16 research outputs found

    Solar Orbiter observations of the structure of reconnection outflow layers in the solar wind

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    We briefly review an existing model of the structure of reconnection layers which predicts that several more distinct layers, in the form of contact discontinuities, rotational Alfvèn waves, or slow shocks, should be identifiable in solar wind reconnection events than are typically reported in studies of reconnection outflows associated with bifurcated current sheets. We re-examine this notion and recast the identification of such layers in terms of the changes associated with the boundaries of both the ion and electron outflows from the reconnection current layers. We then present a case study using Solar Orbiter MAG and SWA data, which provides evidence consistent with this picture of extended multiple layers around the bifurcated current sheet. A full confirmation of this picture requires more detailed examination of the particle distributions in this and other events. However, we believe this concept is a valuable framework for considering the nature of reconnection layers in the solar wind

    A Surface Enolase Participates in Borrelia burgdorferi-Plasminogen Interaction and Contributes to Pathogen Survival within Feeding Ticks

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    Borrelia burgdorferi, a tick-borne bacterial pathogen, causes a disseminated infection involving multiple organs known as Lyme disease. Surface proteins can directly participate in microbial virulence by facilitating pathogen dissemination via interaction with host factors. We show here that a fraction of the B. burgdorferi chromosomal gene product BB0337, annotated as enolase or phosphopyruvate dehydratase, is associated with spirochete outer membrane and is surface exposed. B. burgdorferi enolase, either in a recombinant form or as a membrane-bound native antigen, displays enzymatic activities intrinsic to the glycolytic pathway. However, the protein also interacts with host plasminogen, potentially leading to its activation and resulting in B. burgdorferi-induced fibrinolysis. As expected, enolase displayed consistent expression in vivo, however, with a variable temporal and spatial expression during spirochete infection in mice and ticks. Despite an extracellular exposure of the antigen and a potential role in host-pathogen interaction, active immunization of mice with recombinant enolase failed to evoke protective immunity against subsequent B. burgdorferi infection. In contrast, enolase immunization of murine hosts significantly reduced the acquisition of spirochetes by feeding ticks, suggesting that the protein could have a stage-specific role in B. burgdorferi survival in the feeding vector. Strategies to interfere with the function of surface enolase could contribute to the development of novel preventive measures to interrupt the spirochete infection cycle and reduce the incidences of Lyme disease
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