4 research outputs found
Common variants at 10 genomic loci influence hemoglobin Aâ(C) levels via glycemic and nonglycemic pathways.
- Author
- A. Bonnefond (7609472)
- A. Cao (6643043)
- A. Döring (7609562)
- A. F. Stewart (7608944)
- A. F. Wright (7609490)
- A. Goel (7602413)
- A. Greinacher (7609298)
- A. Hall (7131740)
- A. Hamsten (7602395)
- A. J. Swift (7609451)
- A. Jula (7609328)
- A. Kong (6907133)
- A. Köttgen (7609343)
- A. MĂ€larstig (7609382)
- A. Silveira (7609433)
- A. Teumer (7609454)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- B. Balkau (7609544)
- B. Böhm (5867516)
- B. F. Voight (7605833)
- B. KĂŒhnel (7609352)
- B. Wright (7609538)
- C. Franklin (7609283)
- C. Gieger (7609259)
- C. Hayward (7609304)
- C. Herder (3531713)
- C. Langenberg (7608872)
- C. Lecoeur (7609361)
- C. Meisinger (3995486)
- C. O'Donnell (7609556)
- C. S. Fox (7609280)
- C. W. Knouff (7609337)
- C. Willenborg (7605947)
- C. Zabena (7609499)
- D. Altshuler (7606010)
- D. Arking (7609541)
- D. Barnes (775647)
- D. Hadley (7609301)
- D. I. Boomsma (1812745)
- D. J. Rader (7605215)
- D. M. Nathan (7609418)
- D. M. Waterworth (7609469)
- D. P. Strachan (3809152)
- D. Radke (7609262)
- D. Schlessinger (7609430)
- D. Siscovick (7605995)
- E. Boerwinkle (7609103)
- E. J. de Geus (7609535)
- E. Porcu (3354512)
- E. Selvin (7609373)
- E. Stolerman (7609268)
- E. Wheeler (4607599)
- F. Payne (7609349)
- F. S. Collins (7609505)
- G. Abecasis (7609514)
- G. H. Williams (7609481)
- G. Homuth (7609310)
- G. Rocheleau (7609364)
- G. Thorleifsson (7606022)
- G. Usala (7609460)
- G. Willemsen (7609478)
- H. Campbell (7609436)
- H. E. Wichmann (7608932)
- H. Grallert (4107469)
- H. H. Hakonarson (7609502)
- H. Schunkert (7603670)
- H. Völzke (6643736)
- H. Wallaschofski (7609466)
- H. Watkins (7602419)
- I. Barroso (7609532)
- I. Prokopenko (7608875)
- I. Rudan (7609409)
- I. Surakka (7606076)
- J. B. Meigs (7608965)
- J. C. Florez (7608869)
- J. Chambers (3846385)
- J. Coresh (7609520)
- J. Dupuis (7608866)
- J. Erdmann (7603664)
- J. F. Peden (7602416)
- J. F. Wilson (7605311)
- J. Graessler (7609292)
- J. H. Zhao (1395031)
- J. J. Hottenga (7609313)
- J. Kooner (7609340)
- J. Kuusisto (7609355)
- J. Luan (7609367)
- J. M. Devaney (7609289)
- J. M. Egan (7608917)
- J. S. Pankow (7609316)
- J. Winkelmann (7609487)
- K Stefansson (7609439)
- K. Krohn (2494780)
- K. L. Mohlke (7605866)
- K. Oexle (7609274)
- K. Song (7608860)
- K. T. Khaw (7609508)
- L. Ferrucci (7608902)
- L. Groop (7609070)
- L. L. Bonnycastle (7609496)
- L. Peltonen (7606004)
- M. A. Morken (7609412)
- M. Boehnke (7605344)
- M. D. Fleming (7609511)
- M. Dei (7609559)
- M. G. Franzosi (7602410)
- M. I. McCarthy (7609121)
- M. Kleber (7609331)
- M. Laakso (7609358)
- M. Lathrop (7602425)
- M. Li (621494)
- M. M. Heeney (7609427)
- M. Mangino (7609385)
- M. Nauck (6643733)
- M. P. Reilly (7605332)
- M. Perola (7605860)
- M. Roden (7609388)
- M. S. Burnett-Miller (7609553)
- M. S. Sandhu (7609271)
- M. Serrano-RĂos (7609400)
- M. Stumvoll (7609448)
- M. T. MartĂnez-Larrad (7609391)
- M. Uda (7609529)
- N. Bouatia-Naji (7609265)
- N. Forouhi (7609277)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. L. Pedersen (7609403)
- N. Narisu (7609415)
- N. Olla (7609295)
- N. Soranzo (7608857)
- O. Melander (7602683)
- O. Polasek (7609424)
- P. Deloukas (7603691)
- P. Froguel (7609517)
- P. K. Magnusson (7609379)
- P. Kovacs (7609346)
- P. Schwarz (7609334)
- P. Shrader (7609421)
- R. Clark (7609484)
- R. Elosua (7605998)
- R. Hunter-Merrill (7609319)
- R. J. Loos (7608845)
- R. McPherson (7605974)
- R. MĂ€gi (7609376)
- R. Roberts (2820928)
- R. Saxena (7608878)
- R. Sladek (7608881)
- R. Strawbridge (7609445)
- S. Bumpstead (7609550)
- S. E. Epstein (7606061)
- S. Gallina (7609286)
- S. H. Wild (7609475)
- S. Heath (7609307)
- S. Kathiresan (7606013)
- S. L. Ricketts (7608920)
- S. R. Bornstein (7609526)
- S. Ripatti (7606073)
- S. Sanna (7609256)
- T. D. Spector (7608968)
- T. Illig (7609322)
- T. Meitinger (14191)
- T. Tanaka (3979952)
- U. Seedorf (7602437)
- U. Thorsteinsdottir (7606031)
- V. E. Mooser (7609406)
- V. Lyssenko (7609370)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Vitart (7609463)
- W. H. Kao (7609523)
- W. L. McArdle (7609397)
- W. MĂ€rz (7609394)
- W. Rathmann (3531737)
- WTCCC (7609493)
- Y. Böttcher (7609547)
- Publication venue
- Publication date
- 01/12/2010
- Field of study
Glycated hemoglobin (HbAâ(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbAâ(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbAâ(c) levels
