Syringomatous carcinoma: Case report of a rare tumor entity

Syringomatous carcinoma is a rare cutaneous neoplasm, most frequently situated on the face and scalp and histologically characterised by aninfiltrative pattern of basaloid or squamous cells, a desmoplastic stromal reaction and keratin filled cysts. We report the case of a 76-year-oldwoman who presented an ulcerative interscapular lesion measuring 3x4cm. After resection, the histological examinations of the specimens haveidentified a basal cell carcinoma. However, a local recurrence was observed 18 months later; histopathological findings showed a syringomatouspattern and neoplastic epithelial cells arranged in interconnecting cords with microcystic areas. Nests, cords, and tubules of the tumour extendedinto the dermis and into the adjacent muscle. Sclerosis of stroma around the cords was present. Tumour cells were not connected to the epidermis. The immunohistochemical analysis showed positivity for anti-CK7, AE1/AE3 and negativity for anti CEA and anti CK20. These histological and immunohistochemical analyses were consistent with the diagnosis of syringomatous eccrine carcinoma. Syringomatous carcinoma is an extremely invasive tumor, locally destructive and slowly growing adnexal tumour, derived from eccrine sweat glands. It is often mistaken, both clinically and microscopically, for other benign and malignant entities. The tumour recurrence is high due to extensive perineural invasion, butregional or distant metastases are rare. The local aggressive nature of the tumour and the high recurrence rate may necessitate mutilating procedures. Optimal treatment consists of a complete microscopically controlled surgical excision with clear surgical margins. Key words: Syringomatous carcinoma, histopathology, immunohistochemistry, differential diagnosi

Primary non-Hodgkin’s lymphoma of the bladder: case report and literature review

Primary non-Hodgkin's lymphoma (NHL) of the bladder is a very rare entity. The clinical, radiological and endoscopic signs are not specifics. The diagnosis is exclusively histological. Chemotherapy, radiotherapy and surgery are the different therapeutic options used either alone or in combination. We report a 57 years old patient treated with chemotherapy (6 cycles of R-CHOP) for primary NHL of the bladder with a complete response while discussing the different specificities of this disease.Key words: Primary lymphoma, Non-Hodgkin’s lymphoma, Bladder, Chemotherap

Current Opinion and Practice on Peritoneal Carcinomatosis Management: The North African Perspective.

The status of peritoneal surface malignancy (PSM) management in North Africa is undetermined. The aim of this study was to assess and compare current practice and knowledge regarding PSM and examine satisfaction with available treatment options and need for alternative therapies in North Africa. This is a qualitative study involving specialists participating in PSM management in North Africa. The survey analyzed demographic characteristics and current knowledge and opinions regarding PSM management in different institutions. We also looked at goals and priorities, satisfaction with treatment modalities and heated intraperitoneal chemotherapy (HIPEC) usefulness according to specialty, country, years of experience, and activity sector. One-hundred and three participants responded to the survey (response rate of 57%), including oncologists and surgeons. 59.2% of respondents had more than 10 years experience and 45.6% treated 20-50 PSM cases annually. Participants satisfaction with PSM treatment modalities was mild for gastric cancer (3/10 [IQR 2-3]) and moderate for colorectal (5/10 [IQR 3-5]), ovarian (5/10 [IQR 3-5]), and pseudomyxoma peritonei (5/10 [IQR 3-5]) type of malignancies. Good quality of life and symptom relief were rated as main priorities for treatment and the need for new treatment modalities was rated 9/10 [IQR 8-9]. The perceived usefulness of systemic chemotherapy in first intention was described as high by 42.7 and 39.8% of respondents for PSM of colorectal and gastric origins, while HIPEC was described as highly useful for ovarian (49.5%) and PMP (73.8) malignancies. The management of PSM in the North African region has distinct differences in knowledge, treatments availability and priorities. Disparities are also noted according to specialty, country, years of expertise, and activity sector. The creation of referral structures and PSM networks could be a step forward to standardized PSM management in the region

Invasive Lobular Carcinoma of the Breast with Extracellular Mucin: Case Report of a New Variant of Lobular Carcinoma of the Breast

Invasive carcinoma of no special type (NST) or ductal carcinoma is the largest group of invasive breast cancers. Invasive lobular carcinoma (ILC) is the second most common histological type; it comprises 5%–15% of all invasive breast cancers. Historically, lobular neoplasia and invasive lobular carcinoma may produce intracellular mucin that pushes the nucleus to one side, creating the characteristic signet ring cell morphology. The extracellular mucin secretion is essentially described in mucinous breast carcinoma. Mucinous differentiation can be seen in small areas of NST carcinoma, but recently a few cases of invasive lobular carcinoma with extracellular mucin are reported in the literature. It is important for pathologists to recognize this new entity because it mimics a NST carcinoma, as such a diagnosis may require a different approach in clinical management and surveillance. We report a new case of ILC with extracellular mucin and a review of the literature

Experimental investigation into the behaviour of continuous concrete beams reinforced with basalt FRP

The durability of reinforced concrete structures is an ongoing challenge for engineers, particularly in harsh environments such as industrial or marine settings. This paper is concerned with continuous concrete beams which are reinforced with basalt fibre reinforced polymer (BFRP) reinforcing bars, rather than traditional steel rebars, to improve the durability. Continuous concrete members are commonly used in bridges and carparks and therefore may be susceptible to corrosion by being a harsh environment or through exposure to de-icing salts. There are increasing levels of interest in structural solutions that offer durability as well as mechanical performance, and in this context, BFRP reinforcement can provide an effective, sustainable, and durable solution. This paper describes an experimental programme comprising four, two-span continuous reinforced concrete beams, containing BFRP rebars and stirrups. The test results are analysed in the paper, with particular focus given to the cracking behaviour, bending capacity, moment redistribution and deflections. The test results are compared with American and Canadian design codes. It is found that both design codes overestimate the cracking moment and sagging bending moment capacity but underestimate the deflections. Furthermore, this research found that BFRP RC continuous beams exhibited at least 20% moment redistribution. The findings from this research suggest that the RC continuous beams can be entirely reinforced with BFRP rebars and stirrups to achieve corrosion free concrete element

Experimental investigation into the behaviour of continuous concrete beams reinforced with basalt FRP

The durability of reinforced concrete structures is an ongoing challenge for engineers, particularly in harsh environments such as industrial or marine settings. This paper is concerned with continuous concrete beams which are reinforced with basalt fibre reinforced polymer (BFRP) reinforcing bars, rather than traditional steel rebars, to improve the durability. Continuous concrete members are commonly used in bridges and carparks and therefore may be susceptible to corrosion by being a harsh environment or through exposure to de-icing salts. There are increasing levels of interest in structural solutions that offer durability as well as mechanical performance, and in this context, BFRP reinforcement can provide an effective, sustainable, and durable solution. This paper describes an experimental programme comprising four, two-span continuous reinforced concrete beams, containing BFRP rebars and stirrups. The test results are analysed in the paper, with particular focus given to the cracking behaviour, bending capacity, moment redistribution and deflections. The test results are compared with American and Canadian design codes. It is found that both design codes overestimate the cracking moment and sagging bending moment capacity but underestimate the deflections. Furthermore, this research found that BFRP RC continuous beams exhibited at least 20% moment redistribution. The findings from this research suggest that the RC continuous beams can be entirely reinforced with BFRP rebars and stirrups to achieve corrosion free concrete element.UKRI Global Challenge Research Fund QR GCR