Transport phenomenology for a holon-spinon fluid

We propose that the normal-state transport in the cuprate superconductors can be understood in terms of a two-fluid model of spinons and holons. In our scenario, the resistivity is determined by the properties of the holons while magnetotransport involves the recombination of holons and spinons to form physical electrons. Our model implies that the Hall transport time is a measure of the electron lifetime, which is shorter than the longitudinal transport time. This agrees with our analysis of the normal-state data. We predict a strong increase in linewidth with increasing temperature in photoemission. Our model also suggests that the AC Hall effect is controlled by the transport time.Comment: 4 pages, 1 postscript figure. Uses RevTeX, epsf, multico

Scaling regimes and critical dimensions in the Kardar-Parisi-Zhang problem

We study the scaling regimes for the Kardar-Parisi-Zhang equation with noise correlator R(q) ~ (1 + w q^{-2 \rho}) in Fourier space, as a function of \rho and the spatial dimension d. By means of a stochastic Cole-Hopf transformation, the critical and correction-to-scaling exponents at the roughening transition are determined to all orders in a (d - d_c) expansion. We also argue that there is a intriguing possibility that the rough phases above and below the lower critical dimension d_c = 2 (1 + \rho) are genuinely different which could lead to a re-interpretation of results in the literature.Comment: Latex, 7 pages, eps files for two figures as well as Europhys. Lett. style files included; slightly expanded reincarnatio

Soliton Resonances for MKP-II

Using the second flow - the Derivative Reaction-Diffusion system, and the third one of the dissipative SL(2,R) Kaup-Newell hierarchy, we show that the product of two functions, satisfying those systems is a solution of the modified Kadomtsev-Petviashvili equation in 2+1 dimension with negative dispersion (MKP-II). We construct Hirota's bilinear representation for both flows and combine them together as the bilinear system for MKP-II. Using this bilinear form we find one and two soliton solutions for the MKP-II. For special values of parameters our solution shows resonance behaviour with creation of four virtual solitons. Our approach allows one to interpret the resonance soliton as a composite object of two dissipative solitons in 1+1 dimensions.Comment: 11 pages, 2 figures, Talk on International Conference "Nonlinear Physics. Theory and Experiment. III", 24 June-3 July, 2004, Gallipoli(Lecce), Ital

Self-dual Maxwell Chern-Simons Solitons In 1+1 Dimensions

We study the domain wall soliton solutions in the relativistic self-dual Maxwell Chern-Simons model in 1+1 dimensions obtained by the dimensional reduction of the 2+1 model. Both topological and nontopological self-dual solutions are found in this case. A la BPS dyons here the Bogomol'ny bound on the energy is expressed in terms of two conserved quantities. We discuss the underlying supersymmetry. Nonrelativistic limit of this model is also considered and static, nonrelativistic self-dual soliton solutions are obtained.Comment: 18 pages RevTex, 2 figures included, to appear in Phys. Rev.

Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

Peptide deformylase (PDF) catalyzes the removal of the formyl group from the N-terminal methionine residue in newly synthesized polypeptides, which is an essential process in bacteria. Four new inhibitors of PDF that belong to two different classes, hydroxamate/pseudopeptide compounds [PMT387 (7a) and PMT497] and reverse-hydroxamate/nonpeptide compounds [PMT1039 (15e) and PMT1067], have been developed. These compounds inhibited the growth of several pathogens involved in respiratory-tract infections, such as Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae, and leading nosocomial pathogens such as Staphylococcus aureus and Klebsiella pneumoniae with a minimum inhibitory concentration (MIC) in the range 0.1-0.8 mg ml(-1). Interestingly, the reverse-hydroxamate/nonpeptide compounds showed a 250-fold higher antimicrobial activity towards S. aureus, although the four compounds showed similar K-i values against S. aureus PDF enzymes, with Ki values in the 11-85 nM range. To provide a structural basis for the discovery of additional PDF inhibitors, the crystal structures of S. aureus PDF in complex with the four inhibitors were determined at resolutions of 1.90-2.30 angstrom. The inhibitor-bound structures displayed distinct deviations depending on the inhibitor class. The distance between the Zn2+ ion and the carbonyl O atom of the hydroxamate inhibitors (or the hydroxyl O atom of the reverse-hydroxamate inhibitors) appears to be correlated to S. aureus inhibition activity. The structural information reported in this study should aid in the discovery of new PDF inhibitors that can be used as novel antibacterial drugs