3-Chloro-4-hydr­­oxy-4′-methyl­benzo­phenone

The title compound, C14H11ClO2, possesses normal geometrical parameters. The two benzene rings are twisted by 54.70 (4)°, perhaps as a result of steric repulsion between H atoms. The crystal packing is consolidated by an O—H⋯O hydrogen bond, π–π stacking and C—H⋯O and C—H⋯π inter­actions, resulting in a two-dimensional network

Scavenging Efficiency of Activated Charcoal of Sweet Corn Cop and Areca Nut Shell for Carcinogenic Salicylic Acid and Methylene Blue

Activated plant charcoal plays major role in adsorption chemistry and finds a huge application in industry, pharmaceuticals, cosmetics and water treatment. Present work planned to utilize waste sweet corn cop and areca nut husk to prepare charcoal by chemical method. The charcoal was carbonized at 8000C using muffle furnace. The adsorption efficiency of the experimental activated carbon adsorbents towards the model organic compounds methylene blue and salicylic acid were assessed by UV-Vis spectrophotometric method. Experimental results clearly indicates that sweet corn cop charcoal recorded maximum absorption for salicylic acid 640ppm/g in compare to areca nut shell husk charcoal 480ppm/g. Sweet corn cop charcoal recorded optimum absorption for methylene blue 240 ppm/g in compare to areca nut shell husk charcoal 240ppm/g. The experimental charcoal projects noticeable results in scavenging salicylic acid and methylene blue from polluted samples. This experimental results and affordable cost the raw material made the sweet corn cop and areca nut husk activated carbon a powerful alternative for the adsorption of carcinogenic organic compounds salicylic acid and methylene blue

Synthesis and biological screening of pyrazole moiety containing analogs of podophyllotoxin

The pyrazole moiety containing analogs of podophyllotoxin as potential antimitotic agents were synthesized in five step reactions via chalcone route. The first step is the synthesis of chalcone (2a-d) by the reaction of substituted acetophenones with p-tolualdehyde in the presence of sodium hydroxide in water-ethanol mixture. The cyclopropyl ketones (3a-d) were prepared by the reaction of chalcones (2a-d) with trimethylsulfoxonium iodide (TMSOI) in dry DMSO. The key intermediate tetralones (4a-d) were prepared by the intramolecular cyclization reaction of cyclopropyl ketones (3a-d) in the presence of anhyd. stannic chloride and acetic anhydride in dry dichloromethane. These compounds (4a-d) on formylation give substituted hydroxylmethylene tetralones (5a-d). Further, pyrazole moiety containing analogs of podophyllotoxin (6a-d) were synthesized in high yields by the condensation of hydroxylmethylene tetralones (5a-d) with hydrazine hydrate in absolute ethanol. The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. The synthesized compounds were also screened for their antimitotic activity. It is noteworthy that compounds 6d possessed excellent antimitotic activity, 6b and 6c showed considerable activity, and remaining 6a possessed least activity. Compound 6d was immense to show high antibacterial and antifungal activity against all bacterial and fungal strains compared with standard chloramphenicol and nystatin, respectively