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Mass casualty events: what to do as the dust settles?
Care during mass casualty events (MCE) has improved during the last 15 years. Military and civilian collaboration has led to partnerships which augment the response to MCE. Much has been written about strategies to deliver care during an MCE, but there is little about how to transition back to normal operations after an event. A panel discussion entitled The Day(s) After: Lessons Learned from Trauma Team Management in the Aftermath of an Unexpected Mass Casualty Event at the 76th Annual American Association for the Surgery of Trauma meeting on September 13, 2017 brought together a cadre of military and civilian surgeons with experience in MCEs. The events described were the First Battle of Mogadishu (1993), the Second Battle of Fallujah (2004), the Bagram Detention Center Rocket Attack (2014), the Boston Marathon Bombing (2013), the Asiana Flight 214 Plane Crash (2013), the Baltimore Riots (2015), and the Orlando Pulse Night Club Shooting (2016). This article focuses on the lessons learned from military and civilian surgeons in the days after MCEs
Warming Up Density Functional Theory
Density functional theory (DFT) has become the most popular approach to
electronic structure across disciplines, especially in material and chemical
sciences. Last year, at least 30,000 papers used DFT to make useful predictions
or give insight into an enormous diversity of scientific problems, ranging from
battery development to solar cell efficiency and far beyond. The success of
this field has been driven by usefully accurate approximations based on known
exact conditions and careful testing and validation. In the last decade,
applications of DFT in a new area, warm dense matter, have exploded. DFT is
revolutionizing simulations of warm dense matter including applications in
controlled fusion, planetary interiors, and other areas of high energy density
physics. Over the past decade or so, molecular dynamics calculations driven by
modern density functional theory have played a crucial role in bringing
chemical realism to these applications, often (but not always) with excellent
agreement with experiment. This chapter summarizes recent work from our group
on density functional theory at non-zero temperatures, which we call thermal
DFT. We explain the relevance of this work in the context of warm dense matter,
and the importance of quantum chemistry to this regime. We illustrate many
basic concepts on a simple model system, the asymmetric Hubbard dimer
Calculation of a Deuterium Double Shock Hugoniot from Ab initio Simulations
We calculate the equation of state of dense deuterium with two ab initio
simulations techniques, path integral Monte Carlo and density functional theory
molecular dynamics, in the density range of 0.67 < rho < 1.60 g/cc. We derive
the double shock Hugoniot and compare with the recent laser-driven double shock
wave experiments by Mostovych et al. [1]. We find excellent agreement between
the two types of microscopic simulations but a significant discrepancy with the
laser-driven shock measurements.Comment: accept for publication in Phys. Rev. Lett., Nov. 2001, 4 pages, 4
figure
Hydrogen-Helium Mixtures at High Pressure
The properties of hydrogen-helium mixtures at high pressure are crucial to
address important questions about the interior of Giant planets e.g. whether
Jupiter has a rocky core and did it emerge via core accretion? Using path
integral Monte Carlo simulations, we study the properties of these mixtures as
a function of temperature, density and composition. The equation of state is
calculated and compared to chemical models. We probe the accuracy of the ideal
mixing approximation commonly used in such models. Finally, we discuss the
structure of the liquid in terms of pair correlation functions.Comment: Proceedings article of the 5th Conference on Cryocrystals and Quantum
Crystals in Wroclaw, Poland, submitted to J. Low. Temp. Phys. (2004
The Equation of State and the Hugoniot of Laser Shock-Compressed Deuterium
The equation of state and the shock Hugoniot of deuterium are calculated
using a first-principles approach, for the conditions of the recent shock
experiments. We use density functional theory within a classical mapping of the
quantum fluids [ Phys. Rev. Letters, {\bf 84}, 959 (2000) ]. The calculated
Hugoniot is close to the Path-Integral Monte Carlo (PIMC) result. We also
consider the {\it quasi-equilibrium} two-temperature case where the Deuterons
are hotter than the electrons; the resulting quasi-equilibrium Hugoniot mimics
the laser-shock data. The increased compressibility arises from hot
pairs occuring close to the zero of the electron chemical potential.Comment: Four pages; One Revtex manuscript, two postscipt figures; submitted
to PR
Accumulation of driver and passenger mutations during tumor progression
Major efforts to sequence cancer genomes are now occurring throughout the
world. Though the emerging data from these studies are illuminating, their
reconciliation with epidemiologic and clinical observations poses a major
challenge. In the current study, we provide a novel mathematical model that
begins to address this challenge. We model tumors as a discrete time branching
process that starts with a single driver mutation and proceeds as each new
driver mutation leads to a slightly increased rate of clonal expansion. Using
the model, we observe tremendous variation in the rate of tumor development -
providing an understanding of the heterogeneity in tumor sizes and development
times that have been observed by epidemiologists and clinicians. Furthermore,
the model provides a simple formula for the number of driver mutations as a
function of the total number of mutations in the tumor. Finally, when applied
to recent experimental data, the model allows us to calculate, for the first
time, the actual selective advantage provided by typical somatic mutations in
human tumors in situ. This selective advantage is surprisingly small, 0.005 +-
0.0005, and has major implications for experimental cancer research
The (p,n) Reaction at Intermediate Energies with the Isotopes of Oxygen (16-O, 17-O, 18-O) and 9-Be as Part of a Unified Approach to the Study of These Nuclei
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
The (p,n) Reaction at Intermediate Energies With the Isotopes of Oxygen (16-O, 17-O, 18-O) and 9-Be as Part of a Unified Approach to the Study of These Nuclei
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
Parity Violation in Neutron Resonances in 107,109Ag
Parity nonconservation (PNC) was studied in p-wave resonances in Ag by measuring the helicity dependence of the neutron total cross section. Transmission measurements on natural Ag were performed in the energy range 32 to 422 eV with the time-of-flight method at the Manuel Lujan Neutron Scattering Center at Los Alamos National Laboratory. A total of 15 p-wave neutron resonances were studied in 107Ag and ninep-wave resonances in 109Ag. Statistically significant asymmetries were observed for eight resonances in 107Ag and for four resonances in109Ag. An analysis treating the PNC matrix elements as random variables yields a weak spreading width of Γw=(2.67-1.21+2.65)×10-7 eV for107Ag and Γw=(1.30-0.74+2.49)×10-7 eV for 109Ag
Differential cross sections for pion charge exchange on the proton at 27.5 MeV
We have measured pion single charge exchange differential cross sections on
the proton at 27.5 MeV incident kinetic energy in the center of
momentum angular range between and . The extracted cross
sections are compared with predictions of the standard pion-nucleon partial
wave analysis and found to be in excellent agreement.Comment: ReVTeX v3.0 with aps.sty, 23 pages in e-print format, 7 PostScript
Figures and 4 Tables, also available via anonymous ftp at
ftp://helena.phys.virginia.edu/pub/preprints/scx.p
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