TB25: The Effect of Stand Factors on the Productivity of Wheeled Skidders in Eastern Maine

The objective of this study was to determine what forest stand factors, as they constitute a set of operating conditions, affect skidder and skidder crew productivity and the degree of their effect.https://digitalcommons.library.umaine.edu/aes_techbulletin/1164/thumbnail.jp

B640: An Evaluation of the Distribution of Trucked Pulpwood in East-Central Maine

The movement of pulpwood from forest to market can be a critical and costly activity. Many factors influence this movement and contribute to its complexity. In 1963, a study was undertaken to quantitatively describe the distribution patterns of trucked pulpwood for a representative area of the state of Maine.https://digitalcommons.library.umaine.edu/aes_bulletin/1074/thumbnail.jp

Design of automatic milking system for use in pasture-based systems

End of Project ReportA commercial vision system was successful in identifying target artificial teats in various and demanding scenarios, but the system is very prone to making false identifications. A robotic manipulator capable of the simultaneous handling of four milking cups has been designed. The end-effector profile is sufficiently compact to allow access between the rear legs of the cow while enabling full access to all four teats for application of milking cups. The positioning response of the end-effecter is satisfactory for accommodating small changes in teat position during milking cup application

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease

Dislocation Emission around Nanoindentations on a (001) fcc Metal Surface Studied by STM and Atomistic Simulations

We present a combined study by Scanning Tunneling Microscopy and atomistic simulations of the emission of dissociated dislocation loops by nanoindentation on a (001) fcc surface. The latter consist of two stacking-fault ribbons bounded by Shockley partials and a stair-rod dislocation. These dissociated loops, which intersect the surface, are shown to originate from loops of interstitial character emitted along the directions and are usually located at hundreds of angstroms away from the indentation point. Simulations reproduce the nucleation and glide of these dislocation loops.Comment: 10 pages, 4 figure