Herschel photometric observations of the low metallicity dwarf galaxy NGC 1705

We present Herschel SPIRE and PACS photometeric observations of the low metallicity (Z ~ 0.35 Z_☉) nearby dwarf galaxy, NGC 1705, in six wavelength bands as part of the Dwarf Galaxy Survey guaranteed time Herschel key program. We confirm the presence of two dominant circumnuclear IR-bright regions surrounding the central super star cluster that had been previously noted at mid-IR wavelengths and in the sub-mm by LABOCA. On constructing a global spectral energy distribution using the SPIRE and PACS photometry, in conjunction with archival IR measurements, we note the presence of an excess at sub-mm wavelengths. This excess suggests the presence of a significant cold dust component within NGC 1705 and was modeled as an additional cold component in the SED. Although alternative explanations for the sub-mm excess beyond 350 μm, such as changes to the dust emissivity cannot be ruled out, the most likely explanation for the observed submillimetre excess is that of an additional cold dust component

Corpus-assisted literary evaluation

Fleur Adcock’s poem, Street Song, is evaluated by the stylistician, Roger Fowler, as ‘dynamic and disturbing’. I agree with his literary evaluation. These unsettling effects take place in initial response to the poem, effects which attract me into the work. In other words, they are experienced before proper reflection and analysis of the poem and individual interpretation of it. Implicit within Fowler’s evaluation is that this is likely to apply for readers generally. The purpose of this article is to show how empirical corpus evidence can usefully provide substantiation of such initial evaluations of literary works, showing whether or not they are likely to be stereotypically experienced by readers. In drawing on both schema theory and corpus analysis to achieve this, the article makes links between cognitive stylistic and corpus stylistic foci

Sex, stress and sleep apnoea: decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females

Obstructive sleep apnoea syndrome (OSAS) is a devastating respiratory control disorder more common in men than women. The reasons for the sex difference in prevalence are multifactorial, but are partly attributable to protective effects of oestrogen. Indeed, OSAS prevalence increases in post-menopausal women. OSAS is characterized by repeated occlusions of the pharyngeal airway during sleep. Dysfunction of the upper airway muscles controlling airway calibre and collapsibility is implicated in the pathophysiology of OSAS, and sex differences in the neuro-mechanical control of upper airway patency are described. It is widely recognized that chronic intermittent hypoxia (CIH), a cardinal feature of OSAS due to recurrent apnoea, drives many of the morbid consequences characteristic of the disorder. In rodents, exposure to CIH-related redox stress causes upper airway muscle weakness and fatigue, associated with mitochondrial dysfunction. Of interest, in adults, there is female resilience to CIH-induced muscle dysfunction. Conversely, exposure to CIH in early life, results in upper airway muscle weakness equivalent between the two sexes at 3 and 6 weeks of age. Ovariectomy exacerbates the deleterious effects of exposure to CIH in adult female upper airway muscle, an effect partially restored by oestrogen replacement therapy. Intriguingly, female advantage intrinsic to upper airway muscle exists with evidence of substantially greater loss of performance in male muscle during acute exposure to severe hypoxic stress. Sex differences in upper airway muscle physiology may have relevance to human OSAS. The oestrogen–oestrogen receptor α axis represents a potential therapeutic target in OSAS, particularly in post-menopausal women

Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat

Alterations to the supply of oxygen during early life presents a profound stressor to physiological systems with aberrant remodeling that is often long-lasting. Chronic intermittent hypoxia (CIH) is a feature of apnea of prematurity, chronic lung disease, and sleep apnea. CIH affects respiratory control but there is a dearth of information concerning the effects of CIH on respiratory muscles, including the diaphragm—the major pump muscle of breathing. We investigated the effects of exposure to gestational CIH (gCIH) and postnatal CIH (pCIH) on diaphragm muscle function in male and female rats. CIH consisted of exposure in environmental chambers to 90 s of hypoxia reaching 5% O2 at nadir, once every 5 min, 8 h a day. Exposure to gCIH started within 24 h of identification of a copulation plug and continued until day 20 of gestation; animals were studied on postnatal day 22 or 42. For pCIH, pups were born in normoxia and within 24 h of delivery were exposed with dams to CIH for 3 weeks; animals were studied on postnatal day 22 or 42. Sham groups were exposed to normoxia in parallel. Following gas exposures, diaphragm muscle contractile, and endurance properties were examined ex vivo. Neither gCIH nor pCIH exposure had effects on diaphragm muscle force-generating capacity or endurance in either sex. Similarly, early life exposure to CIH did not affect muscle tolerance of severe hypoxic stress determined ex vivo. The findings contrast with our recent observation of upper airway dilator muscle weakness following exposure to pCIH. Thus, the present study suggests a relative resilience to hypoxic stress in diaphragm muscle. Co-ordinated activity of thoracic pump and upper airway dilator muscles is required for optimal control of upper airway caliber. A mismatch in the force-generating capacity of the complementary muscle groups could have adverse consequences for the control of airway patency and respiratory homeostasis

Early Life Exposure to Chronic Intermittent Hypoxia Primes Increased Susceptibility to Hypoxia-Induced Weakness in Rat Sternohyoid Muscle during Adulthood

Intermittent hypoxia is a feature of apnea of prematurity (AOP), chronic lung disease, and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH) during postnatal development (pCIH) causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 h of delivery, pups and their respective dams were exposed to CIH: 90 s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 h per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH), where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm) weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life

The Discovery of an Active Galactic Nucleus in the Late-type Galaxy NGC 3621: Spitzer Spectroscopic Observations

We report the discovery of an Active Galactic Nucleus (AGN) in the nearby SAd galaxy NGC 3621 using Spitzer high spectral resolution observations. These observations reveal the presence of [NeV] 14 um and 24 um emission which is centrally concentrated and peaks at the position of the near-infrared nucleus. Using the [NeV] line luminosity, we estimate that the nuclear bolometric luminosity of the AGN is ~ 5 X 10^41 ergs s^-1, which corresponds based on the Eddington limit to a lower mass limit of the black hole of ~ 4 X 10^3 Msun. Using an order of magnitude estimate for the bulge mass based on the Hubble type of the galaxy, we find that this lower mass limit does not put a strain on the well-known relationship between the black hole mass and the host galaxy's stellar velocity dispersion established in predominantly early-type galaxies. Mutli-wavelength follow-up observations of NGC 3621 are required to obtain more precise estimates of the bulge mass, black hole mass, accretion rate, and nuclear bolometric luminosity. The discovery reported here adds to the growing evidence that a black hole can form and grow in a galaxy with no or minimal bulge.Comment: 5 pages, 7 figures, Accepted for publication in ApJ Letter