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
- Author
- A. A. Hicks (7626671)
- A. A. Sayer (7685645)
- A. B. Feranil (7685813)
- A. Bidulescu (7685318)
- A. Bonnefond (7609472)
- A. C. Edmondson (7609058)
- A. C. Fedson (7685588)
- A. C. Janssens (7670810)
- A. C. SyvÀnen (7626845)
- A. Cao (6643043)
- A. D. Hingorani (7602500)
- A. D. Morris (7611470)
- A. Dehghan (7626011)
- A. Doney (7685546)
- A. Döring (7609562)
- A. Elliott (7649519)
- A. F. Dominiczak (7602482)
- A. F. Pfeiffer (7685636)
- A. F. Wright (7609490)
- A. Fischer-Rosinsky (7685591)
- A. G. Uitterlinden (7611476)
- A. Goel (7602413)
- A. Hamsten (7602395)
- A. Hofman (4269889)
- A. Isaacs (7647437)
- A. J. Bennett (7611521)
- A. J. Swift (7609451)
- A. Jula (7609328)
- A. K. Manning (7652627)
- A. K. Petersen (7626545)
- A. Kanaya (7685360)
- A. Kong (6907133)
- A. L. Elliott (7685456)
- A. L. Gloyn (7685519)
- A. L. Hartikainen (7626647)
- A. Lieverse (7685474)
- A. N. Parker (7685774)
- A. P. Morris (7611419)
- A. Pouta (7650326)
- A. R. Shuldiner (7685708)
- A. R. Tall (7685822)
- A. R. Wood (7685348)
- A. Ruokonen (7611434)
- A. S. Doney (7611554)
- A. S. Hall (7605176)
- A. S. Havulinna (7611503)
- A. Sandbaek (7584560)
- A. Scuteri (7611440)
- A. Silveira (7609433)
- A. Singleton (7646228)
- A. Swift (7685660)
- A. T. Hattersley (7609073)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- A. Uitterlinden (7640531)
- A. V. SegrĂš (7607906)
- A. V. Smith (7605131)
- A. Walley (7685681)
- A. Ziegler (2721280)
- B. A. Oostra (7611425)
- B. B. Duncan (7685366)
- B. Balkau (7609544)
- B. Bravenboer (7685444)
- B. D. Mitchell (7685618)
- B. F. Voight (7605833)
- B. Isomaa (7611398)
- B. Knight (7685606)
- B. M. Loo (7685357)
- B. M. Psaty (7605224)
- B. M. Shields (7685492)
- B. O. Boehm (7660346)
- B. Paulweber (7685405)
- B. Shields (7685648)
- B. St Pourcain (7653158)
- B. Thorand (3531725)
- B. W. Penninx (7611212)
- B. Zethelius (82641)
- C. Cavalcanti-Proença (7685549)
- C. Cooper (3405176)
- C. Dina (7685408)
- C. Fuchsberger (7683191)
- C. Gieger (7609259)
- C. Guiducci (7605929)
- C. Hayward (7609304)
- C. Hengstenberg (7603694)
- C. Herder (3531713)
- C. Huth (7685414)
- C. J. Groves (7611536)
- C. J. O'Donnell (7605308)
- C. J. Willer (7611383)
- C. Lamina (7611263)
- C. Langenberg (7608872)
- C. Lecoeur (7609361)
- C. M. Ballantyne (7685402)
- C. M. Greenwood (7685321)
- C. M. Lindgren (7611374)
- C. M. van Duijn (7626872)
- C. Meisinger (3995486)
- C. N. Palmer (7611428)
- C. Pattaro (7670822)
- C. Platou (7685483)
- C. Proença (7685486)
- C. S. Fox (7609280)
- C. S. Franklin (7632863)
- C. Sabatti (7685765)
- C. T. Johansen (7685732)
- C. T. Liu (5340632)
- C. van Duijn (7640522)
- C. W. Kuzawa (7685816)
- C. Wijmenga (7605896)
- C. Zabena (7609499)
- D. A. Lawlor (2400574)
- D. A. Nickerson (7609136)
- D. Altshuler (7606010)
- D. C. Croteau-Chonka (7685753)
- D. I. Boomsma (1812745)
- D. I. Chasman (7605179)
- D. J. Couper (7643837)
- D. J. Hunter (7611488)
- D. J. Rader (7605215)
- D. M. Evans (7624460)
- D. M. Nathan (7609418)
- D. M. Waterworth (7609469)
- D. Masson (7685783)
- D. Melzer (7605218)
- D. Meyre (7685615)
- D. P. Strachan (3809152)
- D. Pearson (7685633)
- D. Posthuma (5044979)
- D. R. Hillman (7685603)
- D. Rybin (7685540)
- D. S. Siscovick (7611209)
- D. Schlessinger (7609430)
- D. van Heemst (7645163)
- D. Varma (7685669)
- D. Zelenika (7685690)
- DIAGRAM Consortium (7670852)
- DIAGRAM+ Consortium (7685375)
- E. Boerwinkle (7609103)
- E. Brunner (7611371)
- E. E. Schadt (7685831)
- E. G. Lakatta (7626938)
- E. Gonzalez (4991489)
- E. Ingelsson (7605335)
- E. J. de Geus (7609535)
- E. J. Sijbrands (7652312)
- E. Katsareli (7685363)
- E. S. Tai (7626848)
- E. Sijbrands (7685528)
- E. Wheeler (4607599)
- E. Zeggini (7632767)
- F. B. Hu (7611461)
- F. Karpe (7611410)
- F. Kronenberg (7611272)
- F. Marroni (7685786)
- F. Pattou (7685564)
- F. Payne (7609349)
- F. Rivadeneira (7611509)
- F. S. Collins (7609505)
- G. A. Hitman (7685525)
- G. B. Walters (7611446)
- G. Charpentier (7685447)
- G. Crawford (7611545)
- G. D. Smith (4912390)
- G. H. Williams (7609481)
- G. Hallmans (7626623)
- G. K. Hovingh (3801262)
- G. Lettre (7685792)
- G. Lucas (7606529)
- G. M. Lathrop (7611353)
- G. M. Peloso (7605836)
- G. Paolisso (7685630)
- G. Pare (7685777)
- G. R. Abecasis (7602524)
- G. Rocheleau (7609364)
- G. Sigurdsson (7685495)
- G. SigurĂ°sson (7685651)
- G. Thorleifsson (7606022)
- G. V. Dedoussis (7653293)
- G. W. Montgomery (7652342)
- G. Waeber (4002158)
