Refining the isotopic (Sr-Nd) signature of potential source areas for glacial dust in East Antarctica

The geographical origin of the mineral dust transported to the East Antarctic Plateau from the Southern Hemisphere (SH) continents has been investigated by means of the isotopic (Sr-Nd) signature of samples from Potential Source Areas (PSAs). Dust reaching Antarctica is fine-grained ($<$5 $\mu$um), and therefore the new isotopic fields have been defined in the equivalent size range. The so obtained dataset evidences a partial overlap among the signatures of the Ice Cote dust and South America, New Zealand and the Antarctic Dry Valleys, while South Africa appear distinctly different: further data are needed for the Australian continent Despite the geochemical similarity with the Dry Valleys and New Zealand, Southern South America still appears to be the most probable source for dust in Antarctica in glacial times.

Hypersensitivity to platinum salts according to BRCA status in ovarian cancer: A retrospective analysis of clinical outcomes and systematic review of literature.

Hypersensitivity reactions (HSRs) to platinum are an important issue in the treatment of patients (pts) with ovarian cancer (OC). Germline BRCA mutations have been proposed as a risk factor. We aimed at evaluating the incidence and severity of HSRs to platinum in OC pts. with known BRCA status. We retrospectively analyzed 432 pts. from 5 Italian Centers. In addition, we performed a systematic review and meta-analysis of published series. Four hundred nine pts. received at least one prior platinum-based treatment line: 314 were BRCA wild type (77%) and 95 were BRCA mutated (23%). There was no statistical difference in exposure to platinum. Incidence of any grade HSRs was higher among BRCA mutated pts. [9% vs 18%, p = 0.019] and the time-to-HSRs curves show that the risk increases with the duration of platinum exposure, in BRCA mutated pts. more than in BRCA wild type. A multivariable analysis showed that harboring a germline BRCA mutation was related to a higher incidence of HSRs (HR: 1.84, 95% CI 1.00-3.99, p = 0.05) while having received pegylated liposomal doxorubicin (PLD) was related to a lower incidence of HSRs (HR: 0.03 95% CI 0.004-0.22, p = 0.001). The systematic review confirmed the higher incidence of HSRs in BRCA mutated pts., though heterogeneity among series was significant. In OC pts. with BRCA mutations, there is a significantly higher incidence of HSRs to carboplatin, not justified by longer drug exposure. On the other hand, PLD exerted a protective role in our series

Percorsi creativi di turismo urbano Creative paths of urban tourism I luoghi dell'entertainment nella citt\ue0 del tempo libero

Le specializzazioni funzionali, con mirati interventi di riqualificazione, spesso modificano gli impianti urbani esistenti per destinarli allo svago, alle attivit\ue0 ludiche, ai luoghi della cosiddetta \u201cutopia d\u2019evasione\u201d. Shopping, movida, sport, benessere, parchi urbani, spiagge urbane, acquari e parchi acquatici, bio-zoo, lunapark, water-front sono vere e proprie macchine per il divertimento dove spesso l\u2019artificiale diviene un richiamo irresistibile. Tali tendenze comportano spesso l\u2019innesco di processi di Disneyficazione dei luoghi, un fenomeno complesso con aspetti contrastanti che vanno considerati ed indagati non solo dal punto di vista strettamente turistico ma anche sociale e territoriale. Infatti il linguaggio delle immagini generato dal racconto iconografico delle cartoline, delle foto e oggi da quello narrativo del cinema e delle fiction ha alimentato la diffusione della cultura visuale della citt\ue0. Cos\uec come la Kodakizzazione che genera curiosit\ue0 e interesse per i luoghi producendo spesso delle mappe esperienziali. L\u2019immagine urbana ha da sempre risentito dello sguardo dei cineasti. Al cinema si \ue8 aggiunta oggi la proliferazione delle fiction e serie tv (per es. Don Matteo, Elisa di Rivombrosa, il Commissario Montalbano) con ritorni sorprendenti sotto il profilo delle presenze turistiche. Si tratta di una nuova El Dorado o ancora di illusioni di sviluppo per i territori