Guadalupe pluton–Mariposa Formation age relationships in the southern Sierran Foothills: Onset of Mesozoic subduction in northern California?

We report a new 153 ± 2 Ma SIMS U-Pb date for zircons from the hypabyssal Guadalupe pluton which crosscuts and contact metamorphoses upper crustal Mariposa slates in the southern Sierra. A ~950 m thick section of dark metashales lies below sandstones from which clastic zircons were analyzed at 152 ± 2 Ma. Assuming a compacted depositional rate of ~120 m/Myr, accumulation of Mariposa volcanogenic sediments, which overlie previously stranded Middle Jurassic and older ophiolite + chert-argillite belts in the Sierran Foothills, began no later than ~160 Ma. Correlative Oxfordian-Kimmeridgian strata of the Galice Formation occupy a similar position in the Klamath Mountains. We speculate that the Late Jurassic was a time of transition from (1) a mid-Paleozoic–Middle Jurassic interval of mainly but not exclusively strike-slip and episodic docking of oceanic terranes; (2) to transpressive plate underflow, producing calcalkaline igneous arc rocks ± outboard blueschists at ~170–150 Ma, whose erosion promoted accumulation of the Mariposa-Galice overlap strata; (3) continued transpressive underflow attending ~200 km left-lateral displacement of the Klamath salient relative to the Sierran arc at ~150–140 Ma and development of the apparent polar wander path cusps for North and South America; and (4) then nearly orthogonal mid and Late Cretaceous convergence commencing at ~125–120 Ma, during reversal in tangential motion of the Pacific plate. After ~120 Ma, nearly head-on subduction involving minor dextral transpression gave rise to voluminous continent-building juvenile and recycled magmas of the Sierran arc, providing the erosional debris to the Great Valley fore arc and Franciscan trench

His story/her story: A dialogue about including men and masculinities in the women’s studies curriculum

The article discusses the issue of inclusion of men and masculinities in the Women\u27s Studies curriculum. Women\u27s Studies programs were started to compensate for the male domination in the academics. Women\u27s Studies presented a platform where scholarship for women was produced and taken seriously, female students and faculty could find their say or voice, and theoretical investigations required for the advancement of the aims of the women\u27s movement could take place. If the academy as a whole does not sufficiently integrate Women\u27s Studies into the curriculum, integrating Men\u27s Studies into Women\u27s Studies might end up further marginalizing Women\u27s Studies by decreasing the number of classroom hours students spend engaging women\u27s lives and feminist scholarship. Such an integration would presents an another form of male privilege, with men manipulating their way into the only branch of scholarship that has consistently focused on women. On a ground level, feminist scholars are apprehensive that a move from a Women\u27s Studies program to a Gender Studies program will reduce the political aspect of women\u27s programs

A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset.

OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset. METHODS: Twenty-five previously untreated consecutive patients with recent-onset (\u3c 24 mo) diffuse progressive cutaneous SSc received MMF as the only disease-modifying therapy. Modified Rodnan skin score (mRSS) and affected body surface area (BSA) were compared from initiation of MMF to study end. Pulmonary function tests performed at the same institution before therapy and at study end were available in 15 patients. Histopathology and real-time PCR assessment of fibrosis-related gene expression were performed before and after treatment in skin biopsies from 3 patients. RESULTS: At 18.2 ± 8.73 months of MMF therapy (median 2000 mg/day) the mRSS decreased from 24.56 ± 8.62 to 14.52 ± 10.9 (p = 0.0004) and the affected BSA from 36% ± 16% to 14% ± 13.3% (p = 0.00001). Pulmonary function tests remained stable from initiation of MMF to the end of the study. Skin histopathology showed a remarkable reduction in accumulation of fibrotic tissue. Real-time PCR of skin biopsies demonstrated a marked decrease in expression of fibrosis-related genes. CONCLUSION: Patients with diffuse progressive cutaneous SSc of recent onset treated with MMF experienced marked improvement in skin involvement and stabilization of pulmonary function. Skin biopsies from 3 patients demonstrated histopathological improvement and decreased expression of fibrosis-related genes