- G. Willemsen (7609478)
- G. Wu (699565)
- G. Zhai (7685693)
- GIANT Consortium (7685696)
- GLGC Consortium (7685723)
- GLGC Investigators (7685381)
- Global B Pgen Consortium (7685699)
- H. A. Taylor (7685819)
- H. Campbell (7609436)
- H. E. Wichmann (7608932)
- H. Grallert (4107469)
- H. Holm (7605371)
- H. M. Stringham (7605209)
- H. Schunkert (7603670)
- H. Syddall (7685663)
- H. W. Uh (7645082)
- H. Watkins (7602419)
- I. B. Borecki (7685702)
- I. Barroso (7609532)
- I. Chen (7685342)
- I. M. Heid (7611266)
- I. M. Stylianou (7685726)
- I. Meulenbelt (7685399)
- I. N. Day (7611455)
- I. Pichler (7648376)
- I. Prokopenko (7608875)
- I. R. König (7608923)
- I. Rudan (7609409)
- I. Surakka (7606076)
- J. B. Borja (7685372)
- J. B. McAteer (7685612)
- J. B. Meigs (7608965)
- J. B. Richards (7608833)
- J. B. Whitfield (7612142)
- J. Brody (7685339)
- J. C. Bis (7625957)
- J. C. Florez (7608869)
- J. C. Witteman (7608896)
- J. Chambers (3846385)
- J. D. Smith (7685756)
- J. Delplanque (7685585)
- J. Dupuis (7608866)
- J. Erdmann (7603664)
- J. F. Peden (7602416)
- J. F. Wilson (7605311)
- J. G. Eriksson (7647449)
- J. G. Wilson (7609118)
- J. Graessler (7609292)
- J. Grimsby (7685327)
- J. H. Smit (7626827)
- J. H. Zhao (1395031)
- J. Hui (6291092)
- J. Hung (7605338)
- J. I. Rotter (7626935)
- J. J. Hottenga (7609313)
- J. J. Kastelein (7685828)
- J. Kaprio (7647446)
- J. Kooner (7609340)
- J. Kuusisto (7609355)
- J. Luan (7609367)
- J. M. Egan (7608917)
- J. M. Ordovas (7605923)
- J. O'Connell (7685555)
- J. P. Beilby (7685573)
- J. P. Pirruccello (7606028)
- J. R. Kizer (7685312)
- J. R. Perry (7608848)
- J. R. Thompson (6440546)
- J. Randall (7685537)
- J. S. Kooner (7605356)
- J. S. Pankow (7609316)
- J. Saharinen (7685762)
- J. Scott (4095031)
- J. Sinisalo (6254942)
- J. Spranger (7685705)
- J. Tichet (7602638)
- J. Tuomilehto (7611044)
- J. V. van Vliet-Ostaptchouk (7685513)
- J. Viikari (7685345)
- J. W. Yarnell (7685687)
- J. Witteman (7652321)
- J. Y. Lee (2305705)
- K. A. Kapur (7685330)
- K. Ardlie (7685432)
- K. B. Boström (7685441)
- K. Borch-Johnsen (7584566)
- K. G. Ejebe (7685807)
- K. Hveem (7626929)
- K. Kim (2516335)
- K. Kristiansson (7626782)
- K. L. Mohlke (7605866)
- K. L. Ward (7685684)
- K. Lohman (7643855)
- K. Midthjell (7685477)
- K. Musunuru (7606025)
- K. O. Kyvik (7639958)
- K. R. Owen (7685480)
- K. Rice (7640519)
- K. S. Elliott (7685453)
- K. Silander (7611416)
- K. Small (7633049)
- K. Song (7608860)
- K. Stefansson (7606001)
- K. Strassburger (7685501)
- K. T. Khaw (7609508)
- K. W. van Dijk (7685666)
- K. Willems-Vandijk (7685336)
- L. A. Cupples (7605977)
- L. A. Lange (7646105)
- L. C. Groop (7685801)
- L. Crisponi (7685582)
- L. D. Stein (7605137)
- L. Ferrucci (7608902)
- L. Groop (7609070)
- L. J. Coin (7685576)
- L. J. Launer (7643819)
- L. J. McCulloch (7685417)
- L. J. Palmer (7608638)
- L. J. Rasmussen-Torvik (7646174)
- L. J. Scott (7611437)
- L. Kedenko (7685354)
- L. L. Bonnycastle (7609496)
- L. Lind (7625984)
- L. M. Kaplan (7685795)
- L. M. Rose (7685768)
- L. P. LyytikÀinen (7626830)
- L. Peltonen (7606004)
- L. Qi (2057833)
- L. S. Adair (7626569)
- L. Simpson (7685654)
- M. A. Allison (7685393)
- M. A. Morken (7609412)
- M. A. Province (7685642)
- M. Barbalic (7605845)
- M. Beekman (7645079)
- M. Bochud (7611158)
- M. Boehnke (7605344)
- M. C. Zillikens (7611512)
- M. Cornelis (7685450)
- M. F. Feitosa (7685738)
- M. F. Hivert (7608842)
- M. G. Franzosi (7602410)
- M. Ganser (7685459)
- M. Garcia (7650347)
- M. Haun (7628735)
- M. I. McCarthy (7609121)
- M. J. Caulfield (7602383)
- M. J. Daly (7605926)
- M. J. Go (7685744)
- M. J. Neville (7652672)
- M. J. Sampson (7685489)
- M. Kaakinen (7626740)
- M. Kivimaki (7602458)
- M. Kloppenburg (7685369)
- M. Koseki (7685729)
- M. Kumari (7602503)
- M. KÀhönen (3495260)
- M. L. Lokki (7685789)
- M. L. Nuotio (7652288)
- M. Laakso (7609358)
- M. Ladouceur (7685324)
- M. Li (621494)
- M. Mangino (7609385)
- M. Marmot (7611368)
- M. Marre (7611293)
- M. N. Cooper (7685579)
- M. N. Weedon (7611449)
- M. O. Goodarzi (7626941)
- M. Orho-Melander (7605839)
- M. OrrĂč (7685624)
- M. P. Reilly (7605332)
- M. Perola (7605860)
- M. R. Erdos (7611389)
- M. R. Jarvelin (7611464)
- M. Rieder (7685771)
- M. Roden (7609388)
- M. S. Nieminen (7605854)
- M. S. Sandhu (7609271)
- M. Sandhu (7636817)
- M. Seielstad (7685810)
- M. Serrano-RĂos (7609400)
- M. Stumvoll (7609448)
- M. T. MartĂnez-Larrad (7609391)
- M. Uda (7609529)
- M. van Hoek (7685429)
- M. Walker (1291794)
- MAGIC Consortium (7685378)
