Photodynamic therapy as adjuvant therapy in surgically treated pleural malignancies.

Five patients with a pleural malignancy (four malignant mesotheliomas and one localized low grade carcinoid) were treated with maximal surgical resection of the tumour followed by intraoperative adjuvant photodynamic therapy (PDT). The additional photodynamic treatment was performed with light of 652 nm from a high power diode laser, and meta-tetrahydroxy phenylchlorin as the photosensitizer. The light delivery to the thoracic cavity was monitored by in situ isotropic light detectors. The position of the light delivery fibre was adjusted to achieve optimal light distribution, taking account of reflected and scattered light in this hollow cavity. There was no 30-day post-operative mortality and only one patient suffered from a major complication (diaphragmatic rupture and haematopericardium). The operation time was increased by a maximum of 1 h to illuminate the total hemithoracic surface with 10 J cm(-2) (incident and scattered light). The effect of the adjuvant PDT was monitored by examination of biopsies taken 24 h after surgery under thoracoscopic guidance. Significant damage, including necrosis, was observed in the marker lesions with remaining malignancy compared with normal tissue samples, which showed only an infiltration with PMN cells and oedema of the striated muscles cells. Of the five patients treated, four are alive with no signs of recurrent tumour with a follow-up of 9-11 months. One patient was diagnosed as having a tumour dissemination in the skin around the thoracoscopy scar and died of abdominal tumour spread. Light delivery to large surfaces for adjuvant PDT is feasible in a relatively short period of time (< 1 h). In situ dosimetry ensures optimal light distribution and allows total doses (incident plus scattered light) to be monitored at different positions within the cavity. This combination of light delivery and dosimetry is well suited for adjuvant treatment with PDT in malignant pleural tumours

Preliminary evaluation of coffee crops under different doses of nitrogen with a spad meter and leaf nitrogen.

Abstract: The objective of this study was to establish correlations among the total N and the SPAD read- ings in Coffea arabica leaves. This study is part of a project that aims to evaluate the agronomic and environmental efficiency of nitrate-based fertilizers compared to conventional nitrogen fertilizers used in the cultivation of coffee

Au-ZSM-5 catalyses the selective oxidation of CH4 to CH3OH and CH3COOH using O2

The oxidation of methane, the main component of natural gas, to selectively form oxygenated chemical feedstocks using molecular oxygen has been a long-standing grand challenge in catalysis. Here, using gold nanoparticles supported on the zeolite ZSM-5, we introduce a method to oxidize methane to methanol and acetic acid in water at temperatures between 120 and 240 °C using molecular oxygen in the absence of any added coreductant. Electron microscopy reveals that the catalyst does not contain gold atoms or clusters, but rather gold nanoparticles are the active component, while a mechanism involving surface adsorbed species is proposed in which methanol and acetic acid are formed via parallel pathways. [Figure not available: see fulltext.]

Walking the neighbourhood, seeing the small details of community life: reflections from a photography walking tour

This paper examines the value of photography walking tours for exploring meanings and experiences of community. The work is part of a larger visual research project which sought to examine the everyday lives of residents in a neighbourhood identified as ‘disadvantaged’, with the tour being organized as an opportunity for residents to identify what they valued about their local environment and what they considered to be problematic. The dynamics involved in gathering this photographic record are one element of the discussion as is analysis of the ways in which the participants constructed and re-constructed their sense of community through the different examples they selected for photographing. The paper is thus concerned with the ways in which visual data bring different insights to understandings of which practices, services and resources are embedded in meanings of community in working-class neighbourhoods and, in turn, how such data might have value for informing policy and practice about the experiences of inequality in contemporary England

Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer

The goal of this work was to examine toxicity and risk factors after irradiation of the cervical spinal cord. A total of 437 patients irradiated for a laryngeal and oropharyngeal carcinoma were eligible (median follow-up 27 months). Spinal cord contouring was defined differently over time as anatomically defined spinal cord area (SCA) and the spinal cord on CT (SC) with a margin of 3 or 5 mm (SCP3/SCP5). None developed chronic progressive radiation myelopathy (CPRM) (maximum spinal dose 21.8-69 Gy); 3.9% (17/437) developed a Lhermitte sign (LS) with a median duration of 6 months (range 1-30 months) and was reversible in all patients. Risk factors for developing LS were younger age (52 vs. 61 years, p <0.001), accelerated RT (12/17 patients, p <0.005), and dose-volume relationships for SCA with a parts per thousand yenaEuro parts per thousand 45 Gy of 14.15 cm(3) and 7.9 cm(3) for patients with and without LS, respectively. LS is more frequently observed in younger patients and in patients treated with accelerated radiotherapy. A dose-volume relationship was seen for V45 in the case of SCA. For higher doses, no clear dose-volume relationships were observed