Multiplexed DNA-Modified Electrodes

We report the use of silicon chips with 16 DNA-modified electrodes (DME chips) utilizing DNA-mediated charge transport for multiplexed detection of DNA and DNA-binding protein targets. Four DNA sequences were simultaneously distinguished on a single DME chip with 4-fold redundancy, including one incorporating a single base mismatch. These chips also enabled investigation of the sequence-specific activity of the restriction enzyme Alu1. DME chips supported dense DNA monolayer formation with high reproducibility, as confirmed by statistical comparison to commercially available rod electrodes. The working electrode areas on the chips were reduced to 10 μm in diameter, revealing microelectrode behavior that is beneficial for high sensitivity and rapid kinetic analysis. These results illustrate how DME chips facilitate sensitive and selective detection of DNA and DNA-binding protein targets in a robust and internally standardized multiplexed format

Biases in Expansion Distances of Novae Arising from the Prolate Geometry of Nova Shells

(abridged) Expansion distances (or expansion parallaxes) for classical novae are based on comparing a measurement of the shell expansion velocity, multiplied by the time since outburst, with some measure of the angular size of the shell. We review and formalize this method in the case of prolate spheroidal shells. We present expressions for the maximum line-of-sight velocity from a complete, expanding shell and for its projected major and minor axes, in terms of the intrinsic axis ratio and the inclination of the polar axis to the line of sight. For six distinct definitions of ``angular size'', we tabulate the error in distance that is introduced under the assumption of spherical symmetry (i.e., without correcting for inclination and axis ratio). The errors can be significant and systematic, affecting studies of novae whether considered individually or statistically. Each of the six estimators overpredicts the distance when the polar axis is close to the line of sight, and most underpredict the distance when the polar axis is close to the plane of the sky. The straight mean of the projected semimajor and semiminor axes gives the least distance bias for an ensemble of randomly oriented prolate shells. The best individual expansion distances, however, result from a full spatio-kinematic modeling of the nova shell. We discuss several practical complications that affect expansion distance measurements of real nova shells. Nova shell expansion distances be based on velocity and angular size measurements made contemporaneously if possible, and the same ions and transitions should be used for the imaging and velocity measurements. We emphasize the need for complete and explicit reporting of measurement procedures and results, regardless of the specific method used.Comment: 21 pages, LaTeX, uses aasms4.sty, to be published in Publ. Astron. Soc. of the Pacific, May 200

Theoretical studies of a hydrogen abstraction tool for nanotechnology

In the design of a nanoscale, site-specific hydrogen abstraction tool, the authors suggest the use of an alkynyl radical tip. Using ab initio quantum-chemistry techniques including electron correlation they model the abstraction of hydrogen from dihydrogen, methane, acetylene, benzene and isobutane by the acetylene radical. By conservative estimates, the abstraction barrier is small (less than 7.7 kcal mol^-1) in all cases except for acetylene and zero in the case of isobutane. Thermal vibrations at room temperature should be sufficient to supply the small activation energy. Several methods of creating the radical in a controlled vacuum setting should be feasible. The authors show how nanofabrication processes can be accurately and inexpensively designed in a computational framework

Analytic Approximations for Transit Light Curve Observables, Uncertainties, and Covariances

The light curve of an exoplanetary transit can be used to estimate the planetary radius and other parameters of interest. Because accurate parameter estimation is a non-analytic and computationally intensive problem, it is often useful to have analytic approximations for the parameters as well as their uncertainties and covariances. Here we give such formulas, for the case of an exoplanet transiting a star with a uniform brightness distribution. We also assess the advantages of some relatively uncorrelated parameter sets for fitting actual data. When limb darkening is significant, our parameter sets are still useful, although our analytic formulas underpredict the covariances and uncertainties.Comment: 33 pages, 14 figure