- MAGIC investigators (7685720)
- MuTHER Consortium (7685384)
- N. Amin (7611452)
- N. B. Freimer (7685804)
- N. Bouatia-Naji (7609265)
- N. D. Hastie (7650311)
- N. G. Forouhi (7611395)
- N. G. Martin (7639949)
- N. Grarup (7627439)
- N. Hammond (7685597)
- N. Hassanali (7685465)
- N. J. Timpson (7608851)
- N. J. Wareham (7608962)
- N. Klopp (7611599)
- N. L. Glazer (7685534)
- N. L. Pedersen (7609403)
- N. L. Smith (7646216)
- N. Narisu (7609415)
- N. P. Burtt (7605932)
- N. R. Robertson (7647422)
- N. Sattar (7608890)
- N. Soranzo (7608857)
- N. Timpson (7685309)
- N. Vogelzangs (7685675)
- N. W. Rayner (7626794)
- Nilesh Jayantilal Samani (7629899)
- O. D. Carlson (7685351)
- O. Le Bacquer (7685609)
- O. M. Hofmann (7685426)
- O. Melander (7602683)
- O. Pedersen (7627493)
- O. Polasek (7609424)
- O. Raitakari (3495236)
- O. Rolandsson (7652735)
- P. An (7685552)
- P. B. Munroe (7602386)
- P. Barter (7608935)
- P. Chines (7611539)
- P. Deloukas (7603691)
- P. E. Slagboom (7645244)
- P. Elliott (1293702)
- P. Froguel (7609517)
- P. Galan (7645211)
- P. Henneman (5044997)
- P. J. Wagner (7685678)
- P. K. Magnusson (7609379)
- P. Kovacs (7609346)
- P. Kraft (7685471)
- P. M. Ridker (7605368)
- P. Meneton (7626773)
- P. Navarro (1693129)
- P. Nilsson (3701965)
- P. P. Pramstaller (7626770)
- P. R. Johnson (7685468)
- P. S. Chines (7626599)
- P. Scheet (7611473)
- P. Schwarz (7609334)
- P. Sethupathy (7685567)
- P. Shrader (7609421)
- P. Vollenweider (4002164)
- P. W. Franks (7605191)
- Procardis Consortium (7685711)
- Q. Sun (1373196)
- R. A. Hegele (7685825)
- R. A. Scott (2840021)
- R. Benediktsson (7685435)
- R. Blagieva (7685438)
- R. Clarke (7602407)
- R. Frants (7685333)
- R. Gwilliam (7685594)
- R. J. Loos (7608845)
- R. Laaksonen (7640441)
- R. Luben (3537284)
- R. M. Krauss (7626722)
- R. M. Roccasecca (7685561)
- R. M. van Dam (7685504)
- R. M. Watanabe (7685531)
- R. Mahley (7608938)
- R. McPherson (7605974)
- R. MĂ€gi (7609376)
- R. N. Bergman (7611524)
- R. P. Tracy (7605272)
- R. P. Welch (7685411)
- R. Pakyz (7685627)
- R. Roberts (2820928)
- R. Saxena (7608878)
- R. Semple (7685390)
- R. Sladek (7608881)
- R. T. Ong (7685750)
- R. Y. Zee (7685759)
- S. A. McCarroll (7685423)
- S. B. Gabriel (7609124)
- S. Bandinelli (7611518)
- S. Bergmann (7612121)
- S. Bumpstead (7609550)
- S. Böhringer (3171543)
- S. C. Heath (7685600)
- S. C. Potter (7685639)
- S. Cauchi (7685516)
- S. Coassin (7685315)
- S. Demissie (7605914)
- S. Ebrahim (7611557)
- S. G. Buxbaum (7685396)
- S. Griffin (3537278)
- S. Grundy (7608929)
- S. H. Wild (7609475)
- S. Hadjadj (7685462)
- S. Hercberg (4444465)
- S. J. Bumpstead (7611527)
- S. J. Sharp (7619756)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. Koskinen (4172086)
- S. L. Ricketts (7608920)
- S. M. Boekholdt (7611776)
- S. M. Willems (7647404)
- S. Mukherjee (1671667)
- S. Musani (7685387)
- S. Naitza (7685621)
- S. R. Bornstein (7609526)
- S. Raychaudhuri (7685420)
- S. Redline (7650362)
- S. Ripatti (7606073)
- S. Sanna (7609256)
- S. Visvikis-Siest (7685672)
- S. W. Fouchier (7685735)
- T. A. Buchanan (7685714)
- T. B. Harris (7605353)
- T. D. Spector (7608968)
- T. Ferreira (3480845)
- T. Green (7607897)
- T. Hansen (3919604)
- T. Haritunians (7685798)
- T. Harris (7640504)
- T. Illig (7609322)
- T. Johnson (7602368)
- T. JĂžrgensen (7627442)
- T. L. Assimes (7605317)
- T. Lajunen (7685543)
- T. Lauritzen (7584572)
- T. LehtimÀki (3495257)
- T. M. Frayling (7608959)
- T. M. Teslovich (7683197)
- T. Meitinger (14191)
- T. Park (7685747)
- T. Quertermous (7626788)
- T. SparsĂž (7685498)
- T. T. Valle (7685717)
- T. Tanaka (3979952)
- T. Tuomi (7611443)
- T. van Herpt (7685510)
- T. W. van Haeften (7685507)
- T. W. Winkler (7647401)
- T. Y. Wong (7626602)
- U. de Faire (7605206)
- U. Gyllensten (7612145)
- U. Seedorf (7602437)
- U. Sovio (7685657)
- U. Thorsteinsdottir (7606031)
- V. E. Mooser (7609406)
- V. Gudnason (7605347)
- V. Lyssenko (7609370)
- V. Mooser (7606070)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Vitart (7609463)
- W. A. Hide (7685522)
- W. H. Kao (7609523)
- W. Igl (7670837)
- W. McArdle (7685780)
- W. Rathmann (3531737)
- W. Zhang (820655)
- X. Guo (1820437)
- X. Han (3042561)
- X. Li (536560)
- X. Sim (7626824)
- X. Yuan (696093)
- Y. A. Kesaniemi (7608941)
- Y. Ariyurek (7685570)
- Y. Ben-Shlomo (7605296)
- Y. Böttcher (7609547)
- Y. D. Chen (5184422)
- Y. J. Kim (1781752)
- Y. Li (696089)
- Y. Liu (543492)
- Y. S. Aulchenko (7611497)
- Y. S. Cho (7685741)
- Y. Wu (1590877)
- Z. Dastani (7685306)
- Ă . Johansson (7670804)
