Christianity

This terse analysis of Christianity may help to provide a basis for understanding its true meaning and application. The authentic and foundational texts of 1 Corinthians 2:16, and Philippians 2:5 as well as Biblical Christian marriages are used here as exemplars that illustrate the definitive elements of the phenomena and its practice

Language Sophistication in the New Testament

Language sophistication indicates the development of language that incorporates differentiation or diversity that is constrained by integration that facilitates organization or unity. This prelude provides the backdrop for discussing language sophistication. Of necessity, any language that was a part of the continuum of salvation history (Heilsgeschichte ) should: 1) possess the sophistication necessary to re-define OT terminology, 2) have the hegemony to launch the NT church, 3) enjoy the universality that allowed for translation into contemporary languages, and 4) retain the portability that enables interpretation in post-modern languages

Linguistic Relativity in the New Testament

This is a three part discussion on linguistic relativity and the New Testament which provides some perspectives towards understanding the inter-relatedness of society, culture, and language as they would have impacted the writers of the New Testament. The ideas discussed should provide useful information for further research into the application of modern linguistics to New Testament hermeneutics, systematic theology, and biblical exegesis. The implications of linguistic relativity theory applied to this genre of literature are of extreme importance in light of resurgence in interest and work in biblical languages and modern linguistics in the last quarter of a century. The tripartite analysis focuses on: transcription of oral tradition, the influence of languages on the autographs, and the implications of linguistic relativity for exegesis

Revelation and Artificial Neural Networks

The grammatical forms and material of the book of Revelation suggest a complex interplay of Old Testament and 1st century literature and language. As well, the book does not lack its own peculiarity and character that is unparalleled in the literate world. Various analytical tools including historical-comparative methodologies have been employed to reconstruct the linguistic paradigm of the book. Artificial intelligence and its derivatives provide alternate methods of probing this paradigm

The challenge of evaluating pain and a pre-incisional local anesthetic block.

Background. Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX). Methods. This study is a prospective, randomized, blinded, clinical trial involving 59 healthy female dogs. An algometric pressure-measuring device was used to determine nociceptive threshold, and compared to three subjective pain scales. Group L/B received a line block of lidocaine (4 mg/kg) and bupivacaine (1 mg/kg) subcutaneously in the area of the incision site and saline subcutaneously as premedication; group L/BM (positive control) received a similar block and morphine (0.5 mg/kg) subcutaneously for premedication; and group SS (negative control) received a saline line block and saline premedication. Criteria for rescue analgesia were defined before the study. Dogs were assessed prior to surgery, at extubation (time 0) and at 2, 4, 6, 8 and 24 h post-recovery. The data were analyzed with one-way ANOVA, and a Split Plot Repeated Measures ANOVA with one grouping factor and one repeat factor (time). P < 0.05 was considered statistically significant. Results. Approximately 33% of dogs required rescue analgesia at some point during the study, with no significant difference between groups. There was no significant difference between treatment groups with any assessment method. Conclusions. As there were no statistically significant differences between positive and negative controls, the outcome of this technique cannot be proven

New Testament Oral Tradition: Problems in the Transcription

For the NT writer, transcription was the process of recording the Christological/theological events of their time to papyrus or vellum. The effort here is to help the reader to understand that from the spoken word to papyrus/vellum was not dictation or a simple copy process but rather a very arduous procedure that was subject to practices of oral expression and limited by the orthography of the target or writing language. Writers were not simply copying but they were re-interpreting oral traditions for the purpose of making a literary recording

Hellenism and Antisemitism in the New Testament

The New Testament Writings and the Septuagint were possibly compiled in Hellenism’s greatest period of influence. It is reasonable to say that the writings were influenced by Hellenism because they were written in the language of Hellenism. This study examines how the hegemony of Hellenism, the worldviews of Hellenists, and the current of anti-Semitism impacted the New Testament Writers and influenced why they wrote how they wrote

Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function

BACKGROUND: Monocytes/macrophages are likely key cells in immune modulation in dogs with osteosarcoma (OSA). Increased peripheral monocyte counts are negatively correlated with shorter disease-free intervals in dogs with OSA. Understanding the monocyte/macrophage's modulatory role in dogs with OSA can direct further studies in immunotherapy development for OSA. HYPOTHESIS/OBJECTIVES: That OSA evades the immune response by down-regulating monocyte chemokine receptor expression and migratory function, and suppresses host immune responses. ANIMALS: Eighteen dogs with OSA that have not received definitive treatment and 14 healthy age-matched controls METHODS: Clinical study-expression of peripheral blood monocyte cell surface receptors, monocyte mRNA expression and cytokine secretion, monocyte chemotaxis, and survival were compared between clinical dogs with OSA and healthy control dogs. RESULTS: Cell surface expression of multiple chemokine receptors is significantly down-regulated in peripheral blood monocytes of dogs with OSA. The percentage expression of CCR2 (median 58%, range 2-94%) and CXCR2 expression (median 54%, range 2-92%) was higher in control dogs compared to dogs with OSA (CCR2 median 29%, range 3-45%, P = 0.0006; CXCR2 median 23%, range 0.2-52%, P = 0.0007). Prostaglandin E2 (PGE2 ) (OSA, median 347.36 pg/mL, range 103.4-1268.5; control, 136.23 pg/mL, range 69.93-542.6, P = .04) and tumor necrosis factor-alpha (TNF-α) (P = .02) levels are increased in OSA monocyte culture supernatants compared to controls. Peripheral blood monocytes of dogs with OSA exhibit decreased chemotactic function when compared to control dogs (OSA, median 1.2 directed to random migration, range 0.8-1.25; control, 1.6, range of 0.9-1.8, P = .018). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with OSA have decreased monocyte chemokine receptor expression and monocyte chemotaxis, potential mechanisms by which OSA might evade the immune response. Reversal of monocyte dysfunction using immunotherapy could improve survival in dogs with OSA

Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study

Though controversial, onychectomy remains a commonly performed distal thoracic limb surgical procedure in cats. Peripheral nerve block techniques have been proposed in cats undergoing onychectomy but evidence of efficacy is lacking. Preliminary tests of the described technique using cadavers resulted in incomplete staining of nerves. The aim of this study was to develop nerve block methods based on cadaveric dissections and test these methods with cadaveric dye injections

A Feline-Specific Anti-Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease-Associated Pain: A Pilot Proof of Concept Study

BACKGROUND: Neutralizing antibodies against nerve growth factor (NGF) are analgesic in rodent models, naturally occurring degenerative joint disease (DJD) pain in dogs, and chronic pain in humans. OBJECTIVES: To evaluate the efficacy of a fully felinized anti-NGF antibody (NV-02) for the treatment of DJD pain and mobility impairment in cats. ANIMALS: Thirty-four client-owned cats with DJD-associated pain and mobility impairment. METHODS: In a placebo-controlled, pilot, masked clinical study, cats were randomized to a single treatment with NV-02 (0.4 mg/kg SC [n = 11] or 0.8 mg/kg SC [n = 12]) or placebo (saline, SC [n = 11]). Activity was measured objectively. Additionally, owners completed clinical metrology instruments (client-specific outcome measures [CSOM] and feline musculoskeletal pain index [FMPI]) on days 0 (screening), 14 (baseline), 35, 56, and 77. A repeated-measures model was used to evaluate the objective activity data. RESULTS: NV-02 significantly increased objectively measured activity overall (P = .017) and at 2 (P = .035), 3 (P = .007), 4 (P = .006), 5 (P = .007), and 6 (P = .017) weeks after treatment. CSOM scores (P = .035) and pain (P = .024) showed a significant effect of treatment 3 weeks after administration. In the treatment group, 83% of the owners correctly identified the treatment administered compared with 45% of owners in the placebo group (P = .013). No treatment-related adverse effects were identified. CONCLUSIONS: These pilot data demonstrate a 6-week duration positive analgesic effect of this fully felinized anti-NGF antibody in cats suffering from DJD-associated pain