2,052 research outputs found
Scale-invariance in gravity and implications for the cosmological constant
Recently a scale invariant theory of gravity was constructed by imposing a
conformal symmetry on general relativity. The imposition of this symmetry
changed the configuration space from superspace - the space of all Riemannian
3-metrics modulo diffeomorphisms - to conformal superspace - the space of all
Riemannian 3-metrics modulo diffeomorphisms and conformal transformations.
However, despite numerous attractive features, the theory suffers from at least
one major problem: the volume of the universe is no longer a dynamical
variable. In attempting to resolve this problem a new theory is found which has
several surprising and atractive features from both quantisation and
cosmological perspectives. Furthermore, it is an extremely restrictive theory
and thus may provide testable predictions quickly and easily. One particularly
interesting feature of the theory is the resolution of the cosmological
constant problem.Comment: Replaced with final version: minor changes to text; references adde
Scale-invariant gravity: Spacetime recovered
The configuration space of general relativity is superspace - the space of
all Riemannian 3-metrics modulo diffeomorphisms. However, it has been argued
that the configuration space for gravity should be conformal superspace - the
space of all Riemannian 3-metrics modulo diffeomorphisms and conformal
transformations. Recently a manifestly 3-dimensional theory was constructed
with conformal superspace as the configuration space. Here a fully
4-dimensional action is constructed so as to be invariant under conformal
transformations of the 4-metric using general relativity as a guide. This
action is then decomposed to a (3+1)-dimensional form and from this to its
Jacobi form. The surprising thing is that the new theory turns out to be
precisely the original 3-dimensional theory. The physical data is identified
and used to find the physical representation of the theory. In this
representation the theory is extremely similar to general relativity. The
clarity of the 4-dimensional picture should prove very useful for comparing the
theory with those aspects of general relativity which are usually treated in
the 4-dimensional framework.Comment: Replaced with final version: minor changes to tex
The physical gravitational degrees of freedom
When constructing general relativity (GR), Einstein required 4D general
covariance. In contrast, we derive GR (in the compact, without boundary case)
as a theory of evolving 3-dimensional conformal Riemannian geometries obtained
by imposing two general principles: 1) time is derived from change; 2) motion
and size are relative. We write down an explicit action based on them. We
obtain not only GR in the CMC gauge, in its Hamiltonian 3 + 1 reformulation but
also all the equations used in York's conformal technique for solving the
initial-value problem. This shows that the independent gravitational degrees of
freedom obtained by York do not arise from a gauge fixing but from hitherto
unrecognized fundamental symmetry principles. They can therefore be identified
as the long-sought Hamiltonian physical gravitational degrees of freedom.Comment: Replaced with published version (minor changes and added references
The influence of paediatric HIV infection on circulating B cell subsets and CXCR5+ T helper cells
Antiretroviral therapy (ART) only partially restores HIV-induced alterations in lymphocyte populations. We assessed B and T cell phenotypes in a cohort of children from a single centre in the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority of HIV infected children (44 of 56) were on fully suppressive combination ART. Children with perinatally acquired HIV had significantly lower memory B and CD4(+) CD45RO(+) CXCR5(+) [follicular T helper cell (Tfh)-like] T cell percentages. Detectable viraemia was associated with higher CD21(-) (activated and exhausted/tissue-like memory) B cells. A greater proportion of life spent on suppressive ART was associated with higher memory B cell percentages. These results suggest that early and sustained suppressive ART may preserve B and T cell phenotypes in perinatally acquired HIV and limit deficits in humoral immunity. A lower proportion of circulating Tfh-like cells in HIV infected children appears to be independent of HIV treatment history and ongoing HIV viraemia and warrants further investigation
Serological response to 13-valent pneumococcal conjugate vaccine in children and adolescents with perinatally acquired HIV infection