- Publication venue
- Publication date
- 29/03/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (Pâ=â4.5Ă10(-8)-1.2Ă10(-43)). Using a novel method to combine data across ethnicities (Nâ=â4,232 African Americans, Nâ=â1,776 Asians, and Nâ=â29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (pâ=â4.3Ă10(-3), nâ=â22,044), increased triglycerides (pâ=â2.6Ă10(-14), nâ=â93,440), increased waist-to-hip ratio (pâ=â1.8Ă10(-5), nâ=â77,167), increased glucose two hours post oral glucose tolerance testing (pâ=â4.4Ă10(-3), nâ=â15,234), increased fasting insulin (pâ=â0.015, nâ=â48,238), but with lower in HDL-cholesterol concentrations (pâ=â4.5Ă10(-13), nâ=â96,748) and decreased BMI (pâ=â1.4Ă10(-4), nâ=â121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
- Author
- A. A. Hicks (7626671)
- A. B. Weder (7626893)
- A. C. Morrison (7625951)
- A. C. SyvÀnen (7626845)
- A. Chakravarti (7626947)
- A. D. Hingorani (7602500)
- A. D. Johnson (7626965)
- A. D. Morris (7611470)
- A. Döring (7609562)
- A. Evans (3523205)
- A. F. Dominiczak (7602482)
- A. Franco-Cereceda (7626800)
- A. G. Uitterlinden (7611476)
- A. Goel (7602413)
- A. H. Goodall (7591808)
- A. Hamsten (7602395)
- A. Hofman (4269889)
- A. J. Smith (7596068)
- A. J. Swift (7609451)
- A. K. Petersen (7626545)
- A. L. Hartikainen (7626647)
- A. Metspalu (7626776)
- A. Mulas (7626920)
- A. P. Morris (7611419)
- A. Parsa (7626662)
- A. Peters (6004598)
- A. Rasheed (7605908)
- A. S. Doney (7611554)
- A. S. Havulinna (7611503)
- A. StanÄĂĄkovĂĄ (7626836)
- A. Teumer (7609454)
- A. U. Jackson (7609325)
- A. V. Smith (7605131)
- A. V. Stanton (7602569)
- A. Vaez (7626863)
- A. Wagner (2985462)
- A. Wong (7602695)
- B. Balkau (7609544)
- B. F. Voight (7605833)
- B. Gigante (7606052)
- B. J. Keating (7609007)
- B. M. Psaty (7605224)
- B. O. Tayo (7626548)
- B. W. Penninx (7611212)
- C. A. Hsiung (7626683)
- C. A. McKenzie (7626767)
- C. D. Palmer (7626644)
- C. Fava (7611170)
- C. Hayward (7609304)
- C. Iribarren (7626692)
- C. J. Groves (7611536)
- C. J. O'Donnell (7605308)
- C. J. Willer (7611383)
- C. Langenberg (7608872)
- C. M. van Duijn (7626872)
- C. Menni (7611143)
- C. N. Palmer (7611428)
- C. Newton-Cheh (7602563)
- C. P. Cabrera (7626590)
- C. Y. Cheng (7626596)
- CHARGE-EchoGen Consortium (7626554)
- CHARGE-HF Consortium (7626557)
- D. Absher (7626566)
- D. Baldassarre (7626578)
- D. C. Rao (7626791)
- D. E. Arking (7626572)
- D. I. Boomsma (1812745)
- D. I. Chasman (7605179)
- D. Kuh (7602698)
- D. Levy (2689588)
- D. Saleheen (7605173)
- D. Shungin (7626677)
- D. Vaidya (7626869)
- E. Boerwinkle (7609103)
- E. Evangelou (7626641)
- E. G. Lakatta (7626938)
- E. Ingelsson (7605335)
- E. Kim (7626707)
- E. L. Salfati (7626854)
- E. M. Schmidt (7626536)
- E. Marouli (7626761)
- E. P. van Iperen (7626875)
- E. S. Tai (7626848)
- E. Theusch (7626926)
- E. Tremoli (7626857)
- F. Drenos (7602632)
- F. Gianfagna (7626896)
- F. Giulianini (7626902)
- F. Mach (7626755)
- F. Paccaud (7626620)
- F. Renström (7611431)
- F. S. Collins (7609505)
- G. B. Ehret (7626533)
- G. Bjornsdottir (7626587)
- G. C. Verwoert (7626881)
- G. Dedoussis (7626908)
- G. Delgado (7626614)
- G. Hallmans (7626623)
- G. K. Hovingh (3801262)
- G. Kolovou (7626710)
- G. Kosova (7626719)
- G. MĂŒller (3988166)
- G. Thorleifsson (7606022)
- H. E. Wichmann (7608932)
- H. Gao (2194147)
- H. J. Gierman (7626890)
- H. J. Westra (7626899)
- H. Lin (3462437)
- H. M. Kang (7626701)
- H. M. Stringham (7605209)
- H. S. Markus (7626758)
- H. Schunkert (7603670)
- H. Snieder (7611185)
- H. Warren (3523808)
- H. Watkins (7602419)
- I. Barroso (7609532)
- I. M. Nolte (3809176)
- I. NjĂžlstad (3531731)
- I. S. Chang (7626593)
- I. T. Lee (7626737)
- J. C. Bis (7625957)
- J. C. Chambers (7605185)
- J. D. Eicher (7626629)
- J. Dallongeville (7626611)
- J. Danesh (7605383)
- J. Erdmann (7603664)
- J. F. Felix (7625948)
- J. F. Wilson (7605311)
- J. FerriĂšres (7626650)
- J. GrĂ€Ăler (7626551)
- J. H. Smit (7626827)
- J. H. Zhao (1395031)
- J. Holmen (7626674)
- J. I. Rotter (7626935)
- J. J. Hottenga (7609313)
- J. Kuusisto (7609355)
- J. Lindström (3847444)
- J. Luan (7609367)
- J. M. Connell (7602551)
- J. N. Hirschhorn (7609139)
- J. Rossouw (7626806)
- J. S. Kooner (7605356)
- J. Saltevo (7626917)
- J. Saramies (7626809)
- J. Sundstrom (7605260)
- J. Tuomilehto (7611044)
- J. Virtamo (7626887)
- J. Y. Lee (2305705)
- J. Yao (1794466)
- K .H. Herzig (7626665)
- K. D. Taylor (7626905)
- K. E. Stirrups (7626839)
- K. Gertow (7626884)
- K. Hveem (7626929)
- K. K. Ong (7626608)
