centrosymmetric dimers by paired N—H⋯O hydrogen bonds and the dimers are linked into a ribbon-like structure along [100] by further N—H⋯O hydrogen bonds

Conceptual Aerodynamic Design of a Tail-Cone Thruster System Under Axi-Symmetric Inlet Distortion

This paper presents a conceptual design of a tail-cone thruster system which is operating under an axisymmetric inlet distortion. An effort to realize the targeted fuel burn saving that was proposed in NASA's STARC_ABL aircraft design is made through a CFD (Computational Fluid Dynamics)-based design approach. This method employs three iterative steps to exploit the CFD tools until the design requirements are met: a quasi-2D through-flow model to design the fan/EGV (Exit Guide Vane), a 3-D RANS (Reynolds Averaging Navier-Stokes) simulation of the single blade row to account for the inlet/fan and the EGV/nozzle interaction, and a 3-D RANS simulation of the airframe with a propulsor installed - propulsion airframe integration (PAI). The design requirements which include the thrust, and shaft power of the propulsor are matched throughout the evaluations coming from two CFD domains, i.e., the turbo-machinery and the PAI. During the switch between these different computational domains, the inlet and exit profiles are matched via the correction factors of the body-force model. The present tail-cone thruster (TCT) aerodynamic design leverages a low-pressure ratio fan (FPR=1.2 to approximately 1.25) of which the camber-line angles are predicted by a quasi-2D through-flow model. The quasi-2D model is derived to analyze the radially distorted flow resulting from the ingested boundary layer at the inlet. It also estimates the appropriate velocity vectors of the metal angles of the fan and EGV which is subjected to different types of vortex at the fan exit. The baseline geometry is revisited and its internal flow-path and exhaust cone are redesigned to illustrate the strong correlation among the components of the propulsor in the PAI domain. The peak efficiency point of the fan/EGV with respect to the blade counts, also known as solidity, and rotational speed is chosen for the cruise condition via parametric studies. The corresponding performance maps are presented. The resulting performance metrics of the new conceptual design of the BLI (Boundary Layer Ingestion) propulsor are analyzed and compared with these of the baseline in the PAI aspect. Finally, ideas of the CFD based design of a BLI propulsor are discussed based on the observations drawn from the numerical results