BACKGROUND: Children with perinatally acquired HIV (paHIV) remain at an increased risk of pneumococcal infection despite highly active antiretroviral therapy (HAART). Beyond infancy, responses to pneumococcal conjugate vaccine (PCV) remain under-investigated. There are currently no published data on serological response to 13-valent PCV (PCV13) in the HIV-infected populations. METHODS: We measured pneumococcal serotype-specific IgG in 48 paHIV-infected child patients (CP), 27 young adult healthy controls (AHC) and 30 child healthy controls (CHC). Opsonophagocytic assay (OPA) titres for three PCV13-exclusive serotypes were measured in a subset of children. Serotype-specific IgG was repeated 1 and 6 months following PCV13 vaccination of CP and AHC groups. OPA titres for four serotypes were measured at the 1-month time-point. RESULTS: The majority of CP, CHC and AHC had serotype-specific IgG above 0.35 μg/ml at baseline, although OPA activity was undetectable for two of the three serotypes studied. Baseline IgG concentrations were significantly lower in CP than AHC for a proportion of serotypes and were strongly predictive of responses to vaccine. After adjusting for baseline, postvaccination IgG concentrations were comparable, although responses to some serotypes were impaired for CP. OPA correlated well with IgG after vaccination. Detectable HIV viral load was associated with significantly lower IgG concentration and OPA titre. CONCLUSION: Children with paHIV mount a robust serological response to PCV13 for most but not all vaccine serotypes. Viral load suppression with HAART and higher baseline IgG concentration are associated with higher postvaccination antibody levels. This has implications for HAART treatment and vaccination practices
Moments of the neutron g(2) structure function at intermediate Q(2)
We present new experimental results for the He-3 spin structure function g(2) in the resonance region atQ 2 values between 1.2 and 3.0 (GeV/c)(2). Spin dependent moments of the neutron were extracted. Our main result, the inelastic contribution to the neutron d(2) matrix element, was found to be small at \u3c Q(2)\u3e = 2.4 (GeV/c)(2) and in agreement with the lattice QCD calculation. The Burkhardt-Cottingham sum rule for He-3 and the neutron was tested with the measured data and using the Wandzura-Wilczek relation for the low x unmeasured region
Beam-Target Double-Spin Asymmetry A(LT) in Charged Pion Production from Deep Inelastic Scattering on a Transversely Polarized He-3 Target at 1.4 \u3c Q(2) \u3c 2.7 GeV2
We report the first measurement of the double-spin asymmetry A(LT) for charged pion electroproduction in semi-inclusive deep-inelastic electron scattering on a transversely polarized He-3 target. The kinematics focused on the valence quark region, 0.16 \u3c x \u3c 0.35 with 1.4 \u3c Q(2) \u3c 2.7 GeV2. The corresponding neutron A(LT) asymmetries were extracted from the measured He-3 asymmetries and proton over He-3 cross section ratios using the effective polarization approximation. These new data probe the transverse momentum dependent parton distribution function g(1T)(q) and therefore provide access to quark spin-orbit correlations. Our results indicate a positive azimuthal asymmetry for pi(-) production on He-3 and the neutron, while our pi(+) asymmetries are consistent with zero
Transmission of High-Power Electron Beams Through Small Apertures
Tests were performed to pass a 100 MeV, 430 kWatt c.w. electron beam from the
energy-recovery linac at the Jefferson Laboratory's FEL facility through a set
of small apertures in a 127 mm long aluminum block. Beam transmission losses of
3 p.p.m. through a 2 mm diameter aperture were maintained during a 7 hour
continuous run.Comment: arXiv admin note: text overlap with arXiv:1305.019
Measurement of pretzelosity asymmetry of charged pion production in semi-inclusive deep inelastic scattering on a polarized He-3 target
An experiment to measure single-spin asymmetries of semi-inclusive production of charged pions in deep-inelastic scattering on a transversely polarized He-3 target was performed at Jefferson Laboratory in the kinematic region of 0.16 \u3c x \u3c 0.35 and 1.4 \u3c Q(2) \u3c 2.7 GeV2. Pretzelosity asymmetries on He-3, which are expressed as the convolution of the h(1T)(perpendicular to) transverse-momentum-dependent distribution functions and the Collins fragmentation functions in the leading order, were measured for the first time. Under the effective polarization approximation, we extracted the corresponding neutron asymmetries from the measured He-3 asymmetries and cross-section ratios between the proton and He-3. Our results show that both pi(+) on He-3 and on neutron pretzelosity asymmetries are consistent with zero within experimental uncertainties
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