- K. Kristiansson (7626782)
- K. Kuulasmaa (3531734)
- K. KvalĂžy (7626728)
- K. L. Mohlke (7605866)
- K. M. Rice (7626797)
- K. Nikus (7626950)
- K. Stefansson (7606001)
- K. T. Khaw (7609508)
- K. V. Tarasov (7626851)
- K. W. Liang (7626743)
- K. Witkowska (7611563)
- L. A. Donnelly (7626539)
- L. Ferrucci (7608902)
- L. Folkersen (7626944)
- L. Franke (7602401)
- L. L. Bonnycastle (7609496)
- L. Lataniotis (7626962)
- L. Lin (2930919)
- L. Lind (7625984)
- L. Moilanen (7247441)
- L. P. LyytikÀinen (7626830)
- L. S. Adair (7626569)
- L. S. Rallidis (7626911)
- L. Yengo (7626668)
- LM Rose (7626803)
- Louise V. Wain (7588511)
- M. A. Ikram (7626689)
- M. Bochud (7611158)
- M. Boehnke (7605344)
- M. Burnier (7611161)
- M. D. Tobin (7602575)
- M. E. Kleber (7605227)
- M. E. Montasser (7626713)
- M. F. Hughes (7626698)
- M. Farrall (6522599)
- M. Fornage (7609064)
- M. Gorski (7626956)
- M. Hassinen (7626659)
- M. I. McCarthy (7609121)
- M. J. Brown (7602548)
- M. J. Caulfield (7602383)
- M. Kaakinen (7626740)
- M. Kivimaki (7602458)
- M. Kumari (7602503)
- M. KÀhönen (3495260)
- M. Laakso (7609358)
- M. MĂŒller-Nurasyid (7626752)
- M. O. Goodarzi (7626941)
- M. Perola (7605860)
- M. R. Barnes (7626581)
- M. R. Jarvelin (7611464)
- M. Uusitupa (7626860)
- M. X. Sosa (7626833)
- N. Amin (7611452)
- N. Bouatia-Naji (7609265)
- N. Eriksson (7626866)
- N. Franceschini (7625954)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. Klopp (7611599)
- N. L. Pedersen (7609403)
- N. Narisu (7609415)
- N. Poulter (7611311)
- N. R. Lee (7626734)
- N. W. Rayner (7626794)
- O. H. Franco (7625993)
- O. L. Holmen (7626680)
- O. Meirelles (7626716)
- O. Melander (7602683)
- P. B. Munroe (7602386)
- P. Bovet (7626764)
- P. Deloukas (7603691)
- P. E. Schwarz (7603253)
- P. Elliott (1293702)
- P. Eriksson (7626635)
- P. F. O'Reilly (7626560)
- P. Froguel (7609517)
- P. Howard (7611350)
- P. K. Magnusson (7609379)
- P. Komulainen (4753311)
- P. M. Ridker (7605368)
- P. Meneton (7626773)
- P. P. Pramstaller (7626770)
- P. S. Chines (7626599)
- P. Sever (7602536)
- P. Vollenweider (4002164)
- P. W. Franks (7605191)
- R. A. Jensen (7626695)
- R. Elosua (7605998)
- R. H. Chung (7626605)
- R. J. Loos (7608845)
- R. J. Strawbridge (7626656)
- R. Jansen (27731)
- R. Joehanes (7626959)
- R. M. Fraser (7626821)
- R. M. Krauss (7626722)
- R. Nagaraja (7612157)
- R. Rauramaa (7626923)
- R. Rettig (7611203)
- R. Roberts (2820928)
- R. S. Cooper (7626785)
- R. S. Vasan (7626878)
- R. Wilks (7626563)
- S. Bandinelli (7611518)
- S. Bevan (7626584)
- S. C. Hunt (7626686)
- S. Edkins (7626626)
- S. Enroth (7626632)
- S. Hercberg (4444465)
- S. K. Ganesh (7626842)
- S. K. Kim (2173768)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. Lobbens (7626746)
- S. MÀnnistö (7626749)
- S. R. Bornstein (7609526)
- S. Sanna (7609256)
- S. Sebert (7626812)
- S. Shah (4421101)
- T. A. Lakka (7626731)
- T. Axelsson (7626575)
- T. D. Spector (7608968)
- T. Esko (7626638)
- T. Fall (7625915)
- T. Ferreira (3480845)
- T. Forrester (7626653)
- T. H. Pers (7626953)
- T. Illig (7609322)
- T. Johnson (7602368)
- T. L. Assimes (7605317)
- T. LehtimÀki (3495257)
- T. P. Yang (7626617)
- T. Quertermous (7626788)
- T. Tanaka (3979952)
- T. Wilsgaard (3474971)
- T. Y. Wong (7626602)
- U. de Faire (7605206)
- U. Gyllensten (7612145)
- U. Thorsteinsdottir (7606031)
- V. Gudnason (7605347)
- V. Mijatovic (7626779)
- V. Pihur (7626914)
- V. Salomaa (7605350)
- V. Vitart (7609463)
- W. H. Sheu (7626815)
- W. J. Lee (1486369)
- W. MĂ€rz (7609394)
- W. Palmas (7626932)
- W. Zhang (820655)
- W. Zhao (696097)
- Wellcome Trust Case Control Consortium (7590752)
- X. Guo (1820437)
- X. Li (536560)
- X. Sim (7626824)
- X. Zhu (1590766)
- Y. A. Shin (7626818)
- Y. D. Chen (5184422)
- Y. J. Kim (1781752)
- Y. K. Kim (7626704)
- Y. Wu (1590877)
- Z. Kutalik (7626725)
- Publication venue
- Publication date
- 12/09/2016
- Field of study
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation
Rare and low-frequency coding variants alter human adult heigh
- Author
- A. A. Burt (7725410)
- A. D. Morris (7611470)
- A. E. Justice (7652732)
- A. E. Locke (7698281)
- A. G. Uitterlinden (7611476)
- A. Giri (7725485)
- A. I. den Hollander (7725449)
- A. J. Cox (7725431)
- A. K. Manning (7652627)
- A. L. Mazul (7725590)
- A. Linneberg (3444095)
- A. Lophatananon (4901776)
- A. M. Dunning (7658231)
- A. Mahajan (7603748)
- A. Metspalu (7626776)
- A. Morgan (7688165)
- A. P. Morris (7611419)
- A. P. Patel (7725620)
- A. P. Reiner (7626014)
- A. Pattie (7725623)
- A. Pirie (7725632)
