The effects of maternal age and parity on birth weight in a tribal community of Kinwat, Nanded, Maharashtra, India

Background: Low birth weight is an important determinant of childhood morbidity and mortality. Birth weight is a significant factor that determines vulnerability of risk of childhood illness and survival. Objective of the study was to correlate the maternal age and parity on birth weight in a tribal community.Methods: A cross-sectional study was carried out during April 2012 to June 2014 in More Nursing Home, Kinwat Dist. Nanded, Maharashtra. A total of 1611 patients from tribal area who delivered in the nursing home were enclosed for the study. Data was analyzed by using SSPS version-18.0.Results: In this study low birth weight babies were seen in 18.56% and 17.78% and 21.47% of female and male babies had low birth weight respectively, which was statistically significant.  Mean birth weight increased as parity of mother increased. Low birth weight babies were born to the mother of younger age which was statistically significant.Conclusions: Health care of young age tribal mothers is important factor in curbing low birth weight babies

Concept of Diabetic Neuropathy and its management in Ayurveda

Diabetes mellitus is a giant disease considered as one of the arch enemies of the mankind. The evidences at present suggest that incidence of Diabetes mellitus is raising among the general population. In Ayurveda, Diabetes mellitus closely resembles a disorder called Madhumeha, which is a subtype of Vataja Prameha. In Avarnjanya Madhumeha vitiated Kapha, Pitta and Meda causes Avarana to Vata that leads its aggravation causing diminution of vital Dhatus. This may lead to the complication of Madhumeha such as Diabetic Neuropathy. According to Ayurvedic principles there is involvement of Vata and Pitta Dosha in diabetic neuropathy. The drugs used conventionally are mostly for relief in the symptoms and moreover they have certain side effects. Many single drugs and Ayurvedic formulations are used in practice have significant effect on the symptoms of numbness, tingling, burning sensation and pain in the patients of diabetic neuropathy

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Mutations in KIT and TET2 are associated with myeloid malignancies. We show that loss of TET2-induced PI3K activation and -increased proliferation is rescued by targeting the p110α/δ subunits of PI3K. RNA-Seq revealed a hyperactive c-Myc signature in Tet2-/- cells, which is normalized by inhibiting PI3K signaling. Loss of TET2 impairs the maturation of myeloid lineage-derived mast cells by dysregulating the expression of Mitf and Cebpa, which is restored by low-dose ascorbic acid and 5-azacytidine. Utilizing a mouse model in which the loss of TET2 precedes the expression of oncogenic Kit, similar to the human disease, results in the development of a non-mast cell lineage neoplasm (AHNMD), which is responsive to PI3K inhibition. Thus, therapeutic approaches involving hypomethylating agents, ascorbic acid, and isoform-specific PI3K inhibitors are likely to be useful for treating patients with TET2 and KIT mutations

Genome‐wide linkage analysis and whole‐exome sequencing identifies an ITGA2B mutation in a family with thrombocytopenia

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150531/1/bjh15961_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150531/2/bjh15961.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150531/3/bjh15961-sup-0001-DataS1.pd

Evolution of magnetic polarons and spin-carrier interactions through the metal-insulator transition in Eu1−x_{1-x}Gdx_{x}O

Raman scattering studies as functions of temperature, magnetic field, and Gd-substitution are used to investigate the evolution of magnetic polarons and spin-carrier interactions through the metal-insulator transition in Eu$_{1-x}$Gd$_{x}$O. These studies reveal a greater richness of phase behavior than have been previously observed using transport measurements: a spin-fluctuation-dominated paramagnetic (PM) phase regime for T $>$ T$^{*}$ $>$ T$_{C}$, a two-phase regime for T $<$ T$^{*}$ in which magnetic polarons develop and coexist with a remnant of the PM phase, and an inhomogeneous ferromagnetic phase regime for T $<$ T$_{C}$

Infrared Nonlinear Optics

Contains reports on six research projects.Defense Advanced Research Projects Agency Universities Research Initiative (Contract N00014-46-K-0760)Strategic Defense Initiative/Innovative Science & Technology, managed by the U.S. Naval Research Laboratory (Contract N00014-87-K-2031)National Science Foundation (Grant EET-87-18417

Seasonal variations in ostracod species in two freshwater lakes in Yavatmal District (Maharashtra) India

The diversity and density of ostracods (zooplankton) in two freshwater lakes in the Yavatmal district of Maharashtra, India, were studied from June 2020 to May 2021 to determine seasonal variations. Plankton net (64m pore size) was used to collect the samples and analysis was performed using standard keys. In all, 11 species from 8 genera belonging to 3 families of Ostracoda were identified from Mama Lake and Singhada Lake of the Yavatmal district of Maharashtra, India. The overall population of Ostracoda is greater in Mama Lake than in Singhada Lake. Additionally, the species diversity was higher in the summer season and lowest in winter

Theoretical Study on Superconductivity in Boron-Doped Diamond

We consider superconductivity in boron (B) doped diamond using a simplified model for the valence band of diamond. We treat the effects of substitutional disorder of B ions by the coherent potential approximation (CPA) and those of the attractive force between holes by the ladder approximation under the assumption of instantaneous interaction with the Debye cutoff. We thereby calculate the quasiparticle life time, the evolution of the single-particle spectra due to doping, and the effect of disorder on the superconducting critical temperature $T_c$. We in particular compare our results with those for supercell calculations to see the role of disorder, which turns out to be of crucial importance to $T_c$.Comment: 9 pages, 13 figures, submitted to J. Phys. Soc. Jpn., Errors in embedded eps figure files have been correcte

A study of referral bias in NMOSD and MOGAD cohorts.

BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres. We aimed to assess if cohort characteristics depend on the origin of the referral catchment areas serviced by our centre (i.e. local, regional or national). METHODS: Retrospective cohort study using a national referral service database including local (Oxfordshire), regional (Oxfordshire and neighbouring counties), and national patients. We included patients with the diagnosis of NMOSD, seronegative NMOSD or MOGAD, followed at the Oxford Neuromyelitis Optica Service. RESULTS: We included 720 patients (331 with MOGAD, 333 with aquaporin-4 antibody (AQP4)-NMOSD, and 56 with seronegative NMOSD. The distribution of diagnoses was similar across referral cohorts. There were no significant differences in the proportion of pediatric onset patients, sex, or onset phenotype; more White AQP4-NMOSD patients were present in the local than in the national cohort (81 % vs 52 %). Despite no differences in follow-up time, more relapsing MOGAD disease was present in the national than in the local cohort (42.9 % vs. 24 %, p = 0.029). CONCLUSION: This is the first study assessing the impact of potential referral bias in cohorts of NMOSD or MOGAD. The racial difference in the AQP4-NMOSD cohorts likely reflects the variation in the population demographics rather than a referral bias. The over representation of relapsing MOGAD patients in the national cohort probably is a true referral bias and highlights the need to analyze incident cohorts when describing disease course and prognosis. It seems reasonable therefore to compare MOGAD and NMOSD patients seen withing specialised centres to general neurology services, provided both use similar antibody assays