- A. R. Van Der Leij (7725680)
- A. R. Wood (7685348)
- A. Rasheed (7605908)
- A. Robino (7725638)
- A. S. Butterworth (7605158)
- A. T. Hattersley (7609073)
- A. Teumer (7609454)
- A. Tybjaerg-Hansen (7605182)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- A. V. Smith (7605131)
- A. Varbo (7725686)
- A. W. Hewitt (7725509)
- A. Y. Chu (7725419)
- A.-E. Farmaki (7632758)
- B. Balkau (7609544)
- B. Banas (7725389)
- B. G. Nordestgaard (7605362)
- B. H. Thuesen (7725668)
- B. Kahali (7725533)
- C. A. Böger (7725401)
- C. A. Wang (7725698)
- C. B. Hoyng (2802346)
- C. Christensen (7652747)
- C. D. Langefeld (7646192)
- C. E. Lewis (7725572)
- C. E. Pennell (7653287)
- C. Hayward (7609304)
- C. J. Packard (7652738)
- C. J. Willer (7611383)
- C. Kooperberg (7689857)
- C. Langenberg (7608872)
- C. M. Lindgren (7611374)
- C. M. van Duijn (7626872)
- C. Medina-Gomez (7653182)
- C. N. A. Palmer (7660355)
- C. Oxvig (7725728)
- C. Schurmann (7725359)
- CHD Exome+ Consortium (7715321)
- Christopher P. Nelson (7625975)
- D. A. Mackey (7725584)
- D. Arveiler (7652327)
- D. F. Easton (7608179)
- D. F. Reilly (7652717)
- D. I. Chasman (7605179)
- D. J. Carey (7725413)
- D. J. Liu (7725725)
- D. J. Thompson (7603073)
- D. Lamparter (7725365)
- D. O. Mook-Kanamori (7725599)
- D. Posthuma (5044979)
- D. R. V. Edwards (7725689)
- D. R. Witte (7725707)
- D. S. Alam (7646294)
- D. Saleheen (7605173)
- D. Vozzi (7725695)
- D. W. Bowden (7725404)
- E. Albrecht (7612112)
- E. B. Larson (7725566)
- E. Boerwinkle (7609103)
- E. Di Angelantonio (7611773)
- E. Evangelou (7626641)
- E. Ferrannini (7725470)
- E. Ingelsson (7605335)
- E. K. Speliotes (7611380)
- E. M. Lange (7725563)
- E. Marouli (7626761)
- E. P. Bottinger (7689854)
- E. Tsafantakis (7636823)
- E. V. Appel (7725386)
- E. W. Demerath (7725446)
- E. Zeggini (7632767)
- EPIC-InterAct Consortium (7725719)
- ExomeBP Consortium (7715327)
- F. Drenos (7602632)
- F. Karpe (7611410)
- F. Kee (3531716)
- F. Renström (7611431)
- F. Rivadeneira (7611509)
- F. S. Collins (7609505)
- F. W. Asselbergs (3801271)
- F. Wang (1690585)
- G. Abecasis (7609514)
- G. B. Jensen (7725524)
- G. Breen (7632803)
- G. Cuellar-Partida (7725434)
- G. Davies (7643840)
- G. Dedoussis (7626908)
- G. Girotto (7725488)
- G. J. de Borst (7698176)
- G. K. Hovingh (3801262)
- G. Lettre (7685792)
- G. M. Peloso (7605836)
- G. Marenne (7632953)
- G. P. Jarvik (7689860)
- G. Pasterkamp (7626023)
- G. Thorleifsson (7606022)
- G. Tromp (7646132)
- Global Lipids Genetics Consortium (7725722)
- GoT2D Genes Consortium (7715333)
- H. Boeing (6548024)
- H. Kitajima (7725548)
- H. Kuivaniemi (7646135)
- H. Li (1597072)
- H. Lin (3462437)
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- H. Oksa (7652756)
- H. R. Warren (7725701)
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- H. Yaghootkar (7652636)
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- I. B. Borecki (7685702)
- I. Brandslund (6446831)
- I. Ford (5772110)
- I. Gandin (7725479)
- I. J. Deary (7620122)
- I. M. Heid (7611266)
- I. Ntalla (7725608)
- I. Rudan (7609409)
- I.-T. Lee (7725569)
- J. A. Perry (7725626)
- J. A. Smith (1888894)
- J. Bork-Jensen (7652663)
- J. C. Chambers (7605185)
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- J. C. Galbany (7725428)
- J. Corley (7725425)
- J. D. Faul (7725467)
- J. D. Rioux (7725635)
- J. Danesh (7605383)
- J. Ferrieres (7725473)
- J. G. Dennis (7725452)
- J. G. Wilson (7609118)
- J. H. Zhao (1395031)
- J. Hernesniemi (7725506)
- J. I. Rotter (7626935)
- J. Kaprio (7647446)
- J. Kontto (7652669)
- J. Kriebel (7725554)
- J. Kuusisto (7609355)
- J. Li (51350)
- J. Lindström (3847444)
- J. Luan (7609367)
- J. M. M. Howson (7646075)
- J. M. Starr (7620119)
- J. Marten (7652654)
- J. N. Hirschhorn (7609139)
- J. P . Cook (7725422)
- J. P. Tyrer (7725671)
- J. R. B. Perry (7632749)
- J. R. O'Connel (7725611)
- J. S. Kooner (7605356)
- J. Tuomilehto (7611044)
- J. van Setten (7625924)
- J. W. Jukema (7625996)
- J. Wessel (7725704)
- J. Yao (1794466)
- J.-C. Tardif (7725665)
- J.-H. Jansson (7725521)
- K. B. Kluivers (7725551)
- K. D. Taylor (7626905)
- K. E. North (7635935)
- K. E. Stirrups (7626839)
- K. E. Tansey (7725662)
- K. H. Allin (7605359)
- K. HeikkilÀ (7652294)
- K. Hveem (7626929)
- K. K. Aben (7725383)
- K. L. Mohlke (7605866)
- K. L. Young (7725371)
- K. M. Harris (7725500)
- K. Meidtner (7725593)
- K. Nikus (7626950)
- K. R. Owen (7685480)
- K. S. Lo (7725350)
- K. S. Ruth (7725641)
- K. S. Small (7652315)
- K. Sandow (7725644)
- K. Stefansson (7606001)
- L. A. Kiemeney (7619285)
- L. A. Lange (7646105)
- L. Broer (7645085)
- L. E. Bang (7725392)
- L. F. Bielak (7725398)
- L. He (1942591)
- L. J. Hocking (7725512)
- L. L. Bonnycastle (7609496)
- L. Lind (7625984)
- L. M. 't Hart (7725659)
- L. M. O. Loohuis (7725614)
- L. M. Yerges-Armstrong (7725716)
- L. S. Adair (7626569)
- L. Southam (7632728)
- L.-A. Lin (7725578)
- L.-P. LyytikÀinen (7725581)
- M. A. Ikram (7626689)
- M. A. Jhun (7725527)
- M. A. Nalls (7646225)
- M. A. Rivas (7725380)
- M. Allison (6553730)
- M. B. Schulze (7725653)
- M. Benn (7725395)
- M. BlĂŒher (4908460)
- M. Boehnke (7605344)
- M. C. H. de Groot (7725440)
- M. C. Y. Ng (7725374)
- M. Cocca (7632734)
- M. Du (7725455)
- M. E. JĂžrgensen (7725530)
- M. F. Feitosa (7685738)
- M. Fornage (7609064)
- M. Gorski (7626956)
- M. Graff (7725347)
- M. H. Brilliant (7725407)
- M. Hollensted (7725515)
- M. I. McCarthy (7609121)
- M. J. Caulfield (7602383)
- M. K. Schmidt (7658327)
- M. Karaleftheri (7636826)
- M. KÀhönen (3495260)
- M. L. Bots (7686470)
- M. L. Grove (7725497)
- M. La Bianca (7725560)
- M. Laakso (7609358)
- M. M. Ferrario (7652330)
- M. MĂŒller-Nurasyid (7626752)
- M. Nauck (6643733)
- M. Neville (7725602)
- M. O. Woods (7725710)
- M. P. Segura-Lepe (7725656)
- M. Perola (7605860)
- M. Stumvoll (7609448)
- M. Walker (1291794)
- MAGIC Investigators (7698314)
- N. G. Martin (7639949)
- N. Grarup (7627439)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. L. Heard-Costa (7698326)
- N. M. van Schoor (7725683)
- N. Robertson (61307)
- N. Sattar (7608890)
- Nicholas G. D. Masca (7672691)
- O. L. Holmen (7626680)
- O. Pedersen (7627493)
- O. Polasek (7609424)
- O. Rolandsson (7652735)
- O. T. Raitakari (7647452)
- P. A. F. Madden (7725587)
- P. Amouyel (7605287)
- P. B. Munroe (7602386)
- P. Deloukas (7603691)
- P. Elliott (1293702)
- P. Gasparini (7725482)
- P. Gordon-Larsen (7725494)
- P. I. W. de Bakker (7605305)
- P. J. Schreiner (7725650)
- P. Jousilahti (7611407)
- P. Komulainen (4753311)
- P. Kovacs (7609346)
- P. L. Auer (7689797)
- P. L. Huang (7725518)
- P. L. Peissig (7646156)
- P. M. Ridker (7605368)
- P. Mitchell (7725596)
- P. Mudgal (7725377)
- P. R. Kamstrup (7725539)
- P. R. NjĂžlstad (7725605)
- P. Surendran (7652621)
- P. T. Ellinor (7725464)
- P. W. Franks (7605191)
- P. Yao (7725713)
- R. A. Ophoff (7725617)
- R. A. Scott (2840021)
- R. Chowdhury (7646300)
- R. de Mutsert (7725443)
- R. Frikke-Schmidt (7605842)
- R. J. F. Loos (7725731)
- R. Keeman (7725545)
- R. Li-Gao (7725575)
- R. Rauramaa (7626923)
- R. S. Fine (7725356)
- R. S. Kahn (7725536)
- R. Uher (7725674)
- R. Varma (7695929)
- R. Young (7646078)
- ReproGen Consortium (7715342)
- S. A. Lubitz (7646210)
- S. Bergmann (7612121)
- S. D. Gordon (7725491)
- S. de Denus (7725437)
- S. F. Nielsen (7646099)
- S. Feng (2571244)
- S. Gustafsson (7698278)
- S. H. Vermeulen (7725692)
- S. Johansson (4737543)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. KĂŒry (7725557)
- S. L. R. Kardia (7725542)
- S. M. Willems (7647404)
- S. MÀnnistö (7626749)
- S. Padmanabhan (637530)
- S. RĂŒeger (7725362)
- S. Shah (4421101)
- S. Sivapalaratnam (7604441)
- S. Trompet (7625936)
- S. Ulivi (7725677)
- S. Vedantam (7698287)
- S. W. van der Laan (7625912)
- S. Wang (673797)
- T. A. Lakka (7626731)
- T. B. Harris (7605353)
- T. D. Spector (7608968)
- T. E. Galesloot (7625930)
- T. Ebeling (7725458)
- T. Esko (7626638)
- T. F. Vogt (7652723)
- T. H. Pers (7626953)
- T. Hansen (3919604)
- T. JĂžrgensen (7627442)
- T. Karaderi (6553712)
- T. Kocher (5864939)
- T. L. Edwards (7725461)
- T. LehtimÀki (3495257)
- T. M. Frayling (7608959)
- T. N. Person (7725629)
- T. R. Kjaer (7725353)
- T. V. Varga (7652696)
- T. W. Winkler (7647401)
- T2D-Genes Consortium (7715348)
- U. Thorsteinsdottir (7606031)
- V. Giedraitis (7625945)
- V. Gudnason (7605347)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Turcot (7725368)
- V. Vitart (7609463)
- W. Gan (7725476)
- W. Zhang (820655)
- W. Zhao (696097)
- W. Zhou (1551811)
- X. Guo (1820437)
- X. Jiang (1784158)
- X. Lin (3771379)
- X. Sim (7626824)
- X. Zhan (1504810)
- Y. Jia (2014003)
- Y. Liu (543492)
- Y. Lu (1469287)
- Y. Sapkota (7725647)
- Y. Wang (473169)
- Y. Wu (1590877)
- Y.-D. I. Chen (7725416)
- Z. Kutalik (7626725)
- Ă. Helgeland (7725503)
- Publication venue
- Publication date
- 01/02/2017
- Field of study
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2âcentimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2